Identification of an ATP-controlled allosteric switch that controls actin filament nucleation by Arp2/3 complex

Arp2/3 complex nucleates branched actin filaments, and is inactive in the absense of activators. Here the authors present a model of Arp2/3 autoinhibition, whereby the Arp3 C-terminal tail acts as a structural switch that blocks movement of Arp2 and Arp3 into an activated filament-like conformation.

Guardado en:

Detalles Bibliográficos
Autores principales:	Max Rodnick-Smith, Su-Ling Liu, Connor J. Balzer, Qing Luan, Brad J. Nolen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/97cf8488cd504c99852d793a6ab1a5c9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:97cf8488cd504c99852d793a6ab1a5c9
record_format	dspace
spelling	oai:doaj.org-article:97cf8488cd504c99852d793a6ab1a5c92021-12-02T14:39:31ZIdentification of an ATP-controlled allosteric switch that controls actin filament nucleation by Arp2/3 complex10.1038/ncomms122262041-1723https://doaj.org/article/97cf8488cd504c99852d793a6ab1a5c92016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12226https://doaj.org/toc/2041-1723Arp2/3 complex nucleates branched actin filaments, and is inactive in the absense of activators. Here the authors present a model of Arp2/3 autoinhibition, whereby the Arp3 C-terminal tail acts as a structural switch that blocks movement of Arp2 and Arp3 into an activated filament-like conformation.Max Rodnick-SmithSu-Ling LiuConnor J. BalzerQing LuanBrad J. NolenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Max Rodnick-Smith Su-Ling Liu Connor J. Balzer Qing Luan Brad J. Nolen Identification of an ATP-controlled allosteric switch that controls actin filament nucleation by Arp2/3 complex
description	Arp2/3 complex nucleates branched actin filaments, and is inactive in the absense of activators. Here the authors present a model of Arp2/3 autoinhibition, whereby the Arp3 C-terminal tail acts as a structural switch that blocks movement of Arp2 and Arp3 into an activated filament-like conformation.
format	article
author	Max Rodnick-Smith Su-Ling Liu Connor J. Balzer Qing Luan Brad J. Nolen
author_facet	Max Rodnick-Smith Su-Ling Liu Connor J. Balzer Qing Luan Brad J. Nolen
author_sort	Max Rodnick-Smith
title	Identification of an ATP-controlled allosteric switch that controls actin filament nucleation by Arp2/3 complex
title_short	Identification of an ATP-controlled allosteric switch that controls actin filament nucleation by Arp2/3 complex
title_full	Identification of an ATP-controlled allosteric switch that controls actin filament nucleation by Arp2/3 complex
title_fullStr	Identification of an ATP-controlled allosteric switch that controls actin filament nucleation by Arp2/3 complex
title_full_unstemmed	Identification of an ATP-controlled allosteric switch that controls actin filament nucleation by Arp2/3 complex
title_sort	identification of an atp-controlled allosteric switch that controls actin filament nucleation by arp2/3 complex
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/97cf8488cd504c99852d793a6ab1a5c9
work_keys_str_mv	AT maxrodnicksmith identificationofanatpcontrolledallostericswitchthatcontrolsactinfilamentnucleationbyarp23complex AT sulingliu identificationofanatpcontrolledallostericswitchthatcontrolsactinfilamentnucleationbyarp23complex AT connorjbalzer identificationofanatpcontrolledallostericswitchthatcontrolsactinfilamentnucleationbyarp23complex AT qingluan identificationofanatpcontrolledallostericswitchthatcontrolsactinfilamentnucleationbyarp23complex AT bradjnolen identificationofanatpcontrolledallostericswitchthatcontrolsactinfilamentnucleationbyarp23complex
_version_	1718390605705379840

Identification of an ATP-controlled allosteric switch that controls actin filament nucleation by Arp2/3 complex

Ejemplares similares