Talaromyces marneffei and nontuberculous mycobacteria co-infection in HIV-negative patients

Abstract To describe the clinical features and the risk factors for nontuberculous mycobacteria (NTM) and Talaromyces marneffei (TM) co-infections in HIV-negative patients. A multicenter retrospective study in 13 hospitals, and a systematic literature review were performed of original articles publi...

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Autores principales:	Ye Qiu, Jie Huang, Yu Li, Wen Zeng, Mianluan Pan, Jiemei Cen, Hui Zhang, Xuejiao Sun, Dongming Qu, Jianquan Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/97aa14b16b70423bbcd168ed54988fb3
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spelling	oai:doaj.org-article:97aa14b16b70423bbcd168ed54988fb32021-12-02T18:50:44ZTalaromyces marneffei and nontuberculous mycobacteria co-infection in HIV-negative patients10.1038/s41598-021-95686-02045-2322https://doaj.org/article/97aa14b16b70423bbcd168ed54988fb32021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95686-0https://doaj.org/toc/2045-2322Abstract To describe the clinical features and the risk factors for nontuberculous mycobacteria (NTM) and Talaromyces marneffei (TM) co-infections in HIV-negative patients. A multicenter retrospective study in 13 hospitals, and a systematic literature review were performed of original articles published in English related to TM/NTM co-infections. HIV-negative patients with TM and NTM co-infections comprised Group 1; TM-only infection Group 2; NTM-only infection Group 3; and healthy volunteers Group 4. Univariate logistic analysis was used to estimate the potential risk factors of TM/NTM co-infections. A total of 22 cases of TM and NTM co-infections were enrolled. Of these, 17 patients (77.3%) had a missed diagnosis of one of the TM or NTM pathogens. The anti-IFN-γ autoantibodies (AIGAs) titer, white blood cell (WBC), neutrophil counts (N), erythrocyte sedimentation rate (ESR), C reactive protein (CRP), globulin, and immunoglobulin G (IgG) levels of Group 1 were higher than those of the other groups, whereas the levels of CD4+T cells was lower than those of other groups. There was a significant negative correlation between the AIGA titers and the number of CD4+T cells (P < 0.05). Factors including the ratio of the actual values to the cut-off values of AIGAs, WBC, N, HGB, CD4+T cells, IgG, IgM, IgA, serum globulin, ESR, and CRP were taken as potential risk factors for TM and NTM co-infection. Most patients with TM and NTM co-infection had a missed diagnosis of one of the TM or NTM pathogens. The levels of AIGAs, WBC, N, ESR, and CRP in TM and NTM co-infections were remarkably higher than in mono-infection. High-titer AIGAs may be a potential risk factor and susceptibility factor for co-infection of TM and NTM in HIV-negative hosts.Ye QiuJie HuangYu LiWen ZengMianluan PanJiemei CenHui ZhangXuejiao SunDongming QuJianquan ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ye Qiu Jie Huang Yu Li Wen Zeng Mianluan Pan Jiemei Cen Hui Zhang Xuejiao Sun Dongming Qu Jianquan Zhang Talaromyces marneffei and nontuberculous mycobacteria co-infection in HIV-negative patients
description	Abstract To describe the clinical features and the risk factors for nontuberculous mycobacteria (NTM) and Talaromyces marneffei (TM) co-infections in HIV-negative patients. A multicenter retrospective study in 13 hospitals, and a systematic literature review were performed of original articles published in English related to TM/NTM co-infections. HIV-negative patients with TM and NTM co-infections comprised Group 1; TM-only infection Group 2; NTM-only infection Group 3; and healthy volunteers Group 4. Univariate logistic analysis was used to estimate the potential risk factors of TM/NTM co-infections. A total of 22 cases of TM and NTM co-infections were enrolled. Of these, 17 patients (77.3%) had a missed diagnosis of one of the TM or NTM pathogens. The anti-IFN-γ autoantibodies (AIGAs) titer, white blood cell (WBC), neutrophil counts (N), erythrocyte sedimentation rate (ESR), C reactive protein (CRP), globulin, and immunoglobulin G (IgG) levels of Group 1 were higher than those of the other groups, whereas the levels of CD4+T cells was lower than those of other groups. There was a significant negative correlation between the AIGA titers and the number of CD4+T cells (P < 0.05). Factors including the ratio of the actual values to the cut-off values of AIGAs, WBC, N, HGB, CD4+T cells, IgG, IgM, IgA, serum globulin, ESR, and CRP were taken as potential risk factors for TM and NTM co-infection. Most patients with TM and NTM co-infection had a missed diagnosis of one of the TM or NTM pathogens. The levels of AIGAs, WBC, N, ESR, and CRP in TM and NTM co-infections were remarkably higher than in mono-infection. High-titer AIGAs may be a potential risk factor and susceptibility factor for co-infection of TM and NTM in HIV-negative hosts.
format	article
author	Ye Qiu Jie Huang Yu Li Wen Zeng Mianluan Pan Jiemei Cen Hui Zhang Xuejiao Sun Dongming Qu Jianquan Zhang
author_facet	Ye Qiu Jie Huang Yu Li Wen Zeng Mianluan Pan Jiemei Cen Hui Zhang Xuejiao Sun Dongming Qu Jianquan Zhang
author_sort	Ye Qiu
title	Talaromyces marneffei and nontuberculous mycobacteria co-infection in HIV-negative patients
title_short	Talaromyces marneffei and nontuberculous mycobacteria co-infection in HIV-negative patients
title_full	Talaromyces marneffei and nontuberculous mycobacteria co-infection in HIV-negative patients
title_fullStr	Talaromyces marneffei and nontuberculous mycobacteria co-infection in HIV-negative patients
title_full_unstemmed	Talaromyces marneffei and nontuberculous mycobacteria co-infection in HIV-negative patients
title_sort	talaromyces marneffei and nontuberculous mycobacteria co-infection in hiv-negative patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/97aa14b16b70423bbcd168ed54988fb3
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Talaromyces marneffei and nontuberculous mycobacteria co-infection in HIV-negative patients

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