Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in Caenorhabditis elegans

Ying-Fei Yang, Yi-Jun Lin, Chung-Min Liao Department of Bioenvironmental Systems Engineering, College of Bioresources and Agriculture, National Taiwan University, Taipei, Taiwan Abstract: Elucidating the relationships between the toxicity-based-toxicokinetic (TBTK)/toxicodynamic (TD) properties of...

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Autores principales:	Yang YF, Lin YJ, Liao CM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	zero-valent iron nanoparticles Caenorhabditis elegans nanotoxicology bioaccumulation toxicity-based toxicokinetic/toxicodynamic modeling Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/97e58332096e49049ac512c8aa15be86
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spelling	oai:doaj.org-article:97e58332096e49049ac512c8aa15be862021-12-02T04:28:16ZToxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in Caenorhabditis elegans1178-2013https://doaj.org/article/97e58332096e49049ac512c8aa15be862017-06-01T00:00:00Zhttps://www.dovepress.com/toxicity-based-toxicokinetictoxicodynamic-assessment-of-bioaccumulatio-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ying-Fei Yang, Yi-Jun Lin, Chung-Min Liao Department of Bioenvironmental Systems Engineering, College of Bioresources and Agriculture, National Taiwan University, Taipei, Taiwan Abstract: Elucidating the relationships between the toxicity-based-toxicokinetic (TBTK)/toxicodynamic (TD) properties of engineered nanomaterials and their nanotoxicity is crucial for human health-risk analysis. Zerovalent iron (Fe0) nanoparticles (NPs) are one of the most prominent NPs applied in remediating contaminated soils and groundwater. However, there are concerns that Fe0NP application contributes to long-term environmental and human health impacts. The nematode Caenorhabditis elegans is a surrogate in vivo model that has been successfully applied to assess the potential nanotoxicity of these nanomaterials. Here we present a TBTK/TD approach to appraise bioaccumulation and nanotoxicity of Fe0NPs in C. elegans. Built on a present C. elegans bioassay with estimated TBTK/TD parameters, we found that average bioconcentration factors in C. elegans exposed to waterborne and food-borne Fe0NPs were ~50 and ~5×10–3, respectively, whereas 10% inhibition concentrations for fertility, locomotion, and development, were 1.26 (95% CI 0.19–5.2), 3.84 (0.38–42), and 6.78 (2.58–21) µg·g–1, respectively, implicating that fertility is the most sensitive endpoint in C. elegans. Our results also showed that biomagnification effects were not observed in waterborne or food-borne Fe0NP-exposed worms. We suggest that the TBTK/TD assessment for predicting NP-induced toxicity at different concentrations and conditions in C. elegans could enable rapid selection of nanomaterials that are more likely to be nontoxic in larger animals. We conclude that the use of the TBTK/TD scheme manipulating C. elegans could be used for rapid evaluation of in vivo toxicity of NPs or for drug screening in the field of nanomedicine. Keywords: zerovalent iron nanoparticles, Caenorhabditis elegans, nanotoxicology, bioaccumulation, toxicity-based-toxicokinetic/toxicodynamic modelingYang YFLin YJLiao CMDove Medical Pressarticlezero-valent iron nanoparticlesCaenorhabditis elegansnanotoxicologybioaccumulationtoxicity-based toxicokinetic/toxicodynamic modelingMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 4607-4621 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	zero-valent iron nanoparticles Caenorhabditis elegans nanotoxicology bioaccumulation toxicity-based toxicokinetic/toxicodynamic modeling Medicine (General) R5-920
spellingShingle	zero-valent iron nanoparticles Caenorhabditis elegans nanotoxicology bioaccumulation toxicity-based toxicokinetic/toxicodynamic modeling Medicine (General) R5-920 Yang YF Lin YJ Liao CM Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in Caenorhabditis elegans
description	Ying-Fei Yang, Yi-Jun Lin, Chung-Min Liao Department of Bioenvironmental Systems Engineering, College of Bioresources and Agriculture, National Taiwan University, Taipei, Taiwan Abstract: Elucidating the relationships between the toxicity-based-toxicokinetic (TBTK)/toxicodynamic (TD) properties of engineered nanomaterials and their nanotoxicity is crucial for human health-risk analysis. Zerovalent iron (Fe0) nanoparticles (NPs) are one of the most prominent NPs applied in remediating contaminated soils and groundwater. However, there are concerns that Fe0NP application contributes to long-term environmental and human health impacts. The nematode Caenorhabditis elegans is a surrogate in vivo model that has been successfully applied to assess the potential nanotoxicity of these nanomaterials. Here we present a TBTK/TD approach to appraise bioaccumulation and nanotoxicity of Fe0NPs in C. elegans. Built on a present C. elegans bioassay with estimated TBTK/TD parameters, we found that average bioconcentration factors in C. elegans exposed to waterborne and food-borne Fe0NPs were ~50 and ~5×10–3, respectively, whereas 10% inhibition concentrations for fertility, locomotion, and development, were 1.26 (95% CI 0.19–5.2), 3.84 (0.38–42), and 6.78 (2.58–21) µg·g–1, respectively, implicating that fertility is the most sensitive endpoint in C. elegans. Our results also showed that biomagnification effects were not observed in waterborne or food-borne Fe0NP-exposed worms. We suggest that the TBTK/TD assessment for predicting NP-induced toxicity at different concentrations and conditions in C. elegans could enable rapid selection of nanomaterials that are more likely to be nontoxic in larger animals. We conclude that the use of the TBTK/TD scheme manipulating C. elegans could be used for rapid evaluation of in vivo toxicity of NPs or for drug screening in the field of nanomedicine. Keywords: zerovalent iron nanoparticles, Caenorhabditis elegans, nanotoxicology, bioaccumulation, toxicity-based-toxicokinetic/toxicodynamic modeling
format	article
author	Yang YF Lin YJ Liao CM
author_facet	Yang YF Lin YJ Liao CM
author_sort	Yang YF
title	Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in Caenorhabditis elegans
title_short	Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in Caenorhabditis elegans
title_full	Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in Caenorhabditis elegans
title_fullStr	Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in Caenorhabditis elegans
title_full_unstemmed	Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in Caenorhabditis elegans
title_sort	toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in caenorhabditis elegans
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/97e58332096e49049ac512c8aa15be86
work_keys_str_mv	AT yangyf toxicitybasedtoxicokinetictoxicodynamicassessmentofbioaccumulationandnanotoxicityofzerovalentironnanoparticlesincaenorhabditiselegans AT linyj toxicitybasedtoxicokinetictoxicodynamicassessmentofbioaccumulationandnanotoxicityofzerovalentironnanoparticlesincaenorhabditiselegans AT liaocm toxicitybasedtoxicokinetictoxicodynamicassessmentofbioaccumulationandnanotoxicityofzerovalentironnanoparticlesincaenorhabditiselegans
_version_	1718401203241484288

Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in Caenorhabditis elegans

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