Variant Aldehyde Dehydrogenase 2 (<i>ALDH2*2</i>) as a Risk Factor for Mechanical LA Substrate Formation and Atrial Fibrillation with Modest Alcohol Consumption in Ethnic Asians
Aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism is a common genetic variant in Asians that is responsible for defective toxic aldehyde and lipid peroxidation metabolism after alcohol consumption. The extent to which low alcohol consumption may cause atrial substrates to trigger atrial fibrillati...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/97b4fcb1a4204bf69809b867b37e51db |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:97b4fcb1a4204bf69809b867b37e51db |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:97b4fcb1a4204bf69809b867b37e51db2021-11-25T16:51:51ZVariant Aldehyde Dehydrogenase 2 (<i>ALDH2*2</i>) as a Risk Factor for Mechanical LA Substrate Formation and Atrial Fibrillation with Modest Alcohol Consumption in Ethnic Asians10.3390/biom111115592218-273Xhttps://doaj.org/article/97b4fcb1a4204bf69809b867b37e51db2021-10-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1559https://doaj.org/toc/2218-273XAldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism is a common genetic variant in Asians that is responsible for defective toxic aldehyde and lipid peroxidation metabolism after alcohol consumption. The extent to which low alcohol consumption may cause atrial substrates to trigger atrial fibrillation (AF) development in users with ALDH2 variants remains to be determined. We prospectively enrolled 249 ethnic Asians, including 56 non-drinkers and 193 habitual drinkers (135 (70%) as ALDH2 wild-type: GG, rs671; 58 (30%) as ALDH2 variants: G/A or A/A, rs671). Novel left atrial (LA) mechanical substrates with dynamic characteristics were assessed using a speckle-tracking algorithm and correlated to daily alcohol consumption and ALDH2 genotypes. Despite modest and comparable alcohol consumption by the habitual alcohol users (14.3 [8.3~28.6] and 12.3 [6.3~30.7] g/day for those without and with ALDH2 polymorphism, <i>p</i> = 0.31), there was a substantial and graded increase in the 4-HNE adduct and prolonged PR, and a reduction in novel LA mechanical parameters (including peak atrial longitudinal strain (PALS) and phasic strain rates (reservoir, conduit, and booster pump functions), <i>p</i> < 0.05), rather than an LA emptying fraction (LAEF) or LA volume index across non-drinkers, and in habitual drinkers without and with ALDH2 polymorphism (all <i>p</i> < 0.05). The presence of ALDH2 polymorphism worsened the association between increasing daily alcohol dose and LAEF, PALS, and phasic reservoir and booster functions (all P<i><sub>interaction</sub></i>: <0.05). Binge drinking superimposed on regular alcohol use exclusively further worsened LA booster pump function compared to regular drinking without binge use (1.66 ± 0.57 vs. 1.97 ± 0.56 1/s, <i>p</i> = 0.001). Impaired LA booster function further independently helped to predict AF after consideration of the CHARGE-AF score (adjusted 1.68 (95% CI: 1.06–2.67), <i>p</i> = 0.028, per 1 z-score increment). Habitual modest alcohol consumption led to mechanical LA substrate formation in an ethnic Asian population, which was more pronounced in subjects harboring ALDH2 variants. Impaired LA booster functions may serve as a useful predictor of AF in such populations.Chung-Lieh HungKuo-Tzu SungShun-Chuan ChangYen-Yu LiuJen-Yuan KuoWen-Hung HuangCheng-Huang SuChuan-Chuan LiuShin-Yi TsaiChia-Yuan LiuAn-Sheng LeeSzu-Hua PanShih-Wei WangCharles Jia-Yin HouTa-Chuan HungHung-I YehMDPI AGarticlealdehyde dehydrogenase 2 (ALDH2)alcoholaldehyde4-hydroxynonenal (4-HNE)peak atrial longitudinal strain (PALS)strain ratesMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1559, p 1559 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
