CASZ1 induces skeletal muscle and rhabdomyosarcoma differentiation through a feed-forward loop with MYOD and MYOG

Embryonal rhabdomyosarcoma (ERMS) is a childhood cancer with impaired myogenic differentiation despite the presence of myogenic transcription factors. Here, the authors show that CASZ1 directly regulates these myogenic factors and the loss of CASZ1 is due to RAS-MEK signaling in ERMS.

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Autores principales:	Zhihui Liu, Xiyuan Zhang, Haiyan Lei, Norris Lam, Sakereh Carter, Oliver Yockey, Max Xu, Arnulfo Mendoza, Edjay R. Hernandez, Jun S. Wei, Javed Khan, Marielle E. Yohe, Jack F. Shern, Carol J. Thiele
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/97d6c3168b084c6fbf5af342e06696ec
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spelling	oai:doaj.org-article:97d6c3168b084c6fbf5af342e06696ec2021-12-02T14:40:53ZCASZ1 induces skeletal muscle and rhabdomyosarcoma differentiation through a feed-forward loop with MYOD and MYOG10.1038/s41467-020-14684-42041-1723https://doaj.org/article/97d6c3168b084c6fbf5af342e06696ec2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14684-4https://doaj.org/toc/2041-1723Embryonal rhabdomyosarcoma (ERMS) is a childhood cancer with impaired myogenic differentiation despite the presence of myogenic transcription factors. Here, the authors show that CASZ1 directly regulates these myogenic factors and the loss of CASZ1 is due to RAS-MEK signaling in ERMS.Zhihui LiuXiyuan ZhangHaiyan LeiNorris LamSakereh CarterOliver YockeyMax XuArnulfo MendozaEdjay R. HernandezJun S. WeiJaved KhanMarielle E. YoheJack F. ShernCarol J. ThieleNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhihui Liu Xiyuan Zhang Haiyan Lei Norris Lam Sakereh Carter Oliver Yockey Max Xu Arnulfo Mendoza Edjay R. Hernandez Jun S. Wei Javed Khan Marielle E. Yohe Jack F. Shern Carol J. Thiele CASZ1 induces skeletal muscle and rhabdomyosarcoma differentiation through a feed-forward loop with MYOD and MYOG
description	Embryonal rhabdomyosarcoma (ERMS) is a childhood cancer with impaired myogenic differentiation despite the presence of myogenic transcription factors. Here, the authors show that CASZ1 directly regulates these myogenic factors and the loss of CASZ1 is due to RAS-MEK signaling in ERMS.
format	article
author	Zhihui Liu Xiyuan Zhang Haiyan Lei Norris Lam Sakereh Carter Oliver Yockey Max Xu Arnulfo Mendoza Edjay R. Hernandez Jun S. Wei Javed Khan Marielle E. Yohe Jack F. Shern Carol J. Thiele
author_facet	Zhihui Liu Xiyuan Zhang Haiyan Lei Norris Lam Sakereh Carter Oliver Yockey Max Xu Arnulfo Mendoza Edjay R. Hernandez Jun S. Wei Javed Khan Marielle E. Yohe Jack F. Shern Carol J. Thiele
author_sort	Zhihui Liu
title	CASZ1 induces skeletal muscle and rhabdomyosarcoma differentiation through a feed-forward loop with MYOD and MYOG
title_short	CASZ1 induces skeletal muscle and rhabdomyosarcoma differentiation through a feed-forward loop with MYOD and MYOG
title_full	CASZ1 induces skeletal muscle and rhabdomyosarcoma differentiation through a feed-forward loop with MYOD and MYOG
title_fullStr	CASZ1 induces skeletal muscle and rhabdomyosarcoma differentiation through a feed-forward loop with MYOD and MYOG
title_full_unstemmed	CASZ1 induces skeletal muscle and rhabdomyosarcoma differentiation through a feed-forward loop with MYOD and MYOG
title_sort	casz1 induces skeletal muscle and rhabdomyosarcoma differentiation through a feed-forward loop with myod and myog
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/97d6c3168b084c6fbf5af342e06696ec
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CASZ1 induces skeletal muscle and rhabdomyosarcoma differentiation through a feed-forward loop with MYOD and MYOG

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