Large-Scale Functional Networks, Cognition and Brain Structures Supporting Social Cognition and Theory of Mind Performance in Prodromal to Mild Alzheimer’s Disease

Impairment of social cognition (SC) skills such as recognition and attribution of intentions and affective states of others (Theory of Mind, ToM) has been evidenced in Alzheimer’s Disease (AD). This study investigated the neuropsychological, neuroanatomical and brain-functional underpinnings of SC p...

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Autores principales:	Jose Manuel Valera-Bermejo, Matteo De Marco, Micaela Mitolo, Chiara Cerami, Alessandra Dodich, Annalena Venneri
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Alzheimer’s disease social cognition theory of mind fMRI VBM mild cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/97b3e0132574413c9b0f87da4ed37e9d
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spelling	oai:doaj.org-article:97b3e0132574413c9b0f87da4ed37e9d2021-11-17T16:29:00ZLarge-Scale Functional Networks, Cognition and Brain Structures Supporting Social Cognition and Theory of Mind Performance in Prodromal to Mild Alzheimer’s Disease1663-436510.3389/fnagi.2021.766703https://doaj.org/article/97b3e0132574413c9b0f87da4ed37e9d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.766703/fullhttps://doaj.org/toc/1663-4365Impairment of social cognition (SC) skills such as recognition and attribution of intentions and affective states of others (Theory of Mind, ToM) has been evidenced in Alzheimer’s Disease (AD). This study investigated the neuropsychological, neuroanatomical and brain-functional underpinnings of SC processing to obtain an understanding of the social neurophenotype in early probable AD. Forty-six patients with mild cognitive impairment and mild probable AD underwent SC assessment including emotion recognition (Ekman-60-faces task) and cognitive and affective ToM (Reading-the-Mind-in-the-Eyes test and Story-based Empathy task). Linear models tested the association between SC scores and neuropsychological measures, grey matter maps and large-scale functional networks activity. The executive domain had the most predominant association with SC scores in the cognitive profile. Grey matter volume of the anterior cingulate, orbitofrontal, temporoparietal junction (TPJ), superior temporal, and cerebellar cortices were associated with ToM. Social cognition scores were associated with lower connectivity of the default-mode network with the prefrontal cortex. The right fronto-parietal network displayed higher inter-network connectivity in the right TPJ and insula while the salience network showed lower inter-network connectivity with the left TPJ and insula. Connectivity coupling alterations of executive-attentional networks may support default mode social-cognitive-associated decline through the recruitment of frontal executive mechanisms.Jose Manuel Valera-BermejoMatteo De MarcoMicaela MitoloChiara CeramiChiara CeramiAlessandra DodichAnnalena VenneriAnnalena VenneriFrontiers Media S.A.articleAlzheimer’s diseasesocial cognitiontheory of mindfMRIVBMmild cognitive impairmentNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer’s disease social cognition theory of mind fMRI VBM mild cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Alzheimer’s disease social cognition theory of mind fMRI VBM mild cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Jose Manuel Valera-Bermejo Matteo De Marco Micaela Mitolo Chiara Cerami Chiara Cerami Alessandra Dodich Annalena Venneri Annalena Venneri Large-Scale Functional Networks, Cognition and Brain Structures Supporting Social Cognition and Theory of Mind Performance in Prodromal to Mild Alzheimer’s Disease
description	Impairment of social cognition (SC) skills such as recognition and attribution of intentions and affective states of others (Theory of Mind, ToM) has been evidenced in Alzheimer’s Disease (AD). This study investigated the neuropsychological, neuroanatomical and brain-functional underpinnings of SC processing to obtain an understanding of the social neurophenotype in early probable AD. Forty-six patients with mild cognitive impairment and mild probable AD underwent SC assessment including emotion recognition (Ekman-60-faces task) and cognitive and affective ToM (Reading-the-Mind-in-the-Eyes test and Story-based Empathy task). Linear models tested the association between SC scores and neuropsychological measures, grey matter maps and large-scale functional networks activity. The executive domain had the most predominant association with SC scores in the cognitive profile. Grey matter volume of the anterior cingulate, orbitofrontal, temporoparietal junction (TPJ), superior temporal, and cerebellar cortices were associated with ToM. Social cognition scores were associated with lower connectivity of the default-mode network with the prefrontal cortex. The right fronto-parietal network displayed higher inter-network connectivity in the right TPJ and insula while the salience network showed lower inter-network connectivity with the left TPJ and insula. Connectivity coupling alterations of executive-attentional networks may support default mode social-cognitive-associated decline through the recruitment of frontal executive mechanisms.
format	article
author	Jose Manuel Valera-Bermejo Matteo De Marco Micaela Mitolo Chiara Cerami Chiara Cerami Alessandra Dodich Annalena Venneri Annalena Venneri
author_facet	Jose Manuel Valera-Bermejo Matteo De Marco Micaela Mitolo Chiara Cerami Chiara Cerami Alessandra Dodich Annalena Venneri Annalena Venneri
author_sort	Jose Manuel Valera-Bermejo
title	Large-Scale Functional Networks, Cognition and Brain Structures Supporting Social Cognition and Theory of Mind Performance in Prodromal to Mild Alzheimer’s Disease
title_short	Large-Scale Functional Networks, Cognition and Brain Structures Supporting Social Cognition and Theory of Mind Performance in Prodromal to Mild Alzheimer’s Disease
title_full	Large-Scale Functional Networks, Cognition and Brain Structures Supporting Social Cognition and Theory of Mind Performance in Prodromal to Mild Alzheimer’s Disease
title_fullStr	Large-Scale Functional Networks, Cognition and Brain Structures Supporting Social Cognition and Theory of Mind Performance in Prodromal to Mild Alzheimer’s Disease
title_full_unstemmed	Large-Scale Functional Networks, Cognition and Brain Structures Supporting Social Cognition and Theory of Mind Performance in Prodromal to Mild Alzheimer’s Disease
title_sort	large-scale functional networks, cognition and brain structures supporting social cognition and theory of mind performance in prodromal to mild alzheimer’s disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/97b3e0132574413c9b0f87da4ed37e9d
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Large-Scale Functional Networks, Cognition and Brain Structures Supporting Social Cognition and Theory of Mind Performance in Prodromal to Mild Alzheimer’s Disease

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