The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells

PIX proteins activate the small GTPases Rac and Cdc42, and are known to have numerous functions in a variety of cell types. Using a genetic screen in C. elegans, the authors find that PIX-1 is required for the assembly or stability of integrin adhesion complexes between muscle cells.

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Detalles Bibliográficos
Autores principales: Jasmine C. Moody, Hiroshi Qadota, April R. Reedy, C. Denise Okafor, Niveda Shanmugan, Yohei Matsunaga, Courtney J. Christian, Eric A. Ortlund, Guy M. Benian
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/97b17489d39b4b8787aa01fe4c4441f9
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Sumario:PIX proteins activate the small GTPases Rac and Cdc42, and are known to have numerous functions in a variety of cell types. Using a genetic screen in C. elegans, the authors find that PIX-1 is required for the assembly or stability of integrin adhesion complexes between muscle cells.