FMRI activity in the macaque cerebellum evoked by intracortical microstimulation of the primary somatosensory cortex: evidence for polysynaptic propagation.

Simultaneous electrical microstimulation (EM) and functional magnetic resonance imaging (fMRI) is a useful tool for probing connectivity across brain areas in vivo. However, it is not clear whether intracortical EM can evoke blood-oxygenation-level-dependent (BOLD) signal in areas connected polysyna...

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Autores principales:	Teppei Matsui, Kenji W Koyano, Keita Tamura, Takahiro Osada, Yusuke Adachi, Kentaro Miyamoto, Junichi Chikazoe, Tsukasa Kamigaki, Yasushi Miyashita
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/97b24777c8444213ac10090f3ba6d7c1
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spelling	oai:doaj.org-article:97b24777c8444213ac10090f3ba6d7c12021-11-18T08:10:33ZFMRI activity in the macaque cerebellum evoked by intracortical microstimulation of the primary somatosensory cortex: evidence for polysynaptic propagation.1932-620310.1371/journal.pone.0047515https://doaj.org/article/97b24777c8444213ac10090f3ba6d7c12012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23118875/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Simultaneous electrical microstimulation (EM) and functional magnetic resonance imaging (fMRI) is a useful tool for probing connectivity across brain areas in vivo. However, it is not clear whether intracortical EM can evoke blood-oxygenation-level-dependent (BOLD) signal in areas connected polysynaptically to the stimulated site. To test for the presence of the BOLD activity evoked by polysynaptic propagation of the EM signal, we conducted simultaneous fMRI and EM in the primary somatosensory cortex (S1) of macaque monkeys. We in fact observed BOLD activations in the contralateral cerebellum which is connected to the stimulation site (i.e. S1) only through polysynaptic pathways. Furthermore, the magnitude of cerebellar activations was dependent on the current amplitude of the EM, confirming the EM is the cause of the cerebellar activations. These results suggest the importance of considering polysynaptic signal propagation, particularly via pathways including subcortical structures, for correctly interpreting 'functional connectivity' as assessed by simultaneous EM and fMRI.Teppei MatsuiKenji W KoyanoKeita TamuraTakahiro OsadaYusuke AdachiKentaro MiyamotoJunichi ChikazoeTsukasa KamigakiYasushi MiyashitaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e47515 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Teppei Matsui Kenji W Koyano Keita Tamura Takahiro Osada Yusuke Adachi Kentaro Miyamoto Junichi Chikazoe Tsukasa Kamigaki Yasushi Miyashita FMRI activity in the macaque cerebellum evoked by intracortical microstimulation of the primary somatosensory cortex: evidence for polysynaptic propagation.
description	Simultaneous electrical microstimulation (EM) and functional magnetic resonance imaging (fMRI) is a useful tool for probing connectivity across brain areas in vivo. However, it is not clear whether intracortical EM can evoke blood-oxygenation-level-dependent (BOLD) signal in areas connected polysynaptically to the stimulated site. To test for the presence of the BOLD activity evoked by polysynaptic propagation of the EM signal, we conducted simultaneous fMRI and EM in the primary somatosensory cortex (S1) of macaque monkeys. We in fact observed BOLD activations in the contralateral cerebellum which is connected to the stimulation site (i.e. S1) only through polysynaptic pathways. Furthermore, the magnitude of cerebellar activations was dependent on the current amplitude of the EM, confirming the EM is the cause of the cerebellar activations. These results suggest the importance of considering polysynaptic signal propagation, particularly via pathways including subcortical structures, for correctly interpreting 'functional connectivity' as assessed by simultaneous EM and fMRI.
format	article
author	Teppei Matsui Kenji W Koyano Keita Tamura Takahiro Osada Yusuke Adachi Kentaro Miyamoto Junichi Chikazoe Tsukasa Kamigaki Yasushi Miyashita
author_facet	Teppei Matsui Kenji W Koyano Keita Tamura Takahiro Osada Yusuke Adachi Kentaro Miyamoto Junichi Chikazoe Tsukasa Kamigaki Yasushi Miyashita
author_sort	Teppei Matsui
title	FMRI activity in the macaque cerebellum evoked by intracortical microstimulation of the primary somatosensory cortex: evidence for polysynaptic propagation.
title_short	FMRI activity in the macaque cerebellum evoked by intracortical microstimulation of the primary somatosensory cortex: evidence for polysynaptic propagation.
title_full	FMRI activity in the macaque cerebellum evoked by intracortical microstimulation of the primary somatosensory cortex: evidence for polysynaptic propagation.
title_fullStr	FMRI activity in the macaque cerebellum evoked by intracortical microstimulation of the primary somatosensory cortex: evidence for polysynaptic propagation.
title_full_unstemmed	FMRI activity in the macaque cerebellum evoked by intracortical microstimulation of the primary somatosensory cortex: evidence for polysynaptic propagation.
title_sort	fmri activity in the macaque cerebellum evoked by intracortical microstimulation of the primary somatosensory cortex: evidence for polysynaptic propagation.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/97b24777c8444213ac10090f3ba6d7c1
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FMRI activity in the macaque cerebellum evoked by intracortical microstimulation of the primary somatosensory cortex: evidence for polysynaptic propagation.

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