Higher Serum Phosphorus Is Not an Independent Risk Factor of Mortality in Heart Failure with Reduced Ejection Fraction

Higher serum phosphorus has detrimental health effects. Even high-normal rage sP is associated with worse outcomes. The relationship of serum phosphorus with prognostic markers in heart failure remains unclear. We investigated the association of serum phosphorus with heart failure prognostic factors...

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Autores principales:	Partyka Robert, Mroczek Alina, Duda Sylwia, Malinowska-Borowska Jolanta, Buczkowska Marta, Głogowska-Gruszka Anna, Niedziela Jacek, Hudzik Bartosz, Gąsior Mariusz, Rozentryt Piotr
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	serum phosphorus chronic heart failure prognosis all-cause mortality Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/97e488a14e124e87930878b05419f489
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spelling	oai:doaj.org-article:97e488a14e124e87930878b05419f4892021-11-25T18:35:58ZHigher Serum Phosphorus Is Not an Independent Risk Factor of Mortality in Heart Failure with Reduced Ejection Fraction10.3390/nu131140042072-6643https://doaj.org/article/97e488a14e124e87930878b05419f4892021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4004https://doaj.org/toc/2072-6643Higher serum phosphorus has detrimental health effects. Even high-normal rage sP is associated with worse outcomes. The relationship of serum phosphorus with prognostic markers in heart failure remains unclear. We investigated the association of serum phosphorus with heart failure prognostic factors and risk of mortality related to serum phosphorus. In 1029 stable heart failure patients, we investigated the distribution of markers of more advanced heart failure stage across quintiles of serum phosphorus and estimated the relative risk of mortality in comparison to reference. Higher serum phosphorus levels sP were associated with markers of a worse outcome. The best survival was observed in low-normal serum levels. The unadjusted hazard ratio for mortality increased toward higher phosphorus quintiles but not to lower levels of sP. The correction for age, sex, BMI, percent weight loss, inflammation, kidney function, and LVEF did not modify the risk profile substantially. The adjustment for NYHA, natriuretic peptides, serum sodium, and treatment characteristics broke down the risk relationship completely. A higher serum phosphorus is associated with markers of a more risky profile of heart failure. Elevated serum levels of phosphorus sP does not provide independent prognostic information beyond the strongest markers of the severity of the syndrome. The potential involvement of higher serum phosphorus as a mediator in the pathophysiology of heart failure warrants further study.Partyka RobertMroczek AlinaDuda SylwiaMalinowska-Borowska JolantaBuczkowska MartaGłogowska-Gruszka AnnaNiedziela JacekHudzik BartoszGąsior MariuszRozentryt PiotrMDPI AGarticleserum phosphoruschronic heart failureprognosisall-cause mortalityNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4004, p 4004 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	serum phosphorus chronic heart failure prognosis all-cause mortality Nutrition. Foods and food supply TX341-641
spellingShingle	serum phosphorus chronic heart failure prognosis all-cause mortality Nutrition. Foods and food supply TX341-641 Partyka Robert Mroczek Alina Duda Sylwia Malinowska-Borowska Jolanta Buczkowska Marta Głogowska-Gruszka Anna Niedziela Jacek Hudzik Bartosz Gąsior Mariusz Rozentryt Piotr Higher Serum Phosphorus Is Not an Independent Risk Factor of Mortality in Heart Failure with Reduced Ejection Fraction
description	Higher serum phosphorus has detrimental health effects. Even high-normal rage sP is associated with worse outcomes. The relationship of serum phosphorus with prognostic markers in heart failure remains unclear. We investigated the association of serum phosphorus with heart failure prognostic factors and risk of mortality related to serum phosphorus. In 1029 stable heart failure patients, we investigated the distribution of markers of more advanced heart failure stage across quintiles of serum phosphorus and estimated the relative risk of mortality in comparison to reference. Higher serum phosphorus levels sP were associated with markers of a worse outcome. The best survival was observed in low-normal serum levels. The unadjusted hazard ratio for mortality increased toward higher phosphorus quintiles but not to lower levels of sP. The correction for age, sex, BMI, percent weight loss, inflammation, kidney function, and LVEF did not modify the risk profile substantially. The adjustment for NYHA, natriuretic peptides, serum sodium, and treatment characteristics broke down the risk relationship completely. A higher serum phosphorus is associated with markers of a more risky profile of heart failure. Elevated serum levels of phosphorus sP does not provide independent prognostic information beyond the strongest markers of the severity of the syndrome. The potential involvement of higher serum phosphorus as a mediator in the pathophysiology of heart failure warrants further study.
format	article
author	Partyka Robert Mroczek Alina Duda Sylwia Malinowska-Borowska Jolanta Buczkowska Marta Głogowska-Gruszka Anna Niedziela Jacek Hudzik Bartosz Gąsior Mariusz Rozentryt Piotr
author_facet	Partyka Robert Mroczek Alina Duda Sylwia Malinowska-Borowska Jolanta Buczkowska Marta Głogowska-Gruszka Anna Niedziela Jacek Hudzik Bartosz Gąsior Mariusz Rozentryt Piotr
author_sort	Partyka Robert
title	Higher Serum Phosphorus Is Not an Independent Risk Factor of Mortality in Heart Failure with Reduced Ejection Fraction
title_short	Higher Serum Phosphorus Is Not an Independent Risk Factor of Mortality in Heart Failure with Reduced Ejection Fraction
title_full	Higher Serum Phosphorus Is Not an Independent Risk Factor of Mortality in Heart Failure with Reduced Ejection Fraction
title_fullStr	Higher Serum Phosphorus Is Not an Independent Risk Factor of Mortality in Heart Failure with Reduced Ejection Fraction
title_full_unstemmed	Higher Serum Phosphorus Is Not an Independent Risk Factor of Mortality in Heart Failure with Reduced Ejection Fraction
title_sort	higher serum phosphorus is not an independent risk factor of mortality in heart failure with reduced ejection fraction
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/97e488a14e124e87930878b05419f489
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Higher Serum Phosphorus Is Not an Independent Risk Factor of Mortality in Heart Failure with Reduced Ejection Fraction

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