Mechanism of human papillomavirus binding to human spermatozoa and fertilizing ability of infected spermatozoa.

Human papillomaviruses (HPVs) are agents of the most common sexually transmitted diseases in females and males. Precise data about the presence, mechanism of infection and clinical significance of HPV in the male reproductive tract and especially in sperm are not available. Here we show that HPV can...

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Autores principales:	Carlo Foresta, Cristina Patassini, Alessandro Bertoldo, Massimo Menegazzo, Felice Francavilla, Luisa Barzon, Alberto Ferlin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/97bb5998748d4176b105a4095f02dcf0
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spelling	oai:doaj.org-article:97bb5998748d4176b105a4095f02dcf02021-11-18T06:57:45ZMechanism of human papillomavirus binding to human spermatozoa and fertilizing ability of infected spermatozoa.1932-620310.1371/journal.pone.0015036https://doaj.org/article/97bb5998748d4176b105a4095f02dcf02011-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21408100/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Human papillomaviruses (HPVs) are agents of the most common sexually transmitted diseases in females and males. Precise data about the presence, mechanism of infection and clinical significance of HPV in the male reproductive tract and especially in sperm are not available. Here we show that HPV can infect human sperm, it localizes at the equatorial region of sperm head through interaction between the HPV capsid protein L1 and syndecan-1. Sperm transfected with HPV E6/E7 genes and sperm exposed to HPV L1 capsid protein are capable to penetrate the oocyte and transfer the virus into oocytes, in which viral genes are then activated and transcribed. These data show that sperm might function as vectors for HPV transfer into the oocytes, and open new perspectives on the role of HPV infection in males and are particularly intriguing in relation to assisted reproduction techniques.Carlo ForestaCristina PatassiniAlessandro BertoldoMassimo MenegazzoFelice FrancavillaLuisa BarzonAlberto FerlinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 3, p e15036 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carlo Foresta Cristina Patassini Alessandro Bertoldo Massimo Menegazzo Felice Francavilla Luisa Barzon Alberto Ferlin Mechanism of human papillomavirus binding to human spermatozoa and fertilizing ability of infected spermatozoa.
description	Human papillomaviruses (HPVs) are agents of the most common sexually transmitted diseases in females and males. Precise data about the presence, mechanism of infection and clinical significance of HPV in the male reproductive tract and especially in sperm are not available. Here we show that HPV can infect human sperm, it localizes at the equatorial region of sperm head through interaction between the HPV capsid protein L1 and syndecan-1. Sperm transfected with HPV E6/E7 genes and sperm exposed to HPV L1 capsid protein are capable to penetrate the oocyte and transfer the virus into oocytes, in which viral genes are then activated and transcribed. These data show that sperm might function as vectors for HPV transfer into the oocytes, and open new perspectives on the role of HPV infection in males and are particularly intriguing in relation to assisted reproduction techniques.
format	article
author	Carlo Foresta Cristina Patassini Alessandro Bertoldo Massimo Menegazzo Felice Francavilla Luisa Barzon Alberto Ferlin
author_facet	Carlo Foresta Cristina Patassini Alessandro Bertoldo Massimo Menegazzo Felice Francavilla Luisa Barzon Alberto Ferlin
author_sort	Carlo Foresta
title	Mechanism of human papillomavirus binding to human spermatozoa and fertilizing ability of infected spermatozoa.
title_short	Mechanism of human papillomavirus binding to human spermatozoa and fertilizing ability of infected spermatozoa.
title_full	Mechanism of human papillomavirus binding to human spermatozoa and fertilizing ability of infected spermatozoa.
title_fullStr	Mechanism of human papillomavirus binding to human spermatozoa and fertilizing ability of infected spermatozoa.
title_full_unstemmed	Mechanism of human papillomavirus binding to human spermatozoa and fertilizing ability of infected spermatozoa.
title_sort	mechanism of human papillomavirus binding to human spermatozoa and fertilizing ability of infected spermatozoa.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/97bb5998748d4176b105a4095f02dcf0
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Mechanism of human papillomavirus binding to human spermatozoa and fertilizing ability of infected spermatozoa.

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