In-field stereotactic body radiotherapy (SBRT) reirradiation for pulmonary malignancies as a multicentre analysis of the German Society of Radiation Oncology (DEGRO)

Abstract Data of thoracic in-field reirradiation with two courses of stereotactic body radiotherapy (SBRT) is scarce. Aim of this study is to investigate feasibility and safety of this approach. Patients with a second course of thoracic SBRT and planning target volume (PTV) overlap were analyzed in...

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Autores principales:	Caroline John, Riccardo Dal Bello, Nicolaus Andratschke, Matthias Guckenberger, Judit Boda-Heggemann, Eleni Gkika, Frederick Mantel, Hanno M. Specht, Carmen Stromberger, Franz Zehentmayr, Oliver Blanck, Panagiotis Balermpas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/97e6418881f24744aa53063fb62cee62
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spelling	oai:doaj.org-article:97e6418881f24744aa53063fb62cee622021-12-02T11:35:57ZIn-field stereotactic body radiotherapy (SBRT) reirradiation for pulmonary malignancies as a multicentre analysis of the German Society of Radiation Oncology (DEGRO)10.1038/s41598-021-83210-32045-2322https://doaj.org/article/97e6418881f24744aa53063fb62cee622021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83210-3https://doaj.org/toc/2045-2322Abstract Data of thoracic in-field reirradiation with two courses of stereotactic body radiotherapy (SBRT) is scarce. Aim of this study is to investigate feasibility and safety of this approach. Patients with a second course of thoracic SBRT and planning target volume (PTV) overlap were analyzed in this retrospective, multicenter study. All plans and clinical data were centrally collected. 27 patients from 8 centers have been amenable for evaluation: 12 with non-small-cell lung cancer, 16 with metastases, treated from 2009 (oldest first course) to 2020 (latest second course). A median dose of 38.5 Gy to the 65%-isodose over a median of 5 fractions was prescribed in the first course and 40 Gy in 5 fractions for the second SBRT-course. Median PTV of the second SBRT was 29.5 cm3, median PTV overlap 22 cm3. With a median interval of 20.2 months between the two SBRT-courses, 1-year OS, and -LCR were 78.3% and 70.3% respectively. 3 patients developed grade 1 and one grade 2 pneumonitis. No grade > 2 toxicity was observed. Peripheral location and dose were the only factors correlating with tumor control. A second SBRT-course with PTV overlap appears safe and achieves reasonable local control.Caroline JohnRiccardo Dal BelloNicolaus AndratschkeMatthias GuckenbergerJudit Boda-HeggemannEleni GkikaFrederick MantelHanno M. SpechtCarmen StrombergerFranz ZehentmayrOliver BlanckPanagiotis BalermpasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Caroline John Riccardo Dal Bello Nicolaus Andratschke Matthias Guckenberger Judit Boda-Heggemann Eleni Gkika Frederick Mantel Hanno M. Specht Carmen Stromberger Franz Zehentmayr Oliver Blanck Panagiotis Balermpas In-field stereotactic body radiotherapy (SBRT) reirradiation for pulmonary malignancies as a multicentre analysis of the German Society of Radiation Oncology (DEGRO)
description	Abstract Data of thoracic in-field reirradiation with two courses of stereotactic body radiotherapy (SBRT) is scarce. Aim of this study is to investigate feasibility and safety of this approach. Patients with a second course of thoracic SBRT and planning target volume (PTV) overlap were analyzed in this retrospective, multicenter study. All plans and clinical data were centrally collected. 27 patients from 8 centers have been amenable for evaluation: 12 with non-small-cell lung cancer, 16 with metastases, treated from 2009 (oldest first course) to 2020 (latest second course). A median dose of 38.5 Gy to the 65%-isodose over a median of 5 fractions was prescribed in the first course and 40 Gy in 5 fractions for the second SBRT-course. Median PTV of the second SBRT was 29.5 cm3, median PTV overlap 22 cm3. With a median interval of 20.2 months between the two SBRT-courses, 1-year OS, and -LCR were 78.3% and 70.3% respectively. 3 patients developed grade 1 and one grade 2 pneumonitis. No grade > 2 toxicity was observed. Peripheral location and dose were the only factors correlating with tumor control. A second SBRT-course with PTV overlap appears safe and achieves reasonable local control.
format	article
author	Caroline John Riccardo Dal Bello Nicolaus Andratschke Matthias Guckenberger Judit Boda-Heggemann Eleni Gkika Frederick Mantel Hanno M. Specht Carmen Stromberger Franz Zehentmayr Oliver Blanck Panagiotis Balermpas
author_facet	Caroline John Riccardo Dal Bello Nicolaus Andratschke Matthias Guckenberger Judit Boda-Heggemann Eleni Gkika Frederick Mantel Hanno M. Specht Carmen Stromberger Franz Zehentmayr Oliver Blanck Panagiotis Balermpas
author_sort	Caroline John
title	In-field stereotactic body radiotherapy (SBRT) reirradiation for pulmonary malignancies as a multicentre analysis of the German Society of Radiation Oncology (DEGRO)
title_short	In-field stereotactic body radiotherapy (SBRT) reirradiation for pulmonary malignancies as a multicentre analysis of the German Society of Radiation Oncology (DEGRO)
title_full	In-field stereotactic body radiotherapy (SBRT) reirradiation for pulmonary malignancies as a multicentre analysis of the German Society of Radiation Oncology (DEGRO)
title_fullStr	In-field stereotactic body radiotherapy (SBRT) reirradiation for pulmonary malignancies as a multicentre analysis of the German Society of Radiation Oncology (DEGRO)
title_full_unstemmed	In-field stereotactic body radiotherapy (SBRT) reirradiation for pulmonary malignancies as a multicentre analysis of the German Society of Radiation Oncology (DEGRO)
title_sort	in-field stereotactic body radiotherapy (sbrt) reirradiation for pulmonary malignancies as a multicentre analysis of the german society of radiation oncology (degro)
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/97e6418881f24744aa53063fb62cee62
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In-field stereotactic body radiotherapy (SBRT) reirradiation for pulmonary malignancies as a multicentre analysis of the German Society of Radiation Oncology (DEGRO)

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