Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease

Mesenchymal stromal cells (MSCs) have been shown to support multiple myeloma (MM) development. Here, MSCs isolated from the bone marrow of MM patients are shown to have altered DNA methylation patterns and a methyltransferase inhibitor reverts MM-associated bone loss and reduces tumour burden in MM...

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Autores principales:	Antonio Garcia-Gomez, Tianlu Li, Carlos de la Calle-Fabregat, Javier Rodríguez-Ubreva, Laura Ciudad, Francesc Català-Moll, Gerard Godoy-Tena, Montserrat Martín-Sánchez, Laura San-Segundo, Sandra Muntión, Xabier Morales, Carlos Ortiz-de-Solórzano, Julen Oyarzabal, Edurne San José-Enériz, Manel Esteller, Xabier Agirre, Felipe Prosper, Mercedes Garayoa, Esteban Ballestar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/97c0cd9d38aa419d8042bda6761115e0
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spelling	oai:doaj.org-article:97c0cd9d38aa419d8042bda6761115e02021-12-02T14:19:11ZTargeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease10.1038/s41467-020-20715-x2041-1723https://doaj.org/article/97c0cd9d38aa419d8042bda6761115e02021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20715-xhttps://doaj.org/toc/2041-1723Mesenchymal stromal cells (MSCs) have been shown to support multiple myeloma (MM) development. Here, MSCs isolated from the bone marrow of MM patients are shown to have altered DNA methylation patterns and a methyltransferase inhibitor reverts MM-associated bone loss and reduces tumour burden in MM murine models.Antonio Garcia-GomezTianlu LiCarlos de la Calle-FabregatJavier Rodríguez-UbrevaLaura CiudadFrancesc Català-MollGerard Godoy-TenaMontserrat Martín-SánchezLaura San-SegundoSandra MuntiónXabier MoralesCarlos Ortiz-de-SolórzanoJulen OyarzabalEdurne San José-EnérizManel EstellerXabier AgirreFelipe ProsperMercedes GarayoaEsteban BallestarNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Antonio Garcia-Gomez Tianlu Li Carlos de la Calle-Fabregat Javier Rodríguez-Ubreva Laura Ciudad Francesc Català-Moll Gerard Godoy-Tena Montserrat Martín-Sánchez Laura San-Segundo Sandra Muntión Xabier Morales Carlos Ortiz-de-Solórzano Julen Oyarzabal Edurne San José-Enériz Manel Esteller Xabier Agirre Felipe Prosper Mercedes Garayoa Esteban Ballestar Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease
description	Mesenchymal stromal cells (MSCs) have been shown to support multiple myeloma (MM) development. Here, MSCs isolated from the bone marrow of MM patients are shown to have altered DNA methylation patterns and a methyltransferase inhibitor reverts MM-associated bone loss and reduces tumour burden in MM murine models.
format	article
author	Antonio Garcia-Gomez Tianlu Li Carlos de la Calle-Fabregat Javier Rodríguez-Ubreva Laura Ciudad Francesc Català-Moll Gerard Godoy-Tena Montserrat Martín-Sánchez Laura San-Segundo Sandra Muntión Xabier Morales Carlos Ortiz-de-Solórzano Julen Oyarzabal Edurne San José-Enériz Manel Esteller Xabier Agirre Felipe Prosper Mercedes Garayoa Esteban Ballestar
author_facet	Antonio Garcia-Gomez Tianlu Li Carlos de la Calle-Fabregat Javier Rodríguez-Ubreva Laura Ciudad Francesc Català-Moll Gerard Godoy-Tena Montserrat Martín-Sánchez Laura San-Segundo Sandra Muntión Xabier Morales Carlos Ortiz-de-Solórzano Julen Oyarzabal Edurne San José-Enériz Manel Esteller Xabier Agirre Felipe Prosper Mercedes Garayoa Esteban Ballestar
author_sort	Antonio Garcia-Gomez
title	Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease
title_short	Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease
title_full	Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease
title_fullStr	Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease
title_full_unstemmed	Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease
title_sort	targeting aberrant dna methylation in mesenchymal stromal cells as a treatment for myeloma bone disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/97c0cd9d38aa419d8042bda6761115e0
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Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease

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