Anti-PD-1 Therapy—A Potential Treatment for Myocardial Metastasis From Nasopharyngeal Carcinoma: A Case Report

Myocardial metastasis of nasopharyngeal carcinoma (NPC) is rarely reported in the literature. Some autopsy studies found metastases in more than 10% of cases with malignant neoplasm. However, patients are often diagnosed during the postmortem because myocardial metastasis is often asymptomatic, and...

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Autores principales:	Xiaowan Tang, Weijun Zhou, Danjiang Huang, Lili Chen, Guangwen Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	nasopharyngeal carcinoma head and neck tumor myocardial metastasis immunotherapy anti-PD-1 therapy Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/97ec1dcf78f745f989c8387fc7399832
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spelling	oai:doaj.org-article:97ec1dcf78f745f989c8387fc73998322021-11-05T06:59:15ZAnti-PD-1 Therapy—A Potential Treatment for Myocardial Metastasis From Nasopharyngeal Carcinoma: A Case Report1664-322410.3389/fimmu.2021.688682https://doaj.org/article/97ec1dcf78f745f989c8387fc73998322021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.688682/fullhttps://doaj.org/toc/1664-3224Myocardial metastasis of nasopharyngeal carcinoma (NPC) is rarely reported in the literature. Some autopsy studies found metastases in more than 10% of cases with malignant neoplasm. However, patients are often diagnosed during the postmortem because myocardial metastasis is often asymptomatic, and its Cardiac complications tend to be severe and fatal. Patients with Cardiac metastases are often treated with chemotherapy or surgical intervention, although the prognosis is poor. Immunotherapy with anti-programmed cell death receptor-1 or ligand-1 (PD-1 or PD-L1) inhibitors has recently been reported to be therapeutically significant in multiple cancers, including melanoma, nonsmall cell lung cancer, and NPC, but the treatment of myocardial metastasis of NPC has not been reported. This study described the case of a 50-year-old male patient who presented initially with NPC and received radiotherapy as first-line therapy. For 20 years, he had recurrent Cardiac metastasis of NPC. The pathological examination suggested tPD-L1 expression. Therefore, off-label sintilimab (200 mg every 21 days) was administered. After 10 cycles of treatment, myocardial metastasis shrank and the enlarged mediastinal lymph nodes disappeared. This case report demonstrated that Cardiac metastasis of NPC expressing PD-L1 might have a sustained response to PD-L1 inhibitor–directed therapy.Xiaowan TangWeijun ZhouDanjiang HuangLili ChenGuangwen ZhangFrontiers Media S.A.articlenasopharyngeal carcinomahead and neck tumormyocardial metastasisimmunotherapyanti-PD-1 therapyImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nasopharyngeal carcinoma head and neck tumor myocardial metastasis immunotherapy anti-PD-1 therapy Immunologic diseases. Allergy RC581-607
spellingShingle	nasopharyngeal carcinoma head and neck tumor myocardial metastasis immunotherapy anti-PD-1 therapy Immunologic diseases. Allergy RC581-607 Xiaowan Tang Weijun Zhou Danjiang Huang Lili Chen Guangwen Zhang Anti-PD-1 Therapy—A Potential Treatment for Myocardial Metastasis From Nasopharyngeal Carcinoma: A Case Report
description	Myocardial metastasis of nasopharyngeal carcinoma (NPC) is rarely reported in the literature. Some autopsy studies found metastases in more than 10% of cases with malignant neoplasm. However, patients are often diagnosed during the postmortem because myocardial metastasis is often asymptomatic, and its Cardiac complications tend to be severe and fatal. Patients with Cardiac metastases are often treated with chemotherapy or surgical intervention, although the prognosis is poor. Immunotherapy with anti-programmed cell death receptor-1 or ligand-1 (PD-1 or PD-L1) inhibitors has recently been reported to be therapeutically significant in multiple cancers, including melanoma, nonsmall cell lung cancer, and NPC, but the treatment of myocardial metastasis of NPC has not been reported. This study described the case of a 50-year-old male patient who presented initially with NPC and received radiotherapy as first-line therapy. For 20 years, he had recurrent Cardiac metastasis of NPC. The pathological examination suggested tPD-L1 expression. Therefore, off-label sintilimab (200 mg every 21 days) was administered. After 10 cycles of treatment, myocardial metastasis shrank and the enlarged mediastinal lymph nodes disappeared. This case report demonstrated that Cardiac metastasis of NPC expressing PD-L1 might have a sustained response to PD-L1 inhibitor–directed therapy.
format	article
author	Xiaowan Tang Weijun Zhou Danjiang Huang Lili Chen Guangwen Zhang
author_facet	Xiaowan Tang Weijun Zhou Danjiang Huang Lili Chen Guangwen Zhang
author_sort	Xiaowan Tang
title	Anti-PD-1 Therapy—A Potential Treatment for Myocardial Metastasis From Nasopharyngeal Carcinoma: A Case Report
title_short	Anti-PD-1 Therapy—A Potential Treatment for Myocardial Metastasis From Nasopharyngeal Carcinoma: A Case Report
title_full	Anti-PD-1 Therapy—A Potential Treatment for Myocardial Metastasis From Nasopharyngeal Carcinoma: A Case Report
title_fullStr	Anti-PD-1 Therapy—A Potential Treatment for Myocardial Metastasis From Nasopharyngeal Carcinoma: A Case Report
title_full_unstemmed	Anti-PD-1 Therapy—A Potential Treatment for Myocardial Metastasis From Nasopharyngeal Carcinoma: A Case Report
title_sort	anti-pd-1 therapy—a potential treatment for myocardial metastasis from nasopharyngeal carcinoma: a case report
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/97ec1dcf78f745f989c8387fc7399832
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Anti-PD-1 Therapy—A Potential Treatment for Myocardial Metastasis From Nasopharyngeal Carcinoma: A Case Report

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