Identification of an ATP-controlled allosteric switch that controls actin filament nucleation by Arp2/3 complex
Arp2/3 complex nucleates branched actin filaments, and is inactive in the absense of activators. Here the authors present a model of Arp2/3 autoinhibition, whereby the Arp3 C-terminal tail acts as a structural switch that blocks movement of Arp2 and Arp3 into an activated filament-like conformation.
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| Auteurs principaux: | , , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2016
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| Sujets: | |
| Accès en ligne: | https://doaj.org/article/97cf8488cd504c99852d793a6ab1a5c9 |
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