Particle Engineering of Chitosan and Kaolin Composite as a Novel Tablet Excipient by Nanoparticles Formation and Co-Processing

Chitosan is not a common excipient for direct compression due to poor flowability and inadequate compressibility. Co-processing of chitosan and kaolin is a challenging method to overcome the limitations of the individual excipients. The purpose of the present study was to develop co-processed chitos...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chonwipa Yarangsee, Phanphen Wattanaarsakit, Jakkapan Sirithunyalug, Phuriwat Leesawat
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	co-processing chitosan kaolin nanoparticles spray drying Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/97ca02cc70404da1871417b055590644
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:97ca02cc70404da1871417b055590644
record_format	dspace
spelling	oai:doaj.org-article:97ca02cc70404da1871417b0555906442021-11-25T18:41:07ZParticle Engineering of Chitosan and Kaolin Composite as a Novel Tablet Excipient by Nanoparticles Formation and Co-Processing10.3390/pharmaceutics131118441999-4923https://doaj.org/article/97ca02cc70404da1871417b0555906442021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1844https://doaj.org/toc/1999-4923Chitosan is not a common excipient for direct compression due to poor flowability and inadequate compressibility. Co-processing of chitosan and kaolin is a challenging method to overcome the limitations of the individual excipients. The purpose of the present study was to develop co-processed chitosan–kaolin by the spray drying technique (rotary atomizer spray dryer) and to characterize the excipient properties. The formation of chitosan nanoparticles was the major factor for desirable tablet hardness. The ratio of chitosan/tripolyphosphate of 10:1 and 20:1 had a significant effect on hardness. The successful development of co-processed chitosan–kaolin as a novel tablet excipient was obtained from a feed formulation composed of chitosan and kaolin at a ratio of 55:45 and the optimum chitosan/tripolyphosphate ratio of 20:1. Co-processing altered the physical properties of co-processed chitosan–kaolin in such a way that it enhanced the flowability and tableting performance compared to the physical mixture.Chonwipa YarangseePhanphen WattanaarsakitJakkapan SirithunyalugPhuriwat LeesawatMDPI AGarticleco-processingchitosankaolinnanoparticlesspray dryingPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1844, p 1844 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	co-processing chitosan kaolin nanoparticles spray drying Pharmacy and materia medica RS1-441
spellingShingle	co-processing chitosan kaolin nanoparticles spray drying Pharmacy and materia medica RS1-441 Chonwipa Yarangsee Phanphen Wattanaarsakit Jakkapan Sirithunyalug Phuriwat Leesawat Particle Engineering of Chitosan and Kaolin Composite as a Novel Tablet Excipient by Nanoparticles Formation and Co-Processing
description	Chitosan is not a common excipient for direct compression due to poor flowability and inadequate compressibility. Co-processing of chitosan and kaolin is a challenging method to overcome the limitations of the individual excipients. The purpose of the present study was to develop co-processed chitosan–kaolin by the spray drying technique (rotary atomizer spray dryer) and to characterize the excipient properties. The formation of chitosan nanoparticles was the major factor for desirable tablet hardness. The ratio of chitosan/tripolyphosphate of 10:1 and 20:1 had a significant effect on hardness. The successful development of co-processed chitosan–kaolin as a novel tablet excipient was obtained from a feed formulation composed of chitosan and kaolin at a ratio of 55:45 and the optimum chitosan/tripolyphosphate ratio of 20:1. Co-processing altered the physical properties of co-processed chitosan–kaolin in such a way that it enhanced the flowability and tableting performance compared to the physical mixture.
format	article
author	Chonwipa Yarangsee Phanphen Wattanaarsakit Jakkapan Sirithunyalug Phuriwat Leesawat
author_facet	Chonwipa Yarangsee Phanphen Wattanaarsakit Jakkapan Sirithunyalug Phuriwat Leesawat
author_sort	Chonwipa Yarangsee
title	Particle Engineering of Chitosan and Kaolin Composite as a Novel Tablet Excipient by Nanoparticles Formation and Co-Processing
title_short	Particle Engineering of Chitosan and Kaolin Composite as a Novel Tablet Excipient by Nanoparticles Formation and Co-Processing
title_full	Particle Engineering of Chitosan and Kaolin Composite as a Novel Tablet Excipient by Nanoparticles Formation and Co-Processing
title_fullStr	Particle Engineering of Chitosan and Kaolin Composite as a Novel Tablet Excipient by Nanoparticles Formation and Co-Processing
title_full_unstemmed	Particle Engineering of Chitosan and Kaolin Composite as a Novel Tablet Excipient by Nanoparticles Formation and Co-Processing
title_sort	particle engineering of chitosan and kaolin composite as a novel tablet excipient by nanoparticles formation and co-processing
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/97ca02cc70404da1871417b055590644
work_keys_str_mv	AT chonwipayarangsee particleengineeringofchitosanandkaolincompositeasanoveltabletexcipientbynanoparticlesformationandcoprocessing AT phanphenwattanaarsakit particleengineeringofchitosanandkaolincompositeasanoveltabletexcipientbynanoparticlesformationandcoprocessing AT jakkapansirithunyalug particleengineeringofchitosanandkaolincompositeasanoveltabletexcipientbynanoparticlesformationandcoprocessing AT phuriwatleesawat particleengineeringofchitosanandkaolincompositeasanoveltabletexcipientbynanoparticlesformationandcoprocessing
_version_	1718410850908241920

Particle Engineering of Chitosan and Kaolin Composite as a Novel Tablet Excipient by Nanoparticles Formation and Co-Processing

Ejemplares similares