Effect of Chemotherapy on Overall Survival in Contemporary Metastatic Prostate Cancer Patients

IntroductionRandomized clinical trials demonstrated improved overall survival in chemotherapy exposed metastatic prostate cancer patients. However, real-world data validating this effect with large scale epidemiological data sets are scarce and might not agree with trials. We tested this hypothesis....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Benedikt Hoeh, Christoph Würnschimmel, Rocco S. Flammia, Benedikt Horlemann, Gabriele Sorce, Francesco Chierigo, Zhe Tian, Fred Saad, Markus Graefen, Michele Gallucci, Alberto Briganti, Carlo Terrone, Shahrokh F. Shariat, Derya Tilki, Luis A. Kluth, Philipp Mandel, Felix K. H. Chun, Pierre I. Karakiewicz
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	chemotherapy overall survival metastatic prostate cancer SEER contemporary Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/97dcbf84b04d492499e50361ac8d0cb7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:97dcbf84b04d492499e50361ac8d0cb7
record_format	dspace
spelling	oai:doaj.org-article:97dcbf84b04d492499e50361ac8d0cb72021-11-30T11:48:54ZEffect of Chemotherapy on Overall Survival in Contemporary Metastatic Prostate Cancer Patients2234-943X10.3389/fonc.2021.778858https://doaj.org/article/97dcbf84b04d492499e50361ac8d0cb72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.778858/fullhttps://doaj.org/toc/2234-943XIntroductionRandomized clinical trials demonstrated improved overall survival in chemotherapy exposed metastatic prostate cancer patients. However, real-world data validating this effect with large scale epidemiological data sets are scarce and might not agree with trials. We tested this hypothesis.Materials and MethodsWe identified de novo metastatic prostate cancer patients within the Surveillance, Epidemiology, and End Results (SEER) database (2014-2015). Kaplan-Meier plots and Cox regression models tested for overall survival differences between chemotherapy-exposed patients vs chemotherapy-naïve patients. All analyses were repeated in propensity-score matched cohorts. Additionally, landmark analyses were applied to account for potential immortal time bias.ResultsOverall, 4295 de novo metastatic prostate cancer patients were identified. Of those, 905 (21.1%) patients received chemotherapy vs 3390 (78.9%) did not. Median overall survival was not reached at 30 months follow-up. Chemotherapy-exposed patients exhibited significantly better overall survival (61.6 vs 54.3%, multivariable HR:0.82, CI: 0.72-0.96, p=0.01) at 30 months compared to their chemotherapy-naïve counterparts. These findings were confirmed in propensity score matched analyses (multivariable HR: 0.77, CI:0.66-0.90, p<0.001). Results remained unchanged after landmark analyses were applied in propensity score matched population.ConclusionsIn this contemporary real-world population-based cohort, chemotherapy for metastatic prostate cancer patients was associated with better overall survival. However, the magnitude of overall survival benefit was not comparable to phase 3 trials.Benedikt HoehBenedikt HoehChristoph WürnschimmelChristoph WürnschimmelRocco S. FlammiaRocco S. FlammiaBenedikt HorlemannGabriele SorceGabriele SorceFrancesco ChierigoFrancesco ChierigoZhe TianFred SaadMarkus GraefenMichele GallucciAlberto BrigantiCarlo TerroneShahrokh F. ShariatShahrokh F. ShariatShahrokh F. ShariatShahrokh F. ShariatShahrokh F. ShariatShahrokh F. ShariatDerya TilkiDerya TilkiLuis A. KluthPhilipp MandelFelix K. H. ChunPierre I. KarakiewiczFrontiers Media S.A.articlechemotherapyoverall survivalmetastatic prostate cancerSEERcontemporaryNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chemotherapy overall survival metastatic prostate cancer SEER contemporary Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	chemotherapy overall survival metastatic prostate cancer SEER contemporary Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Benedikt Hoeh Benedikt Hoeh Christoph Würnschimmel Christoph Würnschimmel Rocco S. Flammia Rocco S. Flammia Benedikt Horlemann Gabriele Sorce Gabriele Sorce Francesco Chierigo Francesco Chierigo Zhe Tian Fred Saad Markus Graefen Michele Gallucci Alberto Briganti Carlo Terrone Shahrokh F. Shariat Shahrokh F. Shariat Shahrokh F. Shariat Shahrokh F. Shariat Shahrokh F. Shariat Shahrokh F. Shariat Derya Tilki Derya Tilki Luis A. Kluth Philipp Mandel Felix K. H. Chun Pierre I. Karakiewicz Effect of Chemotherapy on Overall Survival in Contemporary Metastatic Prostate Cancer Patients
