The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells

PIX proteins activate the small GTPases Rac and Cdc42, and are known to have numerous functions in a variety of cell types. Using a genetic screen in C. elegans, the authors find that PIX-1 is required for the assembly or stability of integrin adhesion complexes between muscle cells.

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Autores principales:	Jasmine C. Moody, Hiroshi Qadota, April R. Reedy, C. Denise Okafor, Niveda Shanmugan, Yohei Matsunaga, Courtney J. Christian, Eric A. Ortlund, Guy M. Benian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/97b17489d39b4b8787aa01fe4c4441f9
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spelling	oai:doaj.org-article:97b17489d39b4b8787aa01fe4c4441f92021-12-02T18:01:53ZThe Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells10.1038/s41467-020-18852-42041-1723https://doaj.org/article/97b17489d39b4b8787aa01fe4c4441f92020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18852-4https://doaj.org/toc/2041-1723PIX proteins activate the small GTPases Rac and Cdc42, and are known to have numerous functions in a variety of cell types. Using a genetic screen in C. elegans, the authors find that PIX-1 is required for the assembly or stability of integrin adhesion complexes between muscle cells.Jasmine C. MoodyHiroshi QadotaApril R. ReedyC. Denise OkaforNiveda ShanmuganYohei MatsunagaCourtney J. ChristianEric A. OrtlundGuy M. BenianNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jasmine C. Moody Hiroshi Qadota April R. Reedy C. Denise Okafor Niveda Shanmugan Yohei Matsunaga Courtney J. Christian Eric A. Ortlund Guy M. Benian The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells
description	PIX proteins activate the small GTPases Rac and Cdc42, and are known to have numerous functions in a variety of cell types. Using a genetic screen in C. elegans, the authors find that PIX-1 is required for the assembly or stability of integrin adhesion complexes between muscle cells.
format	article
author	Jasmine C. Moody Hiroshi Qadota April R. Reedy C. Denise Okafor Niveda Shanmugan Yohei Matsunaga Courtney J. Christian Eric A. Ortlund Guy M. Benian
author_facet	Jasmine C. Moody Hiroshi Qadota April R. Reedy C. Denise Okafor Niveda Shanmugan Yohei Matsunaga Courtney J. Christian Eric A. Ortlund Guy M. Benian
author_sort	Jasmine C. Moody
title	The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells
title_short	The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells
title_full	The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells
title_fullStr	The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells
title_full_unstemmed	The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells
title_sort	rho-gef pix-1 directs assembly or stability of lateral attachment structures between muscle cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/97b17489d39b4b8787aa01fe4c4441f9
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The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells

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