Effect of long-term cyclic compression loading on the structural evolution of trabecular bone

Dynamic remodeling of bone tissue is mediated by the synergistic effects of osteoblast-driven bone formation and Osteoclast-dominated bone resorption. However, how bone cells perceive the mechanical stimuli and regulate bone remodeling have not been fully understood. This study aims to evaluate the...

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Autores principales:	Yan Gao, Feixiang Lu, Shouhui Wang, Lianwen Sun, Huijie Leng, Bo Huo
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Bone remodeling Osteoclast Osteoblast Cyclic compression loading Micro-computed tomography Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/97ce4048327c47a9a219f0def52a665f
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spelling	oai:doaj.org-article:97ce4048327c47a9a219f0def52a665f2021-11-26T04:38:55ZEffect of long-term cyclic compression loading on the structural evolution of trabecular bone2590-093510.1016/j.medntd.2021.100099https://doaj.org/article/97ce4048327c47a9a219f0def52a665f2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2590093521000436https://doaj.org/toc/2590-0935Dynamic remodeling of bone tissue is mediated by the synergistic effects of osteoblast-driven bone formation and Osteoclast-dominated bone resorption. However, how bone cells perceive the mechanical stimuli and regulate bone remodeling have not been fully understood. This study aims to evaluate the effect of cyclic compression loading on trabecular microstructure for 42 days and identify the relationship between the evolution of trabecular microstructure and cell distribution. The eighth caudal vertebrae of rats were subjected to long-term cyclic compression loading with different frequencies. The compression displacement is 1 mm. In vivo micro-computed tomography was performed at 0, 14, 28 and 42 days to determine the structural parameters. The bone volume fraction (BV/TV) in the 1 Hz cyclic compression loading group was significantly higher than that in the control and 10 Hz groups, whereas the trabecular separation (Tb.Sp) was significantly lower. The 10 Hz cyclic compression group had the lowest BV/TV and highest Tb.Sp. After 14 days of loading, the BV/TV values of 1 Hz group were 29.62% and 41.6% higher than those of the control and 10 Hz groups, respectively. Conversely, the Tb.Sp of 1 Hz group was approximately 12.33% and 16.52% lower than that of the control and 10 Hz group, respectively. More bone formation and less bone resorption were observed in the 1 Hz group than the control group. In addition, more osteoblasts were attached to the area of bone formation, while more osteoclasts were located in the area of bone resorption. These findings may provide a basis for further understanding mechanical stimulation-regulated bone remodeling.Yan GaoFeixiang LuShouhui WangLianwen SunHuijie LengBo HuoElsevierarticleBone remodelingOsteoclastOsteoblastCyclic compression loadingMicro-computed tomographyMedical technologyR855-855.5ENMedicine in Novel Technology and Devices, Vol 12, Iss , Pp 100099- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bone remodeling Osteoclast Osteoblast Cyclic compression loading Micro-computed tomography Medical technology R855-855.5
spellingShingle	Bone remodeling Osteoclast Osteoblast Cyclic compression loading Micro-computed tomography Medical technology R855-855.5 Yan Gao Feixiang Lu Shouhui Wang Lianwen Sun Huijie Leng Bo Huo Effect of long-term cyclic compression loading on the structural evolution of trabecular bone
description	Dynamic remodeling of bone tissue is mediated by the synergistic effects of osteoblast-driven bone formation and Osteoclast-dominated bone resorption. However, how bone cells perceive the mechanical stimuli and regulate bone remodeling have not been fully understood. This study aims to evaluate the effect of cyclic compression loading on trabecular microstructure for 42 days and identify the relationship between the evolution of trabecular microstructure and cell distribution. The eighth caudal vertebrae of rats were subjected to long-term cyclic compression loading with different frequencies. The compression displacement is 1 mm. In vivo micro-computed tomography was performed at 0, 14, 28 and 42 days to determine the structural parameters. The bone volume fraction (BV/TV) in the 1 Hz cyclic compression loading group was significantly higher than that in the control and 10 Hz groups, whereas the trabecular separation (Tb.Sp) was significantly lower. The 10 Hz cyclic compression group had the lowest BV/TV and highest Tb.Sp. After 14 days of loading, the BV/TV values of 1 Hz group were 29.62% and 41.6% higher than those of the control and 10 Hz groups, respectively. Conversely, the Tb.Sp of 1 Hz group was approximately 12.33% and 16.52% lower than that of the control and 10 Hz group, respectively. More bone formation and less bone resorption were observed in the 1 Hz group than the control group. In addition, more osteoblasts were attached to the area of bone formation, while more osteoclasts were located in the area of bone resorption. These findings may provide a basis for further understanding mechanical stimulation-regulated bone remodeling.
format	article
author	Yan Gao Feixiang Lu Shouhui Wang Lianwen Sun Huijie Leng Bo Huo
author_facet	Yan Gao Feixiang Lu Shouhui Wang Lianwen Sun Huijie Leng Bo Huo
author_sort	Yan Gao
title	Effect of long-term cyclic compression loading on the structural evolution of trabecular bone
title_short	Effect of long-term cyclic compression loading on the structural evolution of trabecular bone
title_full	Effect of long-term cyclic compression loading on the structural evolution of trabecular bone
title_fullStr	Effect of long-term cyclic compression loading on the structural evolution of trabecular bone
title_full_unstemmed	Effect of long-term cyclic compression loading on the structural evolution of trabecular bone
title_sort	effect of long-term cyclic compression loading on the structural evolution of trabecular bone
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/97ce4048327c47a9a219f0def52a665f
work_keys_str_mv	AT yangao effectoflongtermcycliccompressionloadingonthestructuralevolutionoftrabecularbone AT feixianglu effectoflongtermcycliccompressionloadingonthestructuralevolutionoftrabecularbone AT shouhuiwang effectoflongtermcycliccompressionloadingonthestructuralevolutionoftrabecularbone AT lianwensun effectoflongtermcycliccompressionloadingonthestructuralevolutionoftrabecularbone AT huijieleng effectoflongtermcycliccompressionloadingonthestructuralevolutionoftrabecularbone AT bohuo effectoflongtermcycliccompressionloadingonthestructuralevolutionoftrabecularbone
_version_	1718409855964807168

Effect of long-term cyclic compression loading on the structural evolution of trabecular bone

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