Increased C reactive protein, cardiac troponin I and GLS are associated with myocardial inflammation in patients with non-ischemic heart failure

Abstract Inflammatory cardiomyopathy diagnosed by endomyocardial biopsy (EMB) is common in non-ischemic heart failure (HF) and might be associated with adverse outcome. We aimed to identify markers predicting myocardial inflammation in HF. We screened 517 patients with symptomatic non-ischemic HF wh...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	S. Schwuchow-Thonke, S. Göbel, T. Emrich, V. H. Schmitt, F. Fueting, C. Klank, F. Escher, H. P. Schultheiss, T. Münzel, K. Keller, P. Wenzel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/97bd0631699f446bb0e09d710f876b91
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:97bd0631699f446bb0e09d710f876b91
record_format	dspace
spelling	oai:doaj.org-article:97bd0631699f446bb0e09d710f876b912021-12-02T10:44:08ZIncreased C reactive protein, cardiac troponin I and GLS are associated with myocardial inflammation in patients with non-ischemic heart failure10.1038/s41598-021-82592-82045-2322https://doaj.org/article/97bd0631699f446bb0e09d710f876b912021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82592-8https://doaj.org/toc/2045-2322Abstract Inflammatory cardiomyopathy diagnosed by endomyocardial biopsy (EMB) is common in non-ischemic heart failure (HF) and might be associated with adverse outcome. We aimed to identify markers predicting myocardial inflammation in HF. We screened 517 patients with symptomatic non-ischemic HF who underwent EMB; 397 patients (median age 54 [IQR 43/64], 28.7% females) were included in this study. 230 patients were diagnosed with myocardial inflammation, defined as ≥ 7.0 CD3+ lymphocytes/mm2 and/or ≥ 35.0 Mac1 macrophages/mm2 and were compared to 167 inflammation negative patients. Patients with myocardial inflammation were more often smokers (52.4% vs. 39.8%, p = 0.013) and had higher C-reactive protein (CRP) levels (5.4 mg/dl vs. 3.7 mg/dl, p = 0.003). In logistic regression models CRP ≥ 8.15 mg/dl (OR 1.985 [95%CI 1.160–3.397]; p = 0.012) and Troponin I (TnI) ≥ 136.5 pg/ml (OR 3.011 [1.215–7.464]; p = 0.017) were independently associated with myocardial inflammation, whereas no association was found for elevated brain natriuretic peptide (OR 1.811 [0.873–3.757]; p = 0.111). In prognostic performance calculation the highest positive predictive value (90%) was detected for the combination of Global longitudinal strain (GLS) ≥ -13.95% and TnI ≥ 136.5 pg/ml (0.90 (0.74–0.96)). Elevated CRP, TnI and GLS in combination with TnI can be useful to detect myocardial inflammation. Smoking seems to predispose for myocardial inflammation.S. Schwuchow-ThonkeS. GöbelT. EmrichV. H. SchmittF. FuetingC. KlankF. EscherH. P. SchultheissT. MünzelK. KellerP. WenzelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q S. Schwuchow-Thonke S. Göbel T. Emrich V. H. Schmitt F. Fueting C. Klank F. Escher H. P. Schultheiss T. Münzel K. Keller P. Wenzel Increased C reactive protein, cardiac troponin I and GLS are associated with myocardial inflammation in patients with non-ischemic heart failure
description	Abstract Inflammatory cardiomyopathy diagnosed by endomyocardial biopsy (EMB) is common in non-ischemic heart failure (HF) and might be associated with adverse outcome. We aimed to identify markers predicting myocardial inflammation in HF. We screened 517 patients with symptomatic non-ischemic HF who underwent EMB; 397 patients (median age 54 [IQR 43/64], 28.7% females) were included in this study. 