Differential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time: a dual birthdating analysis.

Adult hippocampal neurogenesis (AHN) augments after environmental enrichment (EE) and it has been related to some of the anxiolytic, antidepressant and neuroprotective effects of EE. Indeed, it has been suggested that EE specifically modulates hippocampal neurogenic cell populations over the course...

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Autores principales:	María Llorens-Martín, Gonzalo S Tejeda, José L Trejo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/97d39f68f60943fb9fe0dcd6b8cf54b7
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spelling	oai:doaj.org-article:97d39f68f60943fb9fe0dcd6b8cf54b72021-11-18T06:36:03ZDifferential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time: a dual birthdating analysis.1932-620310.1371/journal.pone.0012188https://doaj.org/article/97d39f68f60943fb9fe0dcd6b8cf54b72010-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20808440/?tool=EBIhttps://doaj.org/toc/1932-6203Adult hippocampal neurogenesis (AHN) augments after environmental enrichment (EE) and it has been related to some of the anxiolytic, antidepressant and neuroprotective effects of EE. Indeed, it has been suggested that EE specifically modulates hippocampal neurogenic cell populations over the course of time. Here we have used dual-birthdating to study two subpopulations of newborn neuron in mice (Mus musculus): those born at the beginning and at the end of enrichment. In this way, we demonstrate that while short-term cell survival is upregulated after an initial 1 week period of enrichment in 2 month old female mice, after long-term enrichment (2 months) neither cell proliferation nor the survival of the younger newly born cell populations are distinguishable from that observed in non-enriched control mice. In addition, we show that the survival of older newborn neurons alone (i.e. those born at the beginning of the enrichment) is higher than in controls, due to the significantly lower levels of cell death. Indeed, these parameters are rapidly adjusted to the sudden cessation of the EE conditions. These findings suggest both an early selective, long-lasting effect of EE on the neurons born in the initial stages of enrichment, and a quick response when the environment again becomes impoverished. Therefore, EE induces differential effects on distinct subpopulations of newborn neurons depending on the age of the immature cells and on the duration of the EE itself. The interaction of these two parameters constitutes a new, specific regulation of these neurogenic populations that might account for the long-term enrichment's behavioral effects.María Llorens-MartínGonzalo S TejedaJosé L TrejoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 8, p e12188 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q María Llorens-Martín Gonzalo S Tejeda José L Trejo Differential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time: a dual birthdating analysis.
description	Adult hippocampal neurogenesis (AHN) augments after environmental enrichment (EE) and it has been related to some of the anxiolytic, antidepressant and neuroprotective effects of EE. Indeed, it has been suggested that EE specifically modulates hippocampal neurogenic cell populations over the course of time. Here we have used dual-birthdating to study two subpopulations of newborn neuron in mice (Mus musculus): those born at the beginning and at the end of enrichment. In this way, we demonstrate that while short-term cell survival is upregulated after an initial 1 week period of enrichment in 2 month old female mice, after long-term enrichment (2 months) neither cell proliferation nor the survival of the younger newly born cell populations are distinguishable from that observed in non-enriched control mice. In addition, we show that the survival of older newborn neurons alone (i.e. those born at the beginning of the enrichment) is higher than in controls, due to the significantly lower levels of cell death. Indeed, these parameters are rapidly adjusted to the sudden cessation of the EE conditions. These findings suggest both an early selective, long-lasting effect of EE on the neurons born in the initial stages of enrichment, and a quick response when the environment again becomes impoverished. Therefore, EE induces differential effects on distinct subpopulations of newborn neurons depending on the age of the immature cells and on the duration of the EE itself. The interaction of these two parameters constitutes a new, specific regulation of these neurogenic populations that might account for the long-term enrichment's behavioral effects.
format	article
author	María Llorens-Martín Gonzalo S Tejeda José L Trejo
author_facet	María Llorens-Martín Gonzalo S Tejeda José L Trejo
author_sort	María Llorens-Martín
title	Differential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time: a dual birthdating analysis.
title_short	Differential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time: a dual birthdating analysis.
title_full	Differential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time: a dual birthdating analysis.
title_fullStr	Differential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time: a dual birthdating analysis.
title_full_unstemmed	Differential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time: a dual birthdating analysis.
title_sort	differential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time: a dual birthdating analysis.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/97d39f68f60943fb9fe0dcd6b8cf54b7
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Differential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time: a dual birthdating analysis.

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