CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity

CAR-T targeting CD19 have been successfully used in a variety of B-cell malignancies but patients may eventually relapse. Here, the authors show that CD19 CAR-T resistance in pre-B cell ALL can be due to the induction of a myeloid lineage switch through an epigenetic alterations in master regulators...

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Autores principales:	Elad Jacoby, Sang M. Nguyen, Thomas J. Fountaine, Kathryn Welp, Berkley Gryder, Haiying Qin, Yinmeng Yang, Christopher D. Chien, Alix E. Seif, Haiyan Lei, Young K. Song, Javed Khan, Daniel W. Lee, Crystal L. Mackall, Rebecca A. Gardner, Michael C. Jensen, Jack F. Shern, Terry J. Fry
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/97b2ab47d3724d76ba75fa902257a2ba
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spelling	oai:doaj.org-article:97b2ab47d3724d76ba75fa902257a2ba2021-12-02T17:32:53ZCD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity10.1038/ncomms123202041-1723https://doaj.org/article/97b2ab47d3724d76ba75fa902257a2ba2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12320https://doaj.org/toc/2041-1723CAR-T targeting CD19 have been successfully used in a variety of B-cell malignancies but patients may eventually relapse. Here, the authors show that CD19 CAR-T resistance in pre-B cell ALL can be due to the induction of a myeloid lineage switch through an epigenetic alterations in master regulators of B cell development.Elad JacobySang M. NguyenThomas J. FountaineKathryn WelpBerkley GryderHaiying QinYinmeng YangChristopher D. ChienAlix E. SeifHaiyan LeiYoung K. SongJaved KhanDaniel W. LeeCrystal L. MackallRebecca A. GardnerMichael C. JensenJack F. ShernTerry J. FryNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elad Jacoby Sang M. Nguyen Thomas J. Fountaine Kathryn Welp Berkley Gryder Haiying Qin Yinmeng Yang Christopher D. Chien Alix E. Seif Haiyan Lei Young K. Song Javed Khan Daniel W. Lee Crystal L. Mackall Rebecca A. Gardner Michael C. Jensen Jack F. Shern Terry J. Fry CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity
description	CAR-T targeting CD19 have been successfully used in a variety of B-cell malignancies but patients may eventually relapse. Here, the authors show that CD19 CAR-T resistance in pre-B cell ALL can be due to the induction of a myeloid lineage switch through an epigenetic alterations in master regulators of B cell development.
format	article
author	Elad Jacoby Sang M. Nguyen Thomas J. Fountaine Kathryn Welp Berkley Gryder Haiying Qin Yinmeng Yang Christopher D. Chien Alix E. Seif Haiyan Lei Young K. Song Javed Khan Daniel W. Lee Crystal L. Mackall Rebecca A. Gardner Michael C. Jensen Jack F. Shern Terry J. Fry
author_facet	Elad Jacoby Sang M. Nguyen Thomas J. Fountaine Kathryn Welp Berkley Gryder Haiying Qin Yinmeng Yang Christopher D. Chien Alix E. Seif Haiyan Lei Young K. Song Javed Khan Daniel W. Lee Crystal L. Mackall Rebecca A. Gardner Michael C. Jensen Jack F. Shern Terry J. Fry
author_sort	Elad Jacoby
title	CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity
title_short	CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity
title_full	CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity
title_fullStr	CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity
title_full_unstemmed	CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity
title_sort	cd19 car immune pressure induces b-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/97b2ab47d3724d76ba75fa902257a2ba
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CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity

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