B Cell Signatures Distinguish Cutaneous Lupus Erythematosus Subtypes and the Presence of Systemic Disease Activity

Cutaneous lupus erythematosus (CLE) is a chronic inflammatory skin disease characterized by a diverse cadre of clinical presentations. CLE commonly occurs in patients with systemic lupus erythematosus (SLE), and CLE can also develop in the absence of systemic disease. Although CLE is a complex and h...

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Autores principales:	Lisa Abernathy-Close, Stephanie Lazar, Jasmine Stannard, Lam C. Tsoi, Sean Eddy, Syed M. Rizvi, Christine M. Yee, Emily M. Myers, Rajaie Namas, Lori Lowe, Tamra J. Reed, Fei Wen, Johann E. Gudjonsson, J. Michelle Kahlenberg, Celine C. Berthier
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	lupus discoid B cells transcriptomic cutaneous lupus autoantibodies Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/97d8f84aafb64fb2aa44b9d028af7575
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spelling	oai:doaj.org-article:97d8f84aafb64fb2aa44b9d028af75752021-11-19T07:52:34ZB Cell Signatures Distinguish Cutaneous Lupus Erythematosus Subtypes and the Presence of Systemic Disease Activity1664-322410.3389/fimmu.2021.775353https://doaj.org/article/97d8f84aafb64fb2aa44b9d028af75752021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.775353/fullhttps://doaj.org/toc/1664-3224Cutaneous lupus erythematosus (CLE) is a chronic inflammatory skin disease characterized by a diverse cadre of clinical presentations. CLE commonly occurs in patients with systemic lupus erythematosus (SLE), and CLE can also develop in the absence of systemic disease. Although CLE is a complex and heterogeneous disease, several studies have identified common signaling pathways, including those of type I interferons (IFNs), that play a key role in driving cutaneous inflammation across all CLE subsets. However, discriminating factors that drive different phenotypes of skin lesions remain to be determined. Thus, we sought to understand the skin-associated cellular and transcriptional differences in CLE subsets and how the different types of cutaneous inflammation relate to the presence of systemic lupus disease. In this study, we utilized two distinct cohorts comprising a total of 150 CLE lesional biopsies to compare discoid lupus erythematosus (DLE), subacute cutaneous lupus erythematosus (SCLE), and acute cutaneous lupus erythematosus (ACLE) in patients with and without associated SLE. Using an unbiased approach, we demonstrated a CLE subtype-dependent gradient of B cell enrichment in the skin, with DLE lesions harboring a more dominant skin B cell transcriptional signature and enrichment of B cells on immunostaining compared to ACLE and SCLE. Additionally, we observed a significant increase in B cell signatures in the lesional skin from patients with isolated CLE compared with similar lesions from patients with systemic lupus. This trend was driven primarily by differences in the DLE subgroup. Our work thus shows that skin-associated B cell responses distinguish CLE subtypes in patients with and without associated SLE, suggesting that B cell function in skin may be an important link between cutaneous lupus and systemic disease activity.Lisa Abernathy-CloseStephanie LazarJasmine StannardJasmine StannardLam C. TsoiLam C. TsoiLam C. TsoiSean EddySyed M. RizviChristine M. YeeEmily M. MyersRajaie NamasLori LoweLori LoweTamra J. ReedFei WenJohann E. GudjonssonJ. Michelle KahlenbergCeline C. BerthierFrontiers Media S.A.articlelupusdiscoidB cellstranscriptomiccutaneous lupusautoantibodiesImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lupus discoid B cells transcriptomic cutaneous lupus autoantibodies Immunologic diseases. Allergy RC581-607
