Pre- and postnatal determinants of deciduous molar hypomineralisation in 6-year-old children. The generation R study.

<h4>Background</h4>Deciduous Molar Hypomineralisation (DMH) and Molar Incisor Hypomineralisation (MIH) are common developmental disturbances in pediatric dentistry. Their occurrence is related. The same determinants as suggested for MIH are expected for DMH, though somewhat earlier in li...

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Autores principales:	Marlies E C Elfrink, Henriette A Moll, Jessica C Kiefte-de Jong, Vincent W V Jaddoe, Albert Hofman, Jacob M ten Cate, Jaap S J Veerkamp
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/97b7bcfbd92c471588625691ea11fe28
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spelling	oai:doaj.org-article:97b7bcfbd92c471588625691ea11fe282021-11-25T06:09:52ZPre- and postnatal determinants of deciduous molar hypomineralisation in 6-year-old children. The generation R study.1932-620310.1371/journal.pone.0091057https://doaj.org/article/97b7bcfbd92c471588625691ea11fe282014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24988443/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Deciduous Molar Hypomineralisation (DMH) and Molar Incisor Hypomineralisation (MIH) are common developmental disturbances in pediatric dentistry. Their occurrence is related. The same determinants as suggested for MIH are expected for DMH, though somewhat earlier in life. Perinatal medical problems may influence the prevalence of DMH but this has not been studied sufficiently.<h4>Objective</h4>This study aimed to identify possible determinants of DMH in a prospective cohort study among 6-year-old children.<h4>Study design</h4>This study was embedded in the Generation R Study, a population-based prospective cohort study from fetal life until young adulthood. The the data were used to identify the determinants of DMH. Clinical photographs of clean, moist teeth were taken with an intra-oral camera in 6690 children (mean age 6.2 years; 49.9% girls). Data on possible determinants that had occurred during pregnancy and/or the child's first year of life were on the basis of manual standardized measurements (like length and weight) and questionnaires. Multivariate analyse with backward and forward selection was performed.<h4>Results</h4>A number of factors in the pre-, peri- and postnatal phase were found to be associated with DMH. After multivariate logistic regression analyses, Dutch ethnic background, low birth weight, maternal alcohol consumption during pregnancy, and fever episodes in the first year of the child's life were found to play a role in the development of DMH in 6-year-old children.<h4>Conclusion</h4>This study shows that Dutch ethnicity, low birth weight, alcohol consumption by the mother during pregnancy and any fever in the first year of the child's life are associated with DMH. Not only childhood factors but also prenatal lifestyle factors need to be taken into account when studying determinants for DMH.Marlies E C ElfrinkHenriette A MollJessica C Kiefte-de JongVincent W V JaddoeAlbert HofmanJacob M ten CateJaap S J VeerkampPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 7, p e91057 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marlies E C Elfrink Henriette A Moll Jessica C Kiefte-de Jong Vincent W V Jaddoe Albert Hofman Jacob M ten Cate Jaap S J Veerkamp Pre- and postnatal determinants of deciduous molar hypomineralisation in 6-year-old children. The generation R study.
description	<h4>Background</h4>Deciduous Molar Hypomineralisation (DMH) and Molar Incisor Hypomineralisation (MIH) are common developmental disturbances in pediatric dentistry. Their occurrence is related. The same determinants as suggested for MIH are expected for DMH, though somewhat earlier in life. Perinatal medical problems may influence the prevalence of DMH but this has not been studied sufficiently.<h4>Objective</h4>This study aimed to identify possible determinants of DMH in a prospective cohort study among 6-year-old children.<h4>Study design</h4>This study was embedded in the Generation R Study, a population-based prospective cohort study from fetal life until young adulthood. The the data were used to identify the determinants of DMH. Clinical photographs of clean, moist teeth were taken with an intra-oral camera in 6690 children (mean age 6.2 years; 49.9% girls). Data on possible determinants that had occurred during pregnancy and/or the child's first year of life were on the basis of manual standardized measurements (like length and weight) and questionnaires. Multivariate analyse with backward and forward selection was performed.<h4>Results</h4>A number of factors in the pre-, peri- and postnatal phase were found to be associated with DMH. After multivariate logistic regression analyses, Dutch ethnic background, low birth weight, maternal alcohol consumption during pregnancy, and fever episodes in the first year of the child's life were found to play a role in the development of DMH in 6-year-old children.<h4>Conclusion</h4>This study shows that Dutch ethnicity, low birth weight, alcohol consumption by the mother during pregnancy and any fever in the first year of the child's life are associated with DMH. Not only childhood factors but also prenatal lifestyle factors need to be taken into account when studying determinants for DMH.
format	article
author	Marlies E C Elfrink Henriette A Moll Jessica C Kiefte-de Jong Vincent W V Jaddoe Albert Hofman Jacob M ten Cate Jaap S J Veerkamp
author_facet	Marlies E C Elfrink Henriette A Moll Jessica C Kiefte-de Jong Vincent W V Jaddoe Albert Hofman Jacob M ten Cate Jaap S J Veerkamp
author_sort	Marlies E C Elfrink
title	Pre- and postnatal determinants of deciduous molar hypomineralisation in 6-year-old children. The generation R study.
title_short	Pre- and postnatal determinants of deciduous molar hypomineralisation in 6-year-old children. The generation R study.
title_full	Pre- and postnatal determinants of deciduous molar hypomineralisation in 6-year-old children. The generation R study.
title_fullStr	Pre- and postnatal determinants of deciduous molar hypomineralisation in 6-year-old children. The generation R study.
title_full_unstemmed	Pre- and postnatal determinants of deciduous molar hypomineralisation in 6-year-old children. The generation R study.
title_sort	pre- and postnatal determinants of deciduous molar hypomineralisation in 6-year-old children. the generation r study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/97b7bcfbd92c471588625691ea11fe28
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Pre- and postnatal determinants of deciduous molar hypomineralisation in 6-year-old children. The generation R study.

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