description	IntroductionRandomized clinical trials demonstrated improved overall survival in chemotherapy exposed metastatic prostate cancer patients. However, real-world data validating this effect with large scale epidemiological data sets are scarce and might not agree with trials. We tested this hypothesis.Materials and MethodsWe identified de novo metastatic prostate cancer patients within the Surveillance, Epidemiology, and End Results (SEER) database (2014-2015). Kaplan-Meier plots and Cox regression models tested for overall survival differences between chemotherapy-exposed patients vs chemotherapy-naïve patients. All analyses were repeated in propensity-score matched cohorts. Additionally, landmark analyses were applied to account for potential immortal time bias.ResultsOverall, 4295 de novo metastatic prostate cancer patients were identified. Of those, 905 (21.1%) patients received chemotherapy vs 3390 (78.9%) did not. Median overall survival was not reached at 30 months follow-up. Chemotherapy-exposed patients exhibited significantly better overall survival (61.6 vs 54.3%, multivariable HR:0.82, CI: 0.72-0.96, p=0.01) at 30 months compared to their chemotherapy-naïve counterparts. These findings were confirmed in propensity score matched analyses (multivariable HR: 0.77, CI:0.66-0.90, p<0.001). Results remained unchanged after landmark analyses were applied in propensity score matched population.ConclusionsIn this contemporary real-world population-based cohort, chemotherapy for metastatic prostate cancer patients was associated with better overall survival. However, the magnitude of overall survival benefit was not comparable to phase 3 trials.
format	article
author	Benedikt Hoeh Benedikt Hoeh Christoph Würnschimmel Christoph Würnschimmel Rocco S. Flammia Rocco S. Flammia Benedikt Horlemann Gabriele Sorce Gabriele Sorce Francesco Chierigo Francesco Chierigo Zhe Tian Fred Saad Markus Graefen Michele Gallucci Alberto Briganti Carlo Terrone Shahrokh F. Shariat Shahrokh F. Shariat Shahrokh F. Shariat Shahrokh F. Shariat Shahrokh F. Shariat Shahrokh F. Shariat Derya Tilki Derya Tilki Luis A. Kluth Philipp Mandel Felix K. H. Chun Pierre I. Karakiewicz
author_facet	Benedikt Hoeh Benedikt Hoeh Christoph Würnschimmel Christoph Würnschimmel Rocco S. Flammia Rocco S. Flammia Benedikt Horlemann Gabriele Sorce Gabriele Sorce Francesco Chierigo Francesco Chierigo Zhe Tian Fred Saad Markus Graefen Michele Gallucci Alberto Briganti Carlo Terrone Shahrokh F. Shariat Shahrokh F. Shariat Shahrokh F. Shariat Shahrokh F. Shariat Shahrokh F. Shariat Shahrokh F. Shariat Derya Tilki Derya Tilki Luis A. Kluth Philipp Mandel Felix K. H. Chun Pierre I. Karakiewicz
author_sort	Benedikt Hoeh
title	Effect of Chemotherapy on Overall Survival in Contemporary Metastatic Prostate Cancer Patients
title_short	Effect of Chemotherapy on Overall Survival in Contemporary Metastatic Prostate Cancer Patients
title_full	Effect of Chemotherapy on Overall Survival in Contemporary Metastatic Prostate Cancer Patients
title_fullStr	Effect of Chemotherapy on Overall Survival in Contemporary Metastatic Prostate Cancer Patients
title_full_unstemmed	Effect of Chemotherapy on Overall Survival in Contemporary Metastatic Prostate Cancer Patients
title_sort	effect of chemotherapy on overall survival in contemporary metastatic prostate cancer patients
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/97dcbf84b04d492499e50361ac8d0cb7
work_keys_str_mv	AT benedikthoeh effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT benedikthoeh effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT christophwurnschimmel effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT christophwurnschimmel effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT roccosflammia effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT roccosflammia effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT benedikthorlemann effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT gabrielesorce effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT gabrielesorce effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT francescochierigo effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT francescochierigo effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT zhetian effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT fredsaad effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT markusgraefen effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT michelegallucci effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT albertobriganti effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT carloterrone effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT shahrokhfshariat effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT shahrokhfshariat effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT shahrokhfshariat effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT shahrokhfshariat effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT shahrokhfshariat effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT shahrokhfshariat effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT deryatilki effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT deryatilki effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT luisakluth effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT philippmandel effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT felixkhchun effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients AT pierreikarakiewicz effectofchemotherapyonoverallsurvivalincontemporarymetastaticprostatecancerpatients
_version_	1718406637915471872

Effect of Chemotherapy on Overall Survival in Contemporary Metastatic Prostate Cancer Patients

Ejemplares similares