spellingShingle	lupus discoid B cells transcriptomic cutaneous lupus autoantibodies Immunologic diseases. Allergy RC581-607 Lisa Abernathy-Close Stephanie Lazar Jasmine Stannard Jasmine Stannard Lam C. Tsoi Lam C. Tsoi Lam C. Tsoi Sean Eddy Syed M. Rizvi Christine M. Yee Emily M. Myers Rajaie Namas Lori Lowe Lori Lowe Tamra J. Reed Fei Wen Johann E. Gudjonsson J. Michelle Kahlenberg Celine C. Berthier B Cell Signatures Distinguish Cutaneous Lupus Erythematosus Subtypes and the Presence of Systemic Disease Activity
description	Cutaneous lupus erythematosus (CLE) is a chronic inflammatory skin disease characterized by a diverse cadre of clinical presentations. CLE commonly occurs in patients with systemic lupus erythematosus (SLE), and CLE can also develop in the absence of systemic disease. Although CLE is a complex and heterogeneous disease, several studies have identified common signaling pathways, including those of type I interferons (IFNs), that play a key role in driving cutaneous inflammation across all CLE subsets. However, discriminating factors that drive different phenotypes of skin lesions remain to be determined. Thus, we sought to understand the skin-associated cellular and transcriptional differences in CLE subsets and how the different types of cutaneous inflammation relate to the presence of systemic lupus disease. In this study, we utilized two distinct cohorts comprising a total of 150 CLE lesional biopsies to compare discoid lupus erythematosus (DLE), subacute cutaneous lupus erythematosus (SCLE), and acute cutaneous lupus erythematosus (ACLE) in patients with and without associated SLE. Using an unbiased approach, we demonstrated a CLE subtype-dependent gradient of B cell enrichment in the skin, with DLE lesions harboring a more dominant skin B cell transcriptional signature and enrichment of B cells on immunostaining compared to ACLE and SCLE. Additionally, we observed a significant increase in B cell signatures in the lesional skin from patients with isolated CLE compared with similar lesions from patients with systemic lupus. This trend was driven primarily by differences in the DLE subgroup. Our work thus shows that skin-associated B cell responses distinguish CLE subtypes in patients with and without associated SLE, suggesting that B cell function in skin may be an important link between cutaneous lupus and systemic disease activity.
format	article
author	Lisa Abernathy-Close Stephanie Lazar Jasmine Stannard Jasmine Stannard Lam C. Tsoi Lam C. Tsoi Lam C. Tsoi Sean Eddy Syed M. Rizvi Christine M. Yee Emily M. Myers Rajaie Namas Lori Lowe Lori Lowe Tamra J. Reed Fei Wen Johann E. Gudjonsson J. Michelle Kahlenberg Celine C. Berthier
author_facet	Lisa Abernathy-Close Stephanie Lazar Jasmine Stannard Jasmine Stannard Lam C. Tsoi Lam C. Tsoi Lam C. Tsoi Sean Eddy Syed M. Rizvi Christine M. Yee Emily M. Myers Rajaie Namas Lori Lowe Lori Lowe Tamra J. Reed Fei Wen Johann E. Gudjonsson J. Michelle Kahlenberg Celine C. Berthier
author_sort	Lisa Abernathy-Close
title	B Cell Signatures Distinguish Cutaneous Lupus Erythematosus Subtypes and the Presence of Systemic Disease Activity
title_short	B Cell Signatures Distinguish Cutaneous Lupus Erythematosus Subtypes and the Presence of Systemic Disease Activity
title_full	B Cell Signatures Distinguish Cutaneous Lupus Erythematosus Subtypes and the Presence of Systemic Disease Activity
title_fullStr	B Cell Signatures Distinguish Cutaneous Lupus Erythematosus Subtypes and the Presence of Systemic Disease Activity
title_full_unstemmed	B Cell Signatures Distinguish Cutaneous Lupus Erythematosus Subtypes and the Presence of Systemic Disease Activity
title_sort	b cell signatures distinguish cutaneous lupus erythematosus subtypes and the presence of systemic disease activity
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/97d8f84aafb64fb2aa44b9d028af7575
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B Cell Signatures Distinguish Cutaneous Lupus Erythematosus Subtypes and the Presence of Systemic Disease Activity

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