MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis

Blocking lymphangiogenesis holds great therapeutic potential, however, only few inhibitors are known. Here the authors show that membrane type 1-matrix metalloproteinase suppresses lymphangiogenesis by curbing both LYVE-1-mediated proliferation of lymphatic endothelial cells and production of lympha...

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Auteurs principaux:	Hoi Leong Xavier Wong, Guoxiang Jin, Renhai Cao, Shuo Zhang, Yihai Cao, Zhongjun Zhou
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/97c8aa89a07b44d981cbdc1ecc44d1cd
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id	oai:doaj.org-article:97c8aa89a07b44d981cbdc1ecc44d1cd
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spelling	oai:doaj.org-article:97c8aa89a07b44d981cbdc1ecc44d1cd2021-12-02T17:33:09ZMT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis10.1038/ncomms108242041-1723https://doaj.org/article/97c8aa89a07b44d981cbdc1ecc44d1cd2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10824https://doaj.org/toc/2041-1723Blocking lymphangiogenesis holds great therapeutic potential, however, only few inhibitors are known. Here the authors show that membrane type 1-matrix metalloproteinase suppresses lymphangiogenesis by curbing both LYVE-1-mediated proliferation of lymphatic endothelial cells and production of lymphangiogenic factors by macrophages.Hoi Leong Xavier WongGuoxiang JinRenhai CaoShuo ZhangYihai CaoZhongjun ZhouNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hoi Leong Xavier Wong Guoxiang Jin Renhai Cao Shuo Zhang Yihai Cao Zhongjun Zhou MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis
description	Blocking lymphangiogenesis holds great therapeutic potential, however, only few inhibitors are known. Here the authors show that membrane type 1-matrix metalloproteinase suppresses lymphangiogenesis by curbing both LYVE-1-mediated proliferation of lymphatic endothelial cells and production of lymphangiogenic factors by macrophages.
format	article
author	Hoi Leong Xavier Wong Guoxiang Jin Renhai Cao Shuo Zhang Yihai Cao Zhongjun Zhou
author_facet	Hoi Leong Xavier Wong Guoxiang Jin Renhai Cao Shuo Zhang Yihai Cao Zhongjun Zhou
author_sort	Hoi Leong Xavier Wong
title	MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis
title_short	MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis
title_full	MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis
title_fullStr	MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis
title_full_unstemmed	MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis
title_sort	mt1-mmp sheds lyve-1 on lymphatic endothelial cells and suppresses vegf-c production to inhibit lymphangiogenesis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/97c8aa89a07b44d981cbdc1ecc44d1cd
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_version_	1718380075435425792

MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis

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