Amplified spontaneous emission and gain in highly concentrated Rhodamine-doped peptide derivative

Abstract Bioinspired fluorescence, being widely explored for imaging purposes, faces challenges in delivering bright biocompatible sources. While quite a few techniques have been developed to reach this goal, encapsulation of high-quantum yield fluorescent dyes in natural biological forms suggest ac...

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Autores principales:	Andrey Machnev, Daniel Ofer, Ivan Shishkin, Vitali Kozlov, Carlo Diaferia, Antonella Accardo, Giancarlo Morelli, Boris Apter, Alexandra Inberg, Gil Rosenman, Pavel Ginzburg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/97c8aa3cced74f268d71badb31911c2c
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spelling	oai:doaj.org-article:97c8aa3cced74f268d71badb31911c2c2021-12-02T16:38:24ZAmplified spontaneous emission and gain in highly concentrated Rhodamine-doped peptide derivative10.1038/s41598-021-96982-52045-2322https://doaj.org/article/97c8aa3cced74f268d71badb31911c2c2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96982-5https://doaj.org/toc/2045-2322Abstract Bioinspired fluorescence, being widely explored for imaging purposes, faces challenges in delivering bright biocompatible sources. While quite a few techniques have been developed to reach this goal, encapsulation of high-quantum yield fluorescent dyes in natural biological forms suggest achieving superior light-emitting characteristics, approaching amplified spontaneous emission and even lasing. Here we compare gain capabilities of highly concentrated Rhodamine B solutions with a newly synthesized biocompatible peptide derivative hybrid polymer/peptide material, RhoB-PEG1300-F6, which contains the fluorescent covalently bound dye. While concentration quenching effects limit the maximal achievable gain of dissolved Rhodamine B, biocompatible conjugation allows elevating amplification coefficients towards moderately high values. In particular, Rhodamine B, anchored to the peptide derivative material, demonstrates gain of 22–23 cm−1 for a 10−2 M solution, while a pure dye solution possesses 25% smaller values at the same concentration. New biocompatible fluorescent agents pave ways to demonstrate lasing in living organisms and can be further introduced to therapeutic applications, if proper solvents are found.Andrey MachnevDaniel OferIvan ShishkinVitali KozlovCarlo DiaferiaAntonella AccardoGiancarlo MorelliBoris ApterAlexandra InbergGil RosenmanPavel GinzburgNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andrey Machnev Daniel Ofer Ivan Shishkin Vitali Kozlov Carlo Diaferia Antonella Accardo Giancarlo Morelli Boris Apter Alexandra Inberg Gil Rosenman Pavel Ginzburg Amplified spontaneous emission and gain in highly concentrated Rhodamine-doped peptide derivative
description	Abstract Bioinspired fluorescence, being widely explored for imaging purposes, faces challenges in delivering bright biocompatible sources. While quite a few techniques have been developed to reach this goal, encapsulation of high-quantum yield fluorescent dyes in natural biological forms suggest achieving superior light-emitting characteristics, approaching amplified spontaneous emission and even lasing. Here we compare gain capabilities of highly concentrated Rhodamine B solutions with a newly synthesized biocompatible peptide derivative hybrid polymer/peptide material, RhoB-PEG1300-F6, which contains the fluorescent covalently bound dye. While concentration quenching effects limit the maximal achievable gain of dissolved Rhodamine B, biocompatible conjugation allows elevating amplification coefficients towards moderately high values. In particular, Rhodamine B, anchored to the peptide derivative material, demonstrates gain of 22–23 cm−1 for a 10−2 M solution, while a pure dye solution possesses 25% smaller values at the same concentration. New biocompatible fluorescent agents pave ways to demonstrate lasing in living organisms and can be further introduced to therapeutic applications, if proper solvents are found.
format	article
author	Andrey Machnev Daniel Ofer Ivan Shishkin Vitali Kozlov Carlo Diaferia Antonella Accardo Giancarlo Morelli Boris Apter Alexandra Inberg Gil Rosenman Pavel Ginzburg
author_facet	Andrey Machnev Daniel Ofer Ivan Shishkin Vitali Kozlov Carlo Diaferia Antonella Accardo Giancarlo Morelli Boris Apter Alexandra Inberg Gil Rosenman Pavel Ginzburg
author_sort	Andrey Machnev
title	Amplified spontaneous emission and gain in highly concentrated Rhodamine-doped peptide derivative
title_short	Amplified spontaneous emission and gain in highly concentrated Rhodamine-doped peptide derivative
title_full	Amplified spontaneous emission and gain in highly concentrated Rhodamine-doped peptide derivative
title_fullStr	Amplified spontaneous emission and gain in highly concentrated Rhodamine-doped peptide derivative
title_full_unstemmed	Amplified spontaneous emission and gain in highly concentrated Rhodamine-doped peptide derivative
title_sort	amplified spontaneous emission and gain in highly concentrated rhodamine-doped peptide derivative
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/97c8aa3cced74f268d71badb31911c2c
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Amplified spontaneous emission and gain in highly concentrated Rhodamine-doped peptide derivative

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