Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome

p53 mutants can promote tumorigenesis by affecting fundamental cellular pathways and functions. In this study, the authors demonstrate a novel mutant-p53/HIF1α/miR-30d axis that impacts Golgi structure, trafficking, and secretion of proteins essential for tumor growth and metastasis.

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Autores principales:	Valeria Capaci, Lorenzo Bascetta, Marco Fantuz, Galina V. Beznoussenko, Roberta Sommaggio, Valeria Cancila, Andrea Bisso, Elena Campaner, Alexander A. Mironov, Jacek R. Wiśniewski, Luisa Ulloa Severino, Denis Scaini, Fleur Bossi, Jodi Lees, Noa Alon, Ledia Brunga, David Malkin, Silvano Piazza, Licio Collavin, Antonio Rosato, Silvio Bicciato, Claudio Tripodo, Fiamma Mantovani, Giannino Del Sal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/97f4b2fef7914489a6cce6c57fdc9e48
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spelling	oai:doaj.org-article:97f4b2fef7914489a6cce6c57fdc9e482021-12-02T16:36:37ZMutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome10.1038/s41467-020-17596-52041-1723https://doaj.org/article/97f4b2fef7914489a6cce6c57fdc9e482020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17596-5https://doaj.org/toc/2041-1723p53 mutants can promote tumorigenesis by affecting fundamental cellular pathways and functions. In this study, the authors demonstrate a novel mutant-p53/HIF1α/miR-30d axis that impacts Golgi structure, trafficking, and secretion of proteins essential for tumor growth and metastasis.Valeria CapaciLorenzo BascettaMarco FantuzGalina V. BeznoussenkoRoberta SommaggioValeria CancilaAndrea BissoElena CampanerAlexander A. MironovJacek R. WiśniewskiLuisa Ulloa SeverinoDenis ScainiFleur BossiJodi LeesNoa AlonLedia BrungaDavid MalkinSilvano PiazzaLicio CollavinAntonio RosatoSilvio BicciatoClaudio TripodoFiamma MantovaniGiannino Del SalNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Valeria Capaci Lorenzo Bascetta Marco Fantuz Galina V. Beznoussenko Roberta Sommaggio Valeria Cancila Andrea Bisso Elena Campaner Alexander A. Mironov Jacek R. Wiśniewski Luisa Ulloa Severino Denis Scaini Fleur Bossi Jodi Lees Noa Alon Ledia Brunga David Malkin Silvano Piazza Licio Collavin Antonio Rosato Silvio Bicciato Claudio Tripodo Fiamma Mantovani Giannino Del Sal Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome
description	p53 mutants can promote tumorigenesis by affecting fundamental cellular pathways and functions. In this study, the authors demonstrate a novel mutant-p53/HIF1α/miR-30d axis that impacts Golgi structure, trafficking, and secretion of proteins essential for tumor growth and metastasis.
format	article
author	Valeria Capaci Lorenzo Bascetta Marco Fantuz Galina V. Beznoussenko Roberta Sommaggio Valeria Cancila Andrea Bisso Elena Campaner Alexander A. Mironov Jacek R. Wiśniewski Luisa Ulloa Severino Denis Scaini Fleur Bossi Jodi Lees Noa Alon Ledia Brunga David Malkin Silvano Piazza Licio