Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor

Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor

G protein-coupled receptors (GPCRs) activate and dissociate the G protein heterotrimer into Gα-GTP and Gβγ dimer, which facilitate distinct signalling events. Here authors develop a nanobody, Nb5 that modulates Gβγ-mediated signaling without affecting GTP-bound Gαq and Gαs-mediated signaling events....

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Bibliographic Details
Main Authors: Sahil Gulati, Hui Jin, Ikuo Masuho, Tivadar Orban, Yuan Cai, Els Pardon, Kirill A. Martemyanov, Philip D. Kiser, Phoebe L. Stewart, Christopher P. Ford, Jan Steyaert, Krzysztof Palczewski
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
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Online Access:https://doaj.org/article/97d5df502176477f968bd4bc5a4ab8fb
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https://doaj.org/article/97d5df502176477f968bd4bc5a4ab8fb

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