Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor

G protein-coupled receptors (GPCRs) activate and dissociate the G protein heterotrimer into Gα-GTP and Gβγ dimer, which facilitate distinct signalling events. Here authors develop a nanobody, Nb5 that modulates Gβγ-mediated signaling without affecting GTP-bound Gαq and Gαs-mediated signaling events....

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Autores principales:	Sahil Gulati, Hui Jin, Ikuo Masuho, Tivadar Orban, Yuan Cai, Els Pardon, Kirill A. Martemyanov, Philip D. Kiser, Phoebe L. Stewart, Christopher P. Ford, Jan Steyaert, Krzysztof Palczewski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/97d5df502176477f968bd4bc5a4ab8fb
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spelling	oai:doaj.org-article:97d5df502176477f968bd4bc5a4ab8fb2021-12-02T16:50:07ZTargeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor10.1038/s41467-018-04432-02041-1723https://doaj.org/article/97d5df502176477f968bd4bc5a4ab8fb2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04432-0https://doaj.org/toc/2041-1723G protein-coupled receptors (GPCRs) activate and dissociate the G protein heterotrimer into Gα-GTP and Gβγ dimer, which facilitate distinct signalling events. Here authors develop a nanobody, Nb5 that modulates Gβγ-mediated signaling without affecting GTP-bound Gαq and Gαs-mediated signaling events.Sahil GulatiHui JinIkuo MasuhoTivadar OrbanYuan CaiEls PardonKirill A. MartemyanovPhilip D. KiserPhoebe L. StewartChristopher P. FordJan SteyaertKrzysztof PalczewskiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sahil Gulati Hui Jin Ikuo Masuho Tivadar Orban Yuan Cai Els Pardon Kirill A. Martemyanov Philip D. Kiser Phoebe L. Stewart Christopher P. Ford Jan Steyaert Krzysztof Palczewski Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor
description	G protein-coupled receptors (GPCRs) activate and dissociate the G protein heterotrimer into Gα-GTP and Gβγ dimer, which facilitate distinct signalling events. Here authors develop a nanobody, Nb5 that modulates Gβγ-mediated signaling without affecting GTP-bound Gαq and Gαs-mediated signaling events.
format	article
author	Sahil Gulati Hui Jin Ikuo Masuho Tivadar Orban Yuan Cai Els Pardon Kirill A. Martemyanov Philip D. Kiser Phoebe L. Stewart Christopher P. Ford Jan Steyaert Krzysztof Palczewski
author_facet	Sahil Gulati Hui Jin Ikuo Masuho Tivadar Orban Yuan Cai Els Pardon Kirill A. Martemyanov Philip D. Kiser Phoebe L. Stewart Christopher P. Ford Jan Steyaert Krzysztof Palczewski
author_sort	Sahil Gulati
title	Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor
title_short	Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor
title_full	Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor
title_fullStr	Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor
title_full_unstemmed	Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor
title_sort	targeting g protein-coupled receptor signaling at the g protein level with a selective nanobody inhibitor
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/97d5df502176477f968bd4bc5a4ab8fb
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Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor

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