230 patients were diagnosed with myocardial inflammation, defined as ≥ 7.0 CD3+ lymphocytes/mm2 and/or ≥ 35.0 Mac1 macrophages/mm2 and were compared to 167 inflammation negative patients. Patients with myocardial inflammation were more often smokers (52.4% vs. 39.8%, p = 0.013) and had higher C-reactive protein (CRP) levels (5.4 mg/dl vs. 3.7 mg/dl, p = 0.003). In logistic regression models CRP ≥ 8.15 mg/dl (OR 1.985 [95%CI 1.160–3.397]; p = 0.012) and Troponin I (TnI) ≥ 136.5 pg/ml (OR 3.011 [1.215–7.464]; p = 0.017) were independently associated with myocardial inflammation, whereas no association was found for elevated brain natriuretic peptide (OR 1.811 [0.873–3.757]; p = 0.111). In prognostic performance calculation the highest positive predictive value (90%) was detected for the combination of Global longitudinal strain (GLS) ≥ -13.95% and TnI ≥ 136.5 pg/ml (0.90 (0.74–0.96)). Elevated CRP, TnI and GLS in combination with TnI can be useful to detect myocardial inflammation. Smoking seems to predispose for myocardial inflammation.
format	article
author	S. Schwuchow-Thonke S. Göbel T. Emrich V. H. Schmitt F. Fueting C. Klank F. Escher H. P. Schultheiss T. Münzel K. Keller P. Wenzel
author_facet	S. Schwuchow-Thonke S. Göbel T. Emrich V. H. Schmitt F. Fueting C. Klank F. Escher H. P. Schultheiss T. Münzel K. Keller P. Wenzel
author_sort	S. Schwuchow-Thonke
title	Increased C reactive protein, cardiac troponin I and GLS are associated with myocardial inflammation in patients with non-ischemic heart failure
title_short	Increased C reactive protein, cardiac troponin I and GLS are associated with myocardial inflammation in patients with non-ischemic heart failure
title_full	Increased C reactive protein, cardiac troponin I and GLS are associated with myocardial inflammation in patients with non-ischemic heart failure
title_fullStr	Increased C reactive protein, cardiac troponin I and GLS are associated with myocardial inflammation in patients with non-ischemic heart failure
title_full_unstemmed	Increased C reactive protein, cardiac troponin I and GLS are associated with myocardial inflammation in patients with non-ischemic heart failure
title_sort	increased c reactive protein, cardiac troponin i and gls are associated with myocardial inflammation in patients with non-ischemic heart failure
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/97bd0631699f446bb0e09d710f876b91
work_keys_str_mv	AT sschwuchowthonke increasedcreactiveproteincardiactroponiniandglsareassociatedwithmyocardialinflammationinpatientswithnonischemicheartfailure AT sgobel increasedcreactiveproteincardiactroponiniandglsareassociatedwithmyocardialinflammationinpatientswithnonischemicheartfailure AT temrich increasedcreactiveproteincardiactroponiniandglsareassociatedwithmyocardialinflammationinpatientswithnonischemicheartfailure AT vhschmitt increasedcreactiveproteincardiactroponiniandglsareassociatedwithmyocardialinflammationinpatientswithnonischemicheartfailure AT ffueting increasedcreactiveproteincardiactroponiniandglsareassociatedwithmyocardialinflammationinpatientswithnonischemicheartfailure AT cklank increasedcreactiveproteincardiactroponiniandglsareassociatedwithmyocardialinflammationinpatientswithnonischemicheartfailure AT fescher increasedcreactiveproteincardiactroponiniandglsareassociatedwithmyocardialinflammationinpatientswithnonischemicheartfailure AT hpschultheiss increasedcreactiveproteincardiactroponiniandglsareassociatedwithmyocardialinflammationinpatientswithnonischemicheartfailure AT tmunzel increasedcreactiveproteincardiactroponiniandglsareassociatedwithmyocardialinflammationinpatientswithnonischemicheartfailure AT kkeller increasedcreactiveproteincardiactroponiniandglsareassociatedwithmyocardialinflammationinpatientswithnonischemicheartfailure AT pwenzel increasedcreactiveproteincardiactroponiniandglsareassociatedwithmyocardialinflammationinpatientswithnonischemicheartfailure
_version_	1718396843317002240

Increased C reactive protein, cardiac troponin I and GLS are associated with myocardial inflammation in patients with non-ischemic heart failure

Ejemplares similares