Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury

Oligodendrocyte progenitor cell (OPC) proliferation is crucial for regeneration after hypoxic lesions in mice, a model of diffuse white matter injury of premature infants. Here, the authors show that the histone deacetylase Sirt1 is a Cdk2-dependent mediator of OPC proliferation and OPC response to...

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Autores principales:	Beata Jablonska, Marcin Gierdalski, Li-Jin Chew, Teresa Hawley, Mackenzie Catron, Arturo Lichauco, Juan Cabrera-Luque, Tracy Yuen, David Rowitch, Vittorio Gallo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/97db07f9d9a64b86bd58146875a5c0da
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spelling	oai:doaj.org-article:97db07f9d9a64b86bd58146875a5c0da2021-12-02T17:33:07ZSirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury10.1038/ncomms138662041-1723https://doaj.org/article/97db07f9d9a64b86bd58146875a5c0da2016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13866https://doaj.org/toc/2041-1723Oligodendrocyte progenitor cell (OPC) proliferation is crucial for regeneration after hypoxic lesions in mice, a model of diffuse white matter injury of premature infants. Here, the authors show that the histone deacetylase Sirt1 is a Cdk2-dependent mediator of OPC proliferation and OPC response to hypoxia.Beata JablonskaMarcin GierdalskiLi-Jin ChewTeresa HawleyMackenzie CatronArturo LichaucoJuan Cabrera-LuqueTracy YuenDavid RowitchVittorio GalloNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Beata Jablonska Marcin Gierdalski Li-Jin Chew Teresa Hawley Mackenzie Catron Arturo Lichauco Juan Cabrera-Luque Tracy Yuen David Rowitch Vittorio Gallo Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury
description	Oligodendrocyte progenitor cell (OPC) proliferation is crucial for regeneration after hypoxic lesions in mice, a model of diffuse white matter injury of premature infants. Here, the authors show that the histone deacetylase Sirt1 is a Cdk2-dependent mediator of OPC proliferation and OPC response to hypoxia.
format	article
author	Beata Jablonska Marcin Gierdalski Li-Jin Chew Teresa Hawley Mackenzie Catron Arturo Lichauco Juan Cabrera-Luque Tracy Yuen David Rowitch Vittorio Gallo
author_facet	Beata Jablonska Marcin Gierdalski Li-Jin Chew Teresa Hawley Mackenzie Catron Arturo Lichauco Juan Cabrera-Luque Tracy Yuen David Rowitch Vittorio Gallo
author_sort	Beata Jablonska
title	Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury
title_short	Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury
title_full	Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury
title_fullStr	Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury
title_full_unstemmed	Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury
title_sort	sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/97db07f9d9a64b86bd58146875a5c0da
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Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury

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