The making of a potent L-lactate transport inhibitor

The L-lactate-specific transporter SfMCT is a model SLC16 family homologue for the determination of inhibitors and potential drugs. Here, starting from a weakly-binding non-transported ligand, nanomolar affinity inhibitors of SfMCT are developed and crystal structures of the transporter-ligand compl...

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Autores principales:	Patrick D. Bosshart, David Kalbermatter, Sara Bonetti, Dimitrios Fotiadis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/97e83b41fe4545f685b939f7980553da
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spelling	oai:doaj.org-article:97e83b41fe4545f685b939f7980553da2021-12-02T17:20:38ZThe making of a potent L-lactate transport inhibitor10.1038/s42004-021-00564-52399-3669https://doaj.org/article/97e83b41fe4545f685b939f7980553da2021-09-01T00:00:00Zhttps://doi.org/10.1038/s42004-021-00564-5https://doaj.org/toc/2399-3669The L-lactate-specific transporter SfMCT is a model SLC16 family homologue for the determination of inhibitors and potential drugs. Here, starting from a weakly-binding non-transported ligand, nanomolar affinity inhibitors of SfMCT are developed and crystal structures of the transporter-ligand complexes are presented unveiling interactions at the atomic level.Patrick D. BosshartDavid KalbermatterSara BonettiDimitrios FotiadisNature PortfolioarticleChemistryQD1-999ENCommunications Chemistry, Vol 4, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemistry QD1-999
spellingShingle	Chemistry QD1-999 Patrick D. Bosshart David Kalbermatter Sara Bonetti Dimitrios Fotiadis The making of a potent L-lactate transport inhibitor
description	The L-lactate-specific transporter SfMCT is a model SLC16 family homologue for the determination of inhibitors and potential drugs. Here, starting from a weakly-binding non-transported ligand, nanomolar affinity inhibitors of SfMCT are developed and crystal structures of the transporter-ligand complexes are presented unveiling interactions at the atomic level.
format	article
author	Patrick D. Bosshart David Kalbermatter Sara Bonetti Dimitrios Fotiadis
author_facet	Patrick D. Bosshart David Kalbermatter Sara Bonetti Dimitrios Fotiadis
author_sort	Patrick D. Bosshart
title	The making of a potent L-lactate transport inhibitor
title_short	The making of a potent L-lactate transport inhibitor
title_full	The making of a potent L-lactate transport inhibitor
title_fullStr	The making of a potent L-lactate transport inhibitor
title_full_unstemmed	The making of a potent L-lactate transport inhibitor
title_sort	making of a potent l-lactate transport inhibitor
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/97e83b41fe4545f685b939f7980553da
work_keys_str_mv	AT patrickdbosshart themakingofapotentllactatetransportinhibitor AT davidkalbermatter themakingofapotentllactatetransportinhibitor AT sarabonetti themakingofapotentllactatetransportinhibitor AT dimitriosfotiadis themakingofapotentllactatetransportinhibitor AT patrickdbosshart makingofapotentllactatetransportinhibitor AT davidkalbermatter makingofapotentllactatetransportinhibitor AT sarabonetti makingofapotentllactatetransportinhibitor AT dimitriosfotiadis makingofapotentllactatetransportinhibitor
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The making of a potent L-lactate transport inhibitor

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