ncRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery

Non-coding RNAs (ncRNAs) are emerging therapeutic tools but there are barriers to their translation to clinical practice. Key issues concern the specificity of the targets, the delivery of the molecules, and their stability, while avoiding “on-target” and “off-target” side effects. In this “ncRNA in...

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Autores principales:	Miguel Hueso, Adrián Mallén, Marc Suñé-Pou, Josep M. Aran, Josep M. Suñé-Negre, Estanislao Navarro
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ncRNAs nanotechnology oligonucleotide therapy delivery vehicles nanoparticles Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/97e85df3e1ae4eb990b296c78749e545
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spelling	oai:doaj.org-article:97e85df3e1ae4eb990b296c78749e5452021-11-11T17:04:33ZncRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery10.3390/ijms2221115961422-00671661-6596https://doaj.org/article/97e85df3e1ae4eb990b296c78749e5452021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11596https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Non-coding RNAs (ncRNAs) are emerging therapeutic tools but there are barriers to their translation to clinical practice. Key issues concern the specificity of the targets, the delivery of the molecules, and their stability, while avoiding “on-target” and “off-target” side effects. In this “ncRNA in therapeutics” issue, we collect several studies of the differential expression of ncRNAs in cardiovascular diseases, bone metabolism-related disorders, neurology, and oncology, and their potential to be used as biomarkers or therapeutic targets. Moreover, we review recent advances in the use of antisense ncRNAs in targeted therapies with a particular emphasis on their basic biological mechanisms, their translational potential, and future trends.Miguel HuesoAdrián MallénMarc Suñé-PouJosep M. AranJosep M. Suñé-NegreEstanislao NavarroMDPI AGarticlencRNAsnanotechnologyoligonucleotide therapydelivery vehiclesnanoparticlesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11596, p 11596 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ncRNAs nanotechnology oligonucleotide therapy delivery vehicles nanoparticles Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	ncRNAs nanotechnology oligonucleotide therapy delivery vehicles nanoparticles Biology (General) QH301-705.5 Chemistry QD1-999 Miguel Hueso Adrián Mallén Marc Suñé-Pou Josep M. Aran Josep M. Suñé-Negre Estanislao Navarro ncRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery
description	Non-coding RNAs (ncRNAs) are emerging therapeutic tools but there are barriers to their translation to clinical practice. Key issues concern the specificity of the targets, the delivery of the molecules, and their stability, while avoiding “on-target” and “off-target” side effects. In this “ncRNA in therapeutics” issue, we collect several studies of the differential expression of ncRNAs in cardiovascular diseases, bone metabolism-related disorders, neurology, and oncology, and their potential to be used as biomarkers or therapeutic targets. Moreover, we review recent advances in the use of antisense ncRNAs in targeted therapies with a particular emphasis on their basic biological mechanisms, their translational potential, and future trends.
format	article
author	Miguel Hueso Adrián Mallén Marc Suñé-Pou Josep M. Aran Josep M. Suñé-Negre Estanislao Navarro
author_facet	Miguel Hueso Adrián Mallén Marc Suñé-Pou Josep M. Aran Josep M. Suñé-Negre Estanislao Navarro
author_sort	Miguel Hueso
title	ncRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery
title_short	ncRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery
title_full	ncRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery
title_fullStr	ncRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery
title_full_unstemmed	ncRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery
title_sort	ncrnas in therapeutics: challenges and limitations in nucleic acid-based drug delivery
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/97e85df3e1ae4eb990b296c78749e545
work_keys_str_mv	AT miguelhueso ncrnasintherapeuticschallengesandlimitationsinnucleicacidbaseddrugdelivery AT adrianmallen ncrnasintherapeuticschallengesandlimitationsinnucleicacidbaseddrugdelivery AT marcsunepou ncrnasintherapeuticschallengesandlimitationsinnucleicacidbaseddrugdelivery AT josepmaran ncrnasintherapeuticschallengesandlimitationsinnucleicacidbaseddrugdelivery AT josepmsunenegre ncrnasintherapeuticschallengesandlimitationsinnucleicacidbaseddrugdelivery AT estanislaonavarro ncrnasintherapeuticschallengesandlimitationsinnucleicacidbaseddrugdelivery
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ncRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery

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