Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome

Mutations in potassium and calcium channel genes have been associated with cardiac arrhythmias. Here, Jensen et al. show that an anion transporter chloride-bicarbonate exchanger AE3 is also responsible for the genetically-induced mechanism of cardiac arrhythmia, suggesting new therapeutic targets fo...

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Autores principales:	Kasper Thorsen, Vibeke S. Dam, Kasper Kjaer-Sorensen, Lisbeth N. Pedersen, V. Arvydas Skeberdis, Jonas Jurevičius, Rimantas Treinys, Ida M. B. S. Petersen, Morten S. Nielsen, Claus Oxvig, J. Preben Morth, Vladimir V. Matchkov, Christian Aalkjær, Henning Bundgaard, Henrik K. Jensen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/97e6cbf2131e4127b04d04f0aede118d
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spelling	oai:doaj.org-article:97e6cbf2131e4127b04d04f0aede118d2021-12-02T14:40:58ZLoss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome10.1038/s41467-017-01630-02041-1723https://doaj.org/article/97e6cbf2131e4127b04d04f0aede118d2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01630-0https://doaj.org/toc/2041-1723Mutations in potassium and calcium channel genes have been associated with cardiac arrhythmias. Here, Jensen et al. show that an anion transporter chloride-bicarbonate exchanger AE3 is also responsible for the genetically-induced mechanism of cardiac arrhythmia, suggesting new therapeutic targets for this diseaseKasper ThorsenVibeke S. DamKasper Kjaer-SorensenLisbeth N. PedersenV. Arvydas SkeberdisJonas JurevičiusRimantas TreinysIda M. B. S. PetersenMorten S. NielsenClaus OxvigJ. Preben MorthVladimir V. MatchkovChristian AalkjærHenning BundgaardHenrik K. JensenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kasper Thorsen Vibeke S. Dam Kasper Kjaer-Sorensen Lisbeth N. Pedersen V. Arvydas Skeberdis Jonas Jurevičius Rimantas Treinys Ida M. B. S. Petersen Morten S. Nielsen Claus Oxvig J. Preben Morth Vladimir V. Matchkov Christian Aalkjær Henning Bundgaard Henrik K. Jensen Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome
description	Mutations in potassium and calcium channel genes have been associated with cardiac arrhythmias. Here, Jensen et al. show that an anion transporter chloride-bicarbonate exchanger AE3 is also responsible for the genetically-induced mechanism of cardiac arrhythmia, suggesting new therapeutic targets for this disease
format	article
author	Kasper Thorsen Vibeke S. Dam Kasper Kjaer-Sorensen Lisbeth N. Pedersen V. Arvydas Skeberdis Jonas Jurevičius Rimantas Treinys Ida M. B. S. Petersen Morten S. Nielsen Claus Oxvig J. Preben Morth Vladimir V. Matchkov Christian Aalkjær Henning Bundgaard Henrik K. Jensen
author_facet	Kasper Thorsen Vibeke S. Dam Kasper Kjaer-Sorensen Lisbeth N. Pedersen V. Arvydas Skeberdis Jonas Jurevičius Rimantas Treinys Ida M. B. S. Petersen Morten S. Nielsen Claus Oxvig J. Preben Morth Vladimir V. Matchkov Christian Aalkjær Henning Bundgaard Henrik K. Jensen
author_sort	Kasper Thorsen
title	Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome
title_short	Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome
title_full	Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome
title_fullStr	Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome
title_full_unstemmed	Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome
title_sort	loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger ae3 causes short qt syndrome
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/97e6cbf2131e4127b04d04f0aede118d
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Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome

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