Major Phytocannabinoids and Their Related Compounds: Should We Only Search for Drugs That Act on Cannabinoid Receptors?

The most important discoveries in pharmacology, such as certain classes of analgesics or chemotherapeutics, started from natural extracts which have been found to have effects in traditional medicine. Cannabis, traditionally used in Asia for the treatment of pain, nausea, spasms, sleep, depression,...

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Autores principales:	Leontina Elena Filipiuc, Daniela Carmen Ababei, Teodora Alexa-Stratulat, Cosmin Vasilica Pricope, Veronica Bild, Raluca Stefanescu, Gabriela Dumitrita Stanciu, Bogdan-Ionel Tamba
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	phytocannabinoids cannabigerol cannabidiol tetrahydrocannabinol synthetic cannabinoids cannabinoid receptors Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/97f09f738f7948c4b52915df53435125
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spelling	oai:doaj.org-article:97f09f738f7948c4b52915df534351252021-11-25T18:40:56ZMajor Phytocannabinoids and Their Related Compounds: Should We Only Search for Drugs That Act on Cannabinoid Receptors?10.3390/pharmaceutics131118231999-4923https://doaj.org/article/97f09f738f7948c4b52915df534351252021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1823https://doaj.org/toc/1999-4923The most important discoveries in pharmacology, such as certain classes of analgesics or chemotherapeutics, started from natural extracts which have been found to have effects in traditional medicine. Cannabis, traditionally used in Asia for the treatment of pain, nausea, spasms, sleep, depression, and low appetite, is still a good candidate for the development of new compounds. If initially all attention was directed to the endocannabinoid system, recent studies suggest that many of the clinically proven effects are based on an intrinsic chain of mechanisms that do not necessarily involve only cannabinoid receptors. Recent research has shown that major phytocannabinoids and their derivatives also interact with non-cannabinoid receptors such as vanilloid receptor 1, transient receptor ankyrin 1 potential, peroxisome proliferator-activated receptor-gamma or glitazone receptor, G55 protein-coupled receptor, and nuclear receptor, producing pharmacological effects in diseases such as Alzheimer’s, epilepsy, depression, neuropathic pain, cancer, and diabetes. Nonetheless, further studies are needed to elucidate the precise mechanisms of these compounds. Structure modulation of phytocannabinoids, in order to improve pharmacological effects, should not be limited to the exploration of cannabinoid receptors, and it should target other courses of action discovered through recent research.Leontina Elena FilipiucDaniela Carmen AbabeiTeodora Alexa-StratulatCosmin Vasilica PricopeVeronica BildRaluca StefanescuGabriela Dumitrita StanciuBogdan-Ionel TambaMDPI AGarticlephytocannabinoidscannabigerolcannabidioltetrahydrocannabinolsynthetic cannabinoidscannabinoid receptorsPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1823, p 1823 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	phytocannabinoids cannabigerol cannabidiol tetrahydrocannabinol synthetic cannabinoids cannabinoid receptors Pharmacy and materia medica RS1-441
spellingShingle	phytocannabinoids cannabigerol cannabidiol tetrahydrocannabinol synthetic cannabinoids cannabinoid receptors Pharmacy and materia medica RS1-441 Leontina Elena Filipiuc Daniela Carmen Ababei Teodora Alexa-Stratulat Cosmin Vasilica Pricope Veronica Bild Raluca Stefanescu Gabriela Dumitrita Stanciu Bogdan-Ionel Tamba Major Phytocannabinoids and Their Related Compounds: Should We Only Search for Drugs That Act on Cannabinoid Receptors?
description	The most important discoveries in pharmacology, such as certain classes of analgesics or chemotherapeutics, started from natural extracts which have been found to have effects in traditional medicine. Cannabis, traditionally used in Asia for the treatment of pain, nausea, spasms, sleep, depression, and low appetite, is still a good candidate for the development of new compounds. If initially all attention was directed to the endocannabinoid system, recent studies suggest that many of the clinically proven effects are based on an intrinsic chain of mechanisms that do not necessarily involve only cannabinoid receptors. Recent research has shown that major phytocannabinoids and their derivatives also interact with non-cannabinoid receptors such as vanilloid receptor 1, transient receptor ankyrin 1 potential, peroxisome proliferator-activated receptor-gamma or glitazone receptor, G55 protein-coupled receptor, and nuclear receptor, producing pharmacological effects in diseases such as Alzheimer’s, epilepsy, depression, neuropathic pain, cancer, and diabetes. Nonetheless, further studies are needed to elucidate the precise mechanisms of these compounds. Structure modulation of phytocannabinoids, in order to improve pharmacological effects, should not be limited to the exploration of cannabinoid receptors, and it should target other courses of action discovered through recent research.
format	article
author	Leontina Elena Filipiuc Daniela Carmen Ababei Teodora Alexa-Stratulat Cosmin Vasilica Pricope Veronica Bild Raluca Stefanescu Gabriela Dumitrita Stanciu Bogdan-Ionel Tamba
author_facet	Leontina Elena Filipiuc Daniela Carmen Ababei Teodora Alexa-Stratulat Cosmin Vasilica Pricope Veronica Bild Raluca Stefanescu Gabriela Dumitrita Stanciu Bogdan-Ionel Tamba
author_sort	Leontina Elena Filipiuc
title	Major Phytocannabinoids and Their Related Compounds: Should We Only Search for Drugs That Act on Cannabinoid Receptors?
title_short	Major Phytocannabinoids and Their Related Compounds: Should We Only Search for Drugs That Act on Cannabinoid Receptors?
title_full	Major Phytocannabinoids and Their Related Compounds: Should We Only Search for Drugs That Act on Cannabinoid Receptors?
title_fullStr	Major Phytocannabinoids and Their Related Compounds: Should We Only Search for Drugs That Act on Cannabinoid Receptors?
title_full_unstemmed	Major Phytocannabinoids and Their Related Compounds: Should We Only Search for Drugs That Act on Cannabinoid Receptors?
title_sort	major phytocannabinoids and their related compounds: should we only search for drugs that act on cannabinoid receptors?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/97f09f738f7948c4b52915df53435125
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Major Phytocannabinoids and Their Related Compounds: Should We Only Search for Drugs That Act on Cannabinoid Receptors?

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