aldehyde dehydrogenase 2 (ALDH2) alcohol aldehyde 4-hydroxynonenal (4-HNE) peak atrial longitudinal strain (PALS) strain rates Microbiology QR1-502 |
| spellingShingle |
aldehyde dehydrogenase 2 (ALDH2) alcohol aldehyde 4-hydroxynonenal (4-HNE) peak atrial longitudinal strain (PALS) strain rates Microbiology QR1-502 Chung-Lieh Hung Kuo-Tzu Sung Shun-Chuan Chang Yen-Yu Liu Jen-Yuan Kuo Wen-Hung Huang Cheng-Huang Su Chuan-Chuan Liu Shin-Yi Tsai Chia-Yuan Liu An-Sheng Lee Szu-Hua Pan Shih-Wei Wang Charles Jia-Yin Hou Ta-Chuan Hung Hung-I Yeh Variant Aldehyde Dehydrogenase 2 (<i>ALDH2*2</i>) as a Risk Factor for Mechanical LA Substrate Formation and Atrial Fibrillation with Modest Alcohol Consumption in Ethnic Asians |
| description |
Aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism is a common genetic variant in Asians that is responsible for defective toxic aldehyde and lipid peroxidation metabolism after alcohol consumption. The extent to which low alcohol consumption may cause atrial substrates to trigger atrial fibrillation (AF) development in users with ALDH2 variants remains to be determined. We prospectively enrolled 249 ethnic Asians, including 56 non-drinkers and 193 habitual drinkers (135 (70%) as ALDH2 wild-type: GG, rs671; 58 (30%) as ALDH2 variants: G/A or A/A, rs671). Novel left atrial (LA) mechanical substrates with dynamic characteristics were assessed using a speckle-tracking algorithm and correlated to daily alcohol consumption and ALDH2 genotypes. Despite modest and comparable alcohol consumption by the habitual alcohol users (14.3 [8.3~28.6] and 12.3 [6.3~30.7] g/day for those without and with ALDH2 polymorphism, <i>p</i> = 0.31), there was a substantial and graded increase in the 4-HNE adduct and prolonged PR, and a reduction in novel LA mechanical parameters (including peak atrial longitudinal strain (PALS) and phasic strain rates (reservoir, conduit, and booster pump functions), <i>p</i> < 0.05), rather than an LA emptying fraction (LAEF) or LA volume index across non-drinkers, and in habitual drinkers without and with ALDH2 polymorphism (all <i>p</i> < 0.05). The presence of ALDH2 polymorphism worsened the association between increasing daily alcohol dose and LAEF, PALS, and phasic reservoir and booster functions (all P<i><sub>interaction</sub></i>: <0.05). Binge drinking superimposed on regular alcohol use exclusively further worsened LA booster pump function compared to regular drinking without binge use (1.66 ± 0.57 vs. 1.97 ± 0.56 1/s, <i>p</i> = 0.001). Impaired LA booster function further independently helped to predict AF after consideration of the CHARGE-AF score (adjusted 1.68 (95% CI: 1.06–2.67), <i>p</i> = 0.028, per 1 z-score increment). Habitual modest alcohol consumption led to mechanical LA substrate formation in an ethnic Asian population, which was more pronounced in subjects harboring ALDH2 variants. Impaired LA booster functions may serve as a useful predictor of AF in such populations. |
| format |
article |
| author |
Chung-Lieh Hung Kuo-Tzu Sung Shun-Chuan Chang Yen-Yu Liu Jen-Yuan Kuo Wen-Hung Huang Cheng-Huang Su Chuan-Chuan Liu Shin-Yi Tsai Chia-Yuan Liu An-Sheng Lee Szu-Hua Pan Shih-Wei Wang Charles Jia-Yin Hou Ta-Chuan Hung Hung-I Yeh |
| author_facet |
Chung-Lieh Hung Kuo-Tzu Sung Shun-Chuan Chang Yen-Yu Liu Jen-Yuan Kuo Wen-Hung Huang Cheng-Huang Su Chuan-Chuan Liu Shin-Yi Tsai Chia-Yuan Liu An-Sheng Lee Szu-Hua Pan Shih-Wei Wang Charles Jia-Yin Hou Ta-Chuan Hung Hung-I Yeh |
| author_sort |
Chung-Lieh Hung |
| title |
Variant Aldehyde Dehydrogenase 2 (<i>ALDH2*2</i>) as a Risk Factor for Mechanical LA Substrate Formation and Atrial Fibrillation with Modest Alcohol Consumption in Ethnic Asians |
