Inhibition of serotonergic signaling induces higher consumption of both sucrose solution and toxic baits in carpenter ants

Abstract Biogenic amines play an important role in the regulation of appetitive responses in insects. Among them, serotonin (5-HT) regulates feeding-related processes in numerous insect species. In carpenter ants, 5-HT administration has been shown to depress feeding behavior, thus opening the possi...

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Autores principales:	Roxana Josens, Alina Giacometti, Martin Giurfa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/97ca869617c74ead9a2651341a770f34
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spelling	oai:doaj.org-article:97ca869617c74ead9a2651341a770f342021-12-02T17:18:20ZInhibition of serotonergic signaling induces higher consumption of both sucrose solution and toxic baits in carpenter ants10.1038/s41598-021-98030-82045-2322https://doaj.org/article/97ca869617c74ead9a2651341a770f342021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98030-8https://doaj.org/toc/2045-2322Abstract Biogenic amines play an important role in the regulation of appetitive responses in insects. Among them, serotonin (5-HT) regulates feeding-related processes in numerous insect species. In carpenter ants, 5-HT administration has been shown to depress feeding behavior, thus opening the possibility of using 5-HT modulation in control strategies against those species considered as pest. Here we studied if administration of a 5-HT antagonist, ketanserin, promotes feeding of a sucrose solution and a toxic bait in carpenter ants Camponotus mus. We found that 3 h after a single oral administration of ketanserin, the mass of sucrose solution consumed by carpenter ants increased significantly. A similar effect was found after a chronic administration that lasted 5 days. Yet, ketanserin did neither affect the intake rates nor the activity of the pharyngeal pump that mediates feeding dynamics. In addition, ketanserin promoted the consumption of a toxic bait based on boric acid. Our results thus show that feeding motivation and consumption of both sucrose solution and a toxic bait can be enhanced via prior administration of ketanserin. We discuss the possible mechanisms underlying these effects and conclude that understanding basic physiological and neural principles that underlie feeding motivation allows establishing more efficient control strategies for pest insects.Roxana JosensAlina GiacomettiMartin GiurfaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Roxana Josens Alina Giacometti Martin Giurfa Inhibition of serotonergic signaling induces higher consumption of both sucrose solution and toxic baits in carpenter ants
description	Abstract Biogenic amines play an important role in the regulation of appetitive responses in insects. Among them, serotonin (5-HT) regulates feeding-related processes in numerous insect species. In carpenter ants, 5-HT administration has been shown to depress feeding behavior, thus opening the possibility of using 5-HT modulation in control strategies against those species considered as pest. Here we studied if administration of a 5-HT antagonist, ketanserin, promotes feeding of a sucrose solution and a toxic bait in carpenter ants Camponotus mus. We found that 3 h after a single oral administration of ketanserin, the mass of sucrose solution consumed by carpenter ants increased significantly. A similar effect was found after a chronic administration that lasted 5 days. Yet, ketanserin did neither affect the intake rates nor the activity of the pharyngeal pump that mediates feeding dynamics. In addition, ketanserin promoted the consumption of a toxic bait based on boric acid. Our results thus show that feeding motivation and consumption of both sucrose solution and a toxic bait can be enhanced via prior administration of ketanserin. We discuss the possible mechanisms underlying these effects and conclude that understanding basic physiological and neural principles that underlie feeding motivation allows establishing more efficient control strategies for pest insects.
format	article
author	Roxana Josens Alina Giacometti Martin Giurfa
author_facet	Roxana Josens Alina Giacometti Martin Giurfa
author_sort	Roxana Josens
title	Inhibition of serotonergic signaling induces higher consumption of both sucrose solution and toxic baits in carpenter ants
title_short	Inhibition of serotonergic signaling induces higher consumption of both sucrose solution and toxic baits in carpenter ants
title_full	Inhibition of serotonergic signaling induces higher consumption of both sucrose solution and toxic baits in carpenter ants
title_fullStr	Inhibition of serotonergic signaling induces higher consumption of both sucrose solution and toxic baits in carpenter ants
title_full_unstemmed	Inhibition of serotonergic signaling induces higher consumption of both sucrose solution and toxic baits in carpenter ants
title_sort	inhibition of serotonergic signaling induces higher consumption of both sucrose solution and toxic baits in carpenter ants
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/97ca869617c74ead9a2651341a770f34
work_keys_str_mv	AT roxanajosens inhibitionofserotonergicsignalinginduceshigherconsumptionofbothsucrosesolutionandtoxicbaitsincarpenterants AT alinagiacometti inhibitionofserotonergicsignalinginduceshigherconsumptionofbothsucrosesolutionandtoxicbaitsincarpenterants AT martingiurfa inhibitionofserotonergicsignalinginduceshigherconsumptionofbothsucrosesolutionandtoxicbaitsincarpenterants
_version_	1718381158888112128

Inhibition of serotonergic signaling induces higher consumption of both sucrose solution and toxic baits in carpenter ants

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