Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma
Immunotherapies now dominate the treatment landscape for melanoma, but why they only work in a subset of patients remains unclear. Here, the authors perform an immunogenomic analysis on 67 intratumor sub-regions of a PD-1 inhibitor resistant melanoma, and 2 additional metastases from a single patien...
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Nature Portfolio
2020
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oai:doaj.org-article:97e9b4c4c8f048e9a752f694b5bd17ef2021-12-02T17:33:14ZSpatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma10.1038/s41467-020-15538-92041-1723https://doaj.org/article/97e9b4c4c8f048e9a752f694b5bd17ef2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15538-9https://doaj.org/toc/2041-1723Immunotherapies now dominate the treatment landscape for melanoma, but why they only work in a subset of patients remains unclear. Here, the authors perform an immunogenomic analysis on 67 intratumor sub-regions of a PD-1 inhibitor resistant melanoma, and 2 additional metastases from a single patient, mapping the spatial relationships between genomic and immune heterogeneity at high resolution.Akash MitraMiles C. AndrewsWhijae RohMarianna Petaccia De MacedoCourtney W. HudgensFernando CarapetoShailbala SinghAlexandre ReubenFeng WangXizeng MaoXingzhi SongKhalida WaniSamantha TippenKwok-Shing NgAislyn SchalckDonald A. Sakellariou-ThompsonEveline ChenSangeetha M. ReddyChristine N. SpencerDiana WiesnoskiLatasha D. LittleCurtis GumbsZachary A. CooperElizabeth M. BurtonPatrick HwuMichael A. DaviesJianhua ZhangChantale BernatchezNicholas NavinPadmanee SharmaJames P. AllisonJennifer A. WargoCassian YeeMichael T. TetzlaffWen-Jen HwuAlexander J. LazarP. Andrew FutrealNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020) |
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DOAJ |
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Science Q Akash Mitra Miles C. Andrews Whijae Roh Marianna Petaccia De Macedo Courtney W. Hudgens Fernando Carapeto Shailbala Singh Alexandre Reuben Feng Wang Xizeng Mao Xingzhi Song Khalida Wani Samantha Tippen Kwok-Shing Ng Aislyn Schalck Donald A. Sakellariou-Thompson Eveline Chen Sangeetha M. Reddy Christine N. Spencer Diana Wiesnoski Latasha D. Little Curtis Gumbs Zachary A. Cooper Elizabeth M. Burton Patrick Hwu Michael A. Davies Jianhua Zhang Chantale Bernatchez Nicholas Navin Padmanee Sharma James P. Allison Jennifer A. Wargo Cassian Yee Michael T. Tetzlaff Wen-Jen Hwu Alexander J. Lazar P. Andrew Futreal Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma |
| description |
Immunotherapies now dominate the treatment landscape for melanoma, but why they only work in a subset of patients remains unclear. Here, the authors perform an immunogenomic analysis on 67 intratumor sub-regions of a PD-1 inhibitor resistant melanoma, and 2 additional metastases from a single patient, mapping the spatial relationships between genomic and immune heterogeneity at high resolution. |
| format |
article |
| author |
Akash Mitra Miles C. Andrews Whijae Roh Marianna Petaccia De Macedo Courtney W. Hudgens Fernando Carapeto Shailbala Singh Alexandre Reuben Feng Wang Xizeng Mao Xingzhi Song Khalida Wani Samantha Tippen Kwok-Shing Ng Aislyn Schalck Donald A. Sakellariou-Thompson Eveline Chen Sangeetha M. Reddy Christine N. Spencer Diana Wiesnoski Latasha D. Little Curtis Gumbs Zachary A. Cooper Elizabeth M. Burton Patrick Hwu Michael A. Davies Jianhua Zhang Chantale Bernatchez Nicholas Navin Padmanee Sharma James P. Allison Jennifer A. Wargo Cassian Yee Michael T. Tetzlaff Wen-Jen Hwu Alexander J. Lazar P. Andrew Futreal |
| author_facet |
Akash Mitra Miles C. Andrews Whijae Roh Marianna Petaccia De Macedo Courtney W. Hudgens Fernando Carapeto Shailbala Singh Alexandre Reuben Feng Wang Xizeng Mao Xingzhi Song Khalida Wani Samantha Tippen Kwok-Shing Ng Aislyn Schalck Donald A. Sakellariou-Thompson Eveline Chen Sangeetha M. Reddy Christine N. Spencer Diana Wiesnoski Latasha D. Little Curtis Gumbs Zachary A. Cooper Elizabeth M. Burton Patrick Hwu Michael A. Davies Jianhua Zhang Chantale Bernatchez Nicholas Navin Padmanee Sharma James P. Allison Jennifer A. Wargo Cassian Yee Michael T. Tetzlaff Wen-Jen Hwu Alexander J. Lazar P. Andrew Futreal |
| author_sort |
Akash Mitra |
| title |
Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma |
| title_short |
Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma |
| title_full |
Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma |
| title_fullStr |
Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma |
| title_full_unstemmed |
Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma |
| title_sort |
spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/97e9b4c4c8f048e9a752f694b5bd17ef |
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1718380013015793664 |