| title_short |
Variant Aldehyde Dehydrogenase 2 (<i>ALDH2*2</i>) as a Risk Factor for Mechanical LA Substrate Formation and Atrial Fibrillation with Modest Alcohol Consumption in Ethnic Asians |
| title_full |
Variant Aldehyde Dehydrogenase 2 (<i>ALDH2*2</i>) as a Risk Factor for Mechanical LA Substrate Formation and Atrial Fibrillation with Modest Alcohol Consumption in Ethnic Asians |
| title_fullStr |
Variant Aldehyde Dehydrogenase 2 (<i>ALDH2*2</i>) as a Risk Factor for Mechanical LA Substrate Formation and Atrial Fibrillation with Modest Alcohol Consumption in Ethnic Asians |
| title_full_unstemmed |
Variant Aldehyde Dehydrogenase 2 (<i>ALDH2*2</i>) as a Risk Factor for Mechanical LA Substrate Formation and Atrial Fibrillation with Modest Alcohol Consumption in Ethnic Asians |
| title_sort |
variant aldehyde dehydrogenase 2 (<i>aldh2*2</i>) as a risk factor for mechanical la substrate formation and atrial fibrillation with modest alcohol consumption in ethnic asians |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/97b4fcb1a4204bf69809b867b37e51db |
| work_keys_str_mv |
AT chungliehhung variantaldehydedehydrogenase2ialdh22iasariskfactorformechanicallasubstrateformationandatrialfibrillationwithmodestalcoholconsumptioninethnicasians AT kuotzusung variantaldehydedehydrogenase2ialdh22iasariskfactorformechanicallasubstrateformationandatrialfibrillationwithmodestalcoholconsumptioninethnicasians AT shunchuanchang variantaldehydedehydrogenase2ialdh22iasariskfactorformechanicallasubstrateformationandatrialfibrillationwithmodestalcoholconsumptioninethnicasians AT yenyuliu variantaldehydedehydrogenase2ialdh22iasariskfactorformechanicallasubstrateformationandatrialfibrillationwithmodestalcoholconsumptioninethnicasians AT jenyuankuo variantaldehydedehydrogenase2ialdh22iasariskfactorformechanicallasubstrateformationandatrialfibrillationwithmodestalcoholconsumptioninethnicasians AT wenhunghuang variantaldehydedehydrogenase2ialdh22iasariskfactorformechanicallasubstrateformationandatrialfibrillationwithmodestalcoholconsumptioninethnicasians AT chenghuangsu variantaldehydedehydrogenase2ialdh22iasariskfactorformechanicallasubstrateformationandatrialfibrillationwithmodestalcoholconsumptioninethnicasians AT chuanchuanliu variantaldehydedehydrogenase2ialdh22iasariskfactorformechanicallasubstrateformationandatrialfibrillationwithmodestalcoholconsumptioninethnicasians AT shinyitsai variantaldehydedehydrogenase2ialdh22iasariskfactorformechanicallasubstrateformationandatrialfibrillationwithmodestalcoholconsumptioninethnicasians AT chiayuanliu variantaldehydedehydrogenase2ialdh22iasariskfactorformechanicallasubstrateformationandatrialfibrillationwithmodestalcoholconsumptioninethnicasians AT anshenglee variantaldehydedehydrogenase2ialdh22iasariskfactorformechanicallasubstrateformationandatrialfibrillationwithmodestalcoholconsumptioninethnicasians AT szuhuapan variantaldehydedehydrogenase2ialdh22iasariskfactorformechanicallasubstrateformationandatrialfibrillationwithmodestalcoholconsumptioninethnicasians AT shihweiwang variantaldehydedehydrogenase2ialdh22iasariskfactorformechanicallasubstrateformationandatrialfibrillationwithmodestalcoholconsumptioninethnicasians AT charlesjiayinhou variantaldehydedehydrogenase2ialdh22iasariskfactorformechanicallasubstrateformationandatrialfibrillationwithmodestalcoholconsumptioninethnicasians AT tachuanhung variantaldehydedehydrogenase2ialdh22iasariskfactorformechanicallasubstrateformationandatrialfibrillationwithmodestalcoholconsumptioninethnicasians AT hungiyeh variantaldehydedehydrogenase2ialdh22iasariskfactorformechanicallasubstrateformationandatrialfibrillationwithmodestalcoholconsumptioninethnicasians |
| _version_ |
1718412910080819200 |