Choriocapillaris Vascular Density Changes: Healthy vs. Advanced Exudative Age-Related Macular Degeneration Previously Treated with Multiple Anti-VEGF Intravitreal Injections

Purpose: To assess choriocapillaris vascular density (VD) in healthy and advanced exudative age-related macular degeneration (ae-AMD) patients by new full-range optical coherence tomography angiography (OCT-A). Method: In this observational, cross-sectional study, 21 healthy and 21 ae-AMD eyes, alre...

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Autores principales:	Maria Cristina Savastano, Clara Rizzo, Gloria Gambini, Alfonso Savastano, Benedetto Falsini, Daniela Bacherini, Carmela Grazia Caputo, Raphael Kilian, Francesco Faraldi, Umberto De Vico, Stanislao Rizzo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	advanced exudative AMD age-related macular degeneration innovative biotechnologies macular neovascularization OCT angiography personalized medicine Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/97b93d5650fa47c186c783acb1de4383
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spelling	oai:doaj.org-article:97b93d5650fa47c186c783acb1de43832021-11-25T17:20:14ZChoriocapillaris Vascular Density Changes: Healthy vs. Advanced Exudative Age-Related Macular Degeneration Previously Treated with Multiple Anti-VEGF Intravitreal Injections10.3390/diagnostics111119582075-4418https://doaj.org/article/97b93d5650fa47c186c783acb1de43832021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/1958https://doaj.org/toc/2075-4418Purpose: To assess choriocapillaris vascular density (VD) in healthy and advanced exudative age-related macular degeneration (ae-AMD) patients by new full-range optical coherence tomography angiography (OCT-A). Method: In this observational, cross-sectional study, 21 healthy and 21 ae-AMD eyes, already treated with anti-VEGF, were enrolled. Angio-View retina patterns centered on fovea (6.4 × 6.4 mm) were acquired for all participants using Solix full-range OCT (Optovue Inc., Freemont, CA, USA). The main outcome was to compare choriocapillaris VD between healthy and ae-AMD eyes. Automated measurements of whole image choriocapillaris VD (%) and fovea grid-based (%) were collected for the analysis. Angio-View patterns were used to assess the flow area (mm<sup>2</sup>) of macular neovascularization (MNV) by contour flow measure algorithm. Best-corrected visual acuity (BCVA) of both groups was also used for the statistical analysis. Results: The mean age was 60.9 (±8.3) in healthy and 73.33 (±15.05) in ae-AMD eyes. The mean BCVA (ETDRS letters) was 98.47 (±1.50) in healthy and 7.04 (±5.96) in ae-AMD eyes. The Mann–Whitney test comparing choriocapillaries VD for whole and fovea healthy and ae-AMD eyes showed statistical significance (<i>p</i> < 0.0001 (t = 4.91; df = 40) and <i>p</i> < 0.0001 (t = 6.84; df = 40), respectively). Regarding, the correlation between MNV and VD of choriocapillaries, neither whole nor fovea areas were statistically significant (F = 0.38 (R<sup>2</sup> = 0.01) and 1.68 (R<sup>2</sup> = 0.08), respectively). Conclusions: Choriocapillaris VD showed a statistically significant reduction in comparison to healthy eyes in ae-AMD eyes. Choriocapillaris impairment can be seen in the early phase of MNV pathogenesis.Maria Cristina SavastanoClara RizzoGloria GambiniAlfonso SavastanoBenedetto FalsiniDaniela BacheriniCarmela Grazia CaputoRaphael KilianFrancesco FaraldiUmberto De VicoStanislao RizzoMDPI AGarticleadvanced exudative AMDage-related macular degenerationinnovative biotechnologiesmacular neovascularizationOCT angiographypersonalized medicineMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 1958, p 1958 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	advanced exudative AMD age-related macular degeneration innovative biotechnologies macular neovascularization OCT angiography personalized medicine Medicine (General) R5-920
spellingShingle	advanced exudative AMD age-related macular degeneration innovative biotechnologies macular neovascularization OCT angiography personalized medicine Medicine (General) R5-920 Maria Cristina Savastano Clara Rizzo Gloria Gambini Alfonso Savastano Benedetto Falsini Daniela Bacherini Carmela Grazia Caputo Raphael Kilian Francesco Faraldi Umberto De Vico Stanislao Rizzo Choriocapillaris Vascular Density Changes: Healthy vs. Advanced Exudative Age-Related Macular Degeneration Previously Treated with Multiple Anti-VEGF Intravitreal Injections
description	Purpose: To assess choriocapillaris vascular density (VD) in healthy and advanced exudative age-related macular degeneration (ae-AMD) patients by new full-range optical coherence tomography angiography (OCT-A). Method: In this observational, cross-sectional study, 21 healthy and 21 ae-AMD eyes, already treated with anti-VEGF, were enrolled. Angio-View retina patterns centered on fovea (6.4 × 6.4 mm) were acquired for all participants using Solix full-range OCT (Optovue Inc., Freemont, CA, USA). The main outcome was to compare choriocapillaris VD between healthy and ae-AMD eyes. Automated measurements of whole image choriocapillaris VD (%) and fovea grid-based (%) were collected for the analysis. Angio-View patterns were used to assess the flow area (mm<sup>2</sup>) of macular neovascularization (MNV) by contour flow measure algorithm. Best-corrected visual acuity (BCVA) of both groups was also used for the statistical analysis. Results: The mean age was 60.9 (±8.3) in healthy and 73.33 (±15.05) in ae-AMD eyes. The mean BCVA (ETDRS letters) was 98.47 (±1.50) in healthy and 7.04 (±5.96) in ae-AMD eyes. The Mann–Whitney test comparing choriocapillaries VD for whole and fovea healthy and ae-AMD eyes showed statistical significance (<i>p</i> < 0.0001 (t = 4.91; df = 40) and <i>p</i> < 0.0001 (t = 6.84; df = 40), respectively). Regarding, the correlation between MNV and VD of choriocapillaries, neither whole nor fovea areas were statistically significant (F = 0.38 (R<sup>2</sup> = 0.01) and 1.68 (R<sup>2</sup> = 0.08), respectively). Conclusions: Choriocapillaris VD showed a statistically significant reduction in comparison to healthy eyes in ae-AMD eyes. Choriocapillaris impairment can be seen in the early phase of MNV pathogenesis.
format	article
author	Maria Cristina Savastano Clara Rizzo Gloria Gambini Alfonso Savastano Benedetto Falsini Daniela Bacherini Carmela Grazia Caputo Raphael Kilian Francesco Faraldi Umberto De Vico Stanislao Rizzo
author_facet	Maria Cristina Savastano Clara Rizzo Gloria Gambini Alfonso Savastano Benedetto Falsini Daniela Bacherini Carmela Grazia Caputo Raphael Kilian Francesco Faraldi Umberto De Vico Stanislao Rizzo
author_sort	Maria Cristina Savastano
title	Choriocapillaris Vascular Density Changes: Healthy vs. Advanced Exudative Age-Related Macular Degeneration Previously Treated with Multiple Anti-VEGF Intravitreal Injections
title_short	Choriocapillaris Vascular Density Changes: Healthy vs. Advanced Exudative Age-Related Macular Degeneration Previously Treated with Multiple Anti-VEGF Intravitreal Injections
title_full	Choriocapillaris Vascular Density Changes: Healthy vs. Advanced Exudative Age-Related Macular Degeneration Previously Treated with Multiple Anti-VEGF Intravitreal Injections
title_fullStr	Choriocapillaris Vascular Density Changes: Healthy vs. Advanced Exudative Age-Related Macular Degeneration Previously Treated with Multiple Anti-VEGF Intravitreal Injections
title_full_unstemmed	Choriocapillaris Vascular Density Changes: Healthy vs. Advanced Exudative Age-Related Macular Degeneration Previously Treated with Multiple Anti-VEGF Intravitreal Injections
title_sort	choriocapillaris vascular density changes: healthy vs. advanced exudative age-related macular degeneration previously treated with multiple anti-vegf intravitreal injections
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/97b93d5650fa47c186c783acb1de4383
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Choriocapillaris Vascular Density Changes: Healthy vs. Advanced Exudative Age-Related Macular Degeneration Previously Treated with Multiple Anti-VEGF Intravitreal Injections

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