TELOMERIC PROFILE IN B LYMPHOCYTES FROM THE PATIENTS WITH RHEUMATOID ARTHRITIS

Abstract. Shortening of telomeres represents an important mechanism that limits the proliferative potential of cells. Telomeres are chromatin structures that perform capping and protection of the chromosome ends. In vertebrates, they consist of tandem hexameric repeated sequences (TTAGGG) that are a...

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Autores principales:	E. V. Zinnatova, V. I. Borisov, V. S. Kozhevnikov, A. E. Sizikov, V. A. Kozlov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	telomeres b lymphocytes rheumathoid arthritis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/97f40440dc6548dca0bb02e84710928a
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spelling	oai:doaj.org-article:97f40440dc6548dca0bb02e84710928a2021-11-18T08:03:42ZTELOMERIC PROFILE IN B LYMPHOCYTES FROM THE PATIENTS WITH RHEUMATOID ARTHRITIS1563-06252313-741X10.15789/1563-0625-2011-2-3-151-156https://doaj.org/article/97f40440dc6548dca0bb02e84710928a2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/468https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Shortening of telomeres represents an important mechanism that limits the proliferative potential of cells. Telomeres are chromatin structures that perform capping and protection of the chromosome ends. In vertebrates, they consist of tandem hexameric repeated sequences (TTAGGG) that are associated with various specific proteins. Immune system is extremely susceptible to telomere loss, since cellular proliferation underlies self-renewal of T and B lymphocytes, being also quite necessary for their biological functions. Telomere loss in lymphocytes may contribute to development of immune deficiency, and predispose for autoimmune responses in the elderly. In this study, we analyzed telomere length, the rates of telomere loss, and the variability of telomeres in B cells from rheumatoid arthritis patients, and in healthy donors. Average values of telomere length in healthy donors were found to be, respectively, 1.9 and 2.3 kb longer for B cells, as compared with CD4+ и CD8+Т-lymphocytes. The same tendency was observed in rheumatoid arthritis patients. Estimated rate of telomere loss in B-cells was 20 bp per year in healthy donors, while being slightly faster in rheumatoid arthritis patients. Thus, telomere shortening in B lymphocytes, as well as other senescence mechanisms, may contribute to development of autoimmune disease. (Med. Immunol., 2011, vol. 13, N 2-3, pp 151-156)E. V. ZinnatovaV. I. BorisovV. S. KozhevnikovA. E. SizikovV. A. KozlovSPb RAACIarticletelomeresb lymphocytesrheumathoid arthritisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 2-3, Pp 151-156 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	telomeres b lymphocytes rheumathoid arthritis Immunologic diseases. Allergy RC581-607
spellingShingle	telomeres b lymphocytes rheumathoid arthritis Immunologic diseases. Allergy RC581-607 E. V. Zinnatova V. I. Borisov V. S. Kozhevnikov A. E. Sizikov V. A. Kozlov TELOMERIC PROFILE IN B LYMPHOCYTES FROM THE PATIENTS WITH RHEUMATOID ARTHRITIS
description	Abstract. Shortening of telomeres represents an important mechanism that limits the proliferative potential of cells. Telomeres are chromatin structures that perform capping and protection of the chromosome ends. In vertebrates, they consist of tandem hexameric repeated sequences (TTAGGG) that are associated with various specific proteins. Immune system is extremely susceptible to telomere loss, since cellular proliferation underlies self-renewal of T and B lymphocytes, being also quite necessary for their biological functions. Telomere loss in lymphocytes may contribute to development of immune deficiency, and predispose for autoimmune responses in the elderly. In this study, we analyzed telomere length, the rates of telomere loss, and the variability of telomeres in B cells from rheumatoid arthritis patients, and in healthy donors. Average values of telomere length in healthy donors were found to be, respectively, 1.9 and 2.3 kb longer for B cells, as compared with CD4+ и CD8+Т-lymphocytes. The same tendency was observed in rheumatoid arthritis patients. Estimated rate of telomere loss in B-cells was 20 bp per year in healthy donors, while being slightly faster in rheumatoid arthritis patients. Thus, telomere shortening in B lymphocytes, as well as other senescence mechanisms, may contribute to development of autoimmune disease. (Med. Immunol., 2011, vol. 13, N 2-3, pp 151-156)
format	article
author	E. V. Zinnatova V. I. Borisov V. S. Kozhevnikov A. E. Sizikov V. A. Kozlov
author_facet	E. V. Zinnatova V. I. Borisov V. S. Kozhevnikov A. E. Sizikov V. A. Kozlov
author_sort	E. V. Zinnatova
title	TELOMERIC PROFILE IN B LYMPHOCYTES FROM THE PATIENTS WITH RHEUMATOID ARTHRITIS
title_short	TELOMERIC PROFILE IN B LYMPHOCYTES FROM THE PATIENTS WITH RHEUMATOID ARTHRITIS
title_full	TELOMERIC PROFILE IN B LYMPHOCYTES FROM THE PATIENTS WITH RHEUMATOID ARTHRITIS
title_fullStr	TELOMERIC PROFILE IN B LYMPHOCYTES FROM THE PATIENTS WITH RHEUMATOID ARTHRITIS
title_full_unstemmed	TELOMERIC PROFILE IN B LYMPHOCYTES FROM THE PATIENTS WITH RHEUMATOID ARTHRITIS
title_sort	telomeric profile in b lymphocytes from the patients with rheumatoid arthritis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/97f40440dc6548dca0bb02e84710928a
work_keys_str_mv	AT evzinnatova telomericprofileinblymphocytesfromthepatientswithrheumatoidarthritis AT viborisov telomericprofileinblymphocytesfromthepatientswithrheumatoidarthritis AT vskozhevnikov telomericprofileinblymphocytesfromthepatientswithrheumatoidarthritis AT aesizikov telomericprofileinblymphocytesfromthepatientswithrheumatoidarthritis AT vakozlov telomericprofileinblymphocytesfromthepatientswithrheumatoidarthritis
_version_	1718422494382129152

TELOMERIC PROFILE IN B LYMPHOCYTES FROM THE PATIENTS WITH RHEUMATOID ARTHRITIS

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