Red blood cell blood group A antigen level affects the ability of heparin and PfEMP1 antibodies to disrupt Plasmodium falciparum rosettes

Abstract Background The histo-blood group ABO system has been associated with adverse outcomes in COVID-19, thromboembolic diseases and Plasmodium falciparum malaria. An integral part of the severe malaria pathogenesis is rosetting, the adherence of parasite infected red blood cells (RBCs) to uninfe...

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Autores principales: Pontus Hedberg, Madle Sirel, Kirsten Moll, Mpungu Steven Kiwuwa, Petter Höglund, Ulf Ribacke, Mats Wahlgren
Formato: article
Lenguaje:EN
Publicado: BMC 2021
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Acceso en línea:https://doaj.org/article/97aa16a7bd47439d99c9d4aa4b2545ab
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