Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor
G protein-coupled receptors (GPCRs) activate and dissociate the G protein heterotrimer into Gα-GTP and Gβγ dimer, which facilitate distinct signalling events. Here authors develop a nanobody, Nb5 that modulates Gβγ-mediated signaling without affecting GTP-bound Gαq and Gαs-mediated signaling events....
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Autores principales: | Sahil Gulati, Hui Jin, Ikuo Masuho, Tivadar Orban, Yuan Cai, Els Pardon, Kirill A. Martemyanov, Philip D. Kiser, Phoebe L. Stewart, Christopher P. Ford, Jan Steyaert, Krzysztof Palczewski |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
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Materias: | |
Acceso en línea: | https://doaj.org/article/97d5df502176477f968bd4bc5a4ab8fb |
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