High plasma concentration of non-esterified polyunsaturated fatty acids is a specific feature of severe COVID-19 pneumonia

Abstract COVID-19 pneumonia has specific features and outcomes that suggests a unique immunopathogenesis. Severe forms of COVID-19 appear to be more frequent in obese patients, but an association with metabolic disorders is not established. Here, we focused on lipoprotein metabolism in patients hosp...

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Autores principales:	Maxime Nguyen, Abderrahmane Bourredjem, Lionel Piroth, Bélaïd Bouhemad, Antoine Jalil, Gaetan Pallot, Naig Le Guern, Charles Thomas, Thomas Pilot, Victoria Bergas, Hélène Choubley, Jean-Pierre Quenot, Pierre-Emmanuel Charles, Laurent Lagrost, Valerie Deckert, Jean-Paul Pais de Barros, Pierre-Grégoire Guinot, David Masson, Christine Binquet, Thomas Gautier, Mathieu Blot, Lymphonie study group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/97f18805af9645668ad7756794ccc87c
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spelling	oai:doaj.org-article:97f18805af9645668ad7756794ccc87c2021-12-02T16:53:00ZHigh plasma concentration of non-esterified polyunsaturated fatty acids is a specific feature of severe COVID-19 pneumonia10.1038/s41598-021-90362-92045-2322https://doaj.org/article/97f18805af9645668ad7756794ccc87c2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90362-9https://doaj.org/toc/2045-2322Abstract COVID-19 pneumonia has specific features and outcomes that suggests a unique immunopathogenesis. Severe forms of COVID-19 appear to be more frequent in obese patients, but an association with metabolic disorders is not established. Here, we focused on lipoprotein metabolism in patients hospitalized for severe pneumonia, depending on COVID-19 status. Thirty-four non-COVID-19 and 27 COVID-19 patients with severe pneumonia were enrolled. Most of them required intensive care. Plasma lipid levels, lipoprotein metabolism, and clinical and biological (including plasma cytokines) features were assessed. Despite similar initial metabolic comorbidities and respiratory severity, COVID-19 patients displayed a lower acute phase response but higher plasmatic concentrations of non-esterified fatty acids (NEFAs). NEFA profiling was characterised by higher level of polyunsaturated NEFAs (mainly linoleic and arachidonic acids) in COVID-19 patients. Multivariable analysis showed that among severe pneumonia, COVID-19-associated pneumonia was associated with higher NEFAs, lower apolipoprotein E and lower high-density lipoprotein cholesterol concentrations, independently of body mass index, sequential organ failure (SOFA) score, and C-reactive protein levels. NEFAs and PUFAs concentrations were negatively correlated with the number of ventilator-free days. Among hospitalized patients with severe pneumonia, COVID-19 is independently associated with higher NEFAs (mainly linoleic and arachidonic acids) and lower apolipoprotein E and HDL concentrations. These features might act as mediators in COVID-19 pathogenesis and emerge as new therapeutic targets. Further investigations are required to define the role of NEFAs in the pathogenesis and the dysregulated immune response associated with COVID-19. Trial registration: NCT04435223.Maxime NguyenAbderrahmane BourredjemLionel PirothBélaïd BouhemadAntoine JalilGaetan PallotNaig Le GuernCharles ThomasThomas PilotVictoria BergasHélène ChoubleyJean-Pierre QuenotPierre-Emmanuel CharlesLaurent LagrostValerie DeckertJean-Paul Pais de BarrosPierre-Grégoire GuinotDavid MassonChristine BinquetThomas GautierMathieu BlotLymphonie study groupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maxime Nguyen Abderrahmane Bourredjem Lionel Piroth Bélaïd Bouhemad Antoine Jalil Gaetan Pallot Naig Le Guern Charles Thomas Thomas Pilot Victoria Bergas Hélène Choubley Jean-Pierre Quenot Pierre-Emmanuel Charles Laurent Lagrost Valerie Deckert Jean-Paul Pais de Barros Pierre-Grégoire Guinot David Masson Christine Binquet Thomas Gautier Mathieu Blot Lymphonie study group High plasma concentration of non-esterified polyunsaturated fatty acids is a specific feature of severe COVID-19 pneumonia
description	Abstract COVID-19 pneumonia has specific features and outcomes that suggests a unique immunopathogenesis. Severe forms of COVID-19 appear to be more frequent in obese patients, but an association with metabolic disorders is not established. Here, we focused on lipoprotein metabolism in patients hospitalized for severe pneumonia, depending on COVID-19 status. Thirty-four non-COVID-19 and 27 COVID-19 patients with severe pneumonia were enrolled. Most of them required intensive care. Plasma lipid levels, lipoprotein metabolism, and clinical and biological (including plasma cytokines) features were assessed. Despite similar initial metabolic comorbidities and respiratory severity, COVID-19 patients displayed a lower acute phase response but higher plasmatic concentrations of non-esterified fatty acids (NEFAs). NEFA profiling was characterised by higher level of polyunsaturated NEFAs (mainly linoleic and arachidonic acids) in COVID-19 patients. Multivariable analysis showed that among severe pneumonia, COVID-19-associated pneumonia was associated with higher NEFAs, lower apolipoprotein E and lower high-density lipoprotein cholesterol concentrations, independently of body mass index, sequential organ failure (SOFA) score, and C-reactive protein levels. NEFAs and PUFAs concentrations were negatively correlated with the number of ventilator-free days. Among hospitalized patients with severe pneumonia, COVID-19 is independently associated with higher NEFAs (mainly linoleic and arachidonic acids) and lower apolipoprotein E and HDL concentrations. These features might act as mediators in COVID-19 pathogenesis and emerge as new therapeutic targets. Further investigations are required to define the role of NEFAs in the pathogenesis and the dysregulated immune response associated with COVID-19. Trial registration: NCT04435223.
format	article
author	Maxime Nguyen Abderrahmane Bourredjem Lionel Piroth Bélaïd Bouhemad Antoine Jalil Gaetan Pallot Naig Le Guern Charles Thomas Thomas Pilot Victoria Bergas Hélène Choubley Jean-Pierre Quenot Pierre-Emmanuel Charles Laurent Lagrost Valerie Deckert Jean-Paul Pais de Barros Pierre-Grégoire Guinot David Masson Christine Binquet Thomas Gautier Mathieu Blot Lymphonie study group
author_facet	Maxime Nguyen Abderrahmane Bourredjem Lionel Piroth Bélaïd Bouhemad Antoine Jalil Gaetan Pallot Naig Le Guern Charles Thomas Thomas Pilot Victoria Bergas Hélène Choubley Jean-Pierre Quenot Pierre-Emmanuel Charles Laurent Lagrost Valerie Deckert Jean-Paul Pais de Barros Pierre-Grégoire Guinot David Masson Christine Binquet Thomas Gautier Mathieu Blot Lymphonie study group
author_sort	Maxime Nguyen
title	High plasma concentration of non-esterified polyunsaturated fatty acids is a specific feature of severe COVID-19 pneumonia
title_short	High plasma concentration of non-esterified polyunsaturated fatty acids is a specific feature of severe COVID-19 pneumonia
title_full	High plasma concentration of non-esterified polyunsaturated fatty acids is a specific feature of severe COVID-19 pneumonia
title_fullStr	High plasma concentration of non-esterified polyunsaturated fatty acids is a specific feature of severe COVID-19 pneumonia
title_full_unstemmed	High plasma concentration of non-esterified polyunsaturated fatty acids is a specific feature of severe COVID-19 pneumonia
title_sort	high plasma concentration of non-esterified polyunsaturated fatty acids is a specific feature of severe covid-19 pneumonia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/97f18805af9645668ad7756794ccc87c
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High plasma concentration of non-esterified polyunsaturated fatty acids is a specific feature of severe COVID-19 pneumonia

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