Melinjo seed extract stimulates intestinal ABCG2 expression to reduce serum uric acid levels in hyperuricemic rats

Melinjo resveratrol (MjR) is a resveratrol derivative from the seed extract of melinjo (Gnetum gnemon L.). Although it may reduce serum uric acid concentration in humans, the underlying mechanism remains unclear. Thus, we investigated the effect of MjR on the uric acid metabolism in the setting of h...

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Autores principales:	Yoshifuru Tamura, Chikayuki Morimoto, Emiko Kuribayashi-Okuma, Shunya Uchida, Makoto Hosoyamada, Takahiko Nakagawa, Shigeru Shibata
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Hyperuricemia Melinjo ABCG2 Ileum Extrarenal excretion Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/97b5cb590edf426780bb7761c0a36d5d
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spelling	oai:doaj.org-article:97b5cb590edf426780bb7761c0a36d5d2021-11-16T04:09:27ZMelinjo seed extract stimulates intestinal ABCG2 expression to reduce serum uric acid levels in hyperuricemic rats1756-464610.1016/j.jff.2021.104849https://doaj.org/article/97b5cb590edf426780bb7761c0a36d5d2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1756464621004989https://doaj.org/toc/1756-4646Melinjo resveratrol (MjR) is a resveratrol derivative from the seed extract of melinjo (Gnetum gnemon L.). Although it may reduce serum uric acid concentration in humans, the underlying mechanism remains unclear. Thus, we investigated the effect of MjR on the uric acid metabolism in the setting of hyperuricemia model rats induced by orally administered oxonic acid. MjR administered for three weeks significantly lowered serum uric acid levels in hyperuricemia rats. While urinary excretion of uric acid did not change, fecal excretion of uric acid significantly increased by MjR. The expression of ATP-binding cassette sub-family G member (ABCG2) was upregulated with MjR treatment in the ileum but not in the kidney. In a human epithelial colorectal cell line, Caco-2, uric acid and MjR additively stimulated ABCG2 expression. These data suggest that MjR could reduce serum uric acid by enhancing fecal excretion of uric acid in the ileum by upregulating ABCG2 protein expression.Yoshifuru TamuraChikayuki MorimotoEmiko Kuribayashi-OkumaShunya UchidaMakoto HosoyamadaTakahiko NakagawaShigeru ShibataElsevierarticleHyperuricemiaMelinjoABCG2IleumExtrarenal excretionNutrition. Foods and food supplyTX341-641ENJournal of Functional Foods, Vol 87, Iss , Pp 104849- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hyperuricemia Melinjo ABCG2 Ileum Extrarenal excretion Nutrition. Foods and food supply TX341-641
spellingShingle	Hyperuricemia Melinjo ABCG2 Ileum Extrarenal excretion Nutrition. Foods and food supply TX341-641 Yoshifuru Tamura Chikayuki Morimoto Emiko Kuribayashi-Okuma Shunya Uchida Makoto Hosoyamada Takahiko Nakagawa Shigeru Shibata Melinjo seed extract stimulates intestinal ABCG2 expression to reduce serum uric acid levels in hyperuricemic rats
description	Melinjo resveratrol (MjR) is a resveratrol derivative from the seed extract of melinjo (Gnetum gnemon L.). Although it may reduce serum uric acid concentration in humans, the underlying mechanism remains unclear. Thus, we investigated the effect of MjR on the uric acid metabolism in the setting of hyperuricemia model rats induced by orally administered oxonic acid. MjR administered for three weeks significantly lowered serum uric acid levels in hyperuricemia rats. While urinary excretion of uric acid did not change, fecal excretion of uric acid significantly increased by MjR. The expression of ATP-binding cassette sub-family G member (ABCG2) was upregulated with MjR treatment in the ileum but not in the kidney. In a human epithelial colorectal cell line, Caco-2, uric acid and MjR additively stimulated ABCG2 expression. These data suggest that MjR could reduce serum uric acid by enhancing fecal excretion of uric acid in the ileum by upregulating ABCG2 protein expression.
format	article
author	Yoshifuru Tamura Chikayuki Morimoto Emiko Kuribayashi-Okuma Shunya Uchida Makoto Hosoyamada Takahiko Nakagawa Shigeru Shibata
author_facet	Yoshifuru Tamura Chikayuki Morimoto Emiko Kuribayashi-Okuma Shunya Uchida Makoto Hosoyamada Takahiko Nakagawa Shigeru Shibata
author_sort	Yoshifuru Tamura
title	Melinjo seed extract stimulates intestinal ABCG2 expression to reduce serum uric acid levels in hyperuricemic rats
title_short	Melinjo seed extract stimulates intestinal ABCG2 expression to reduce serum uric acid levels in hyperuricemic rats
title_full	Melinjo seed extract stimulates intestinal ABCG2 expression to reduce serum uric acid levels in hyperuricemic rats
title_fullStr	Melinjo seed extract stimulates intestinal ABCG2 expression to reduce serum uric acid levels in hyperuricemic rats
title_full_unstemmed	Melinjo seed extract stimulates intestinal ABCG2 expression to reduce serum uric acid levels in hyperuricemic rats
title_sort	melinjo seed extract stimulates intestinal abcg2 expression to reduce serum uric acid levels in hyperuricemic rats
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/97b5cb590edf426780bb7761c0a36d5d
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Melinjo seed extract stimulates intestinal ABCG2 expression to reduce serum uric acid levels in hyperuricemic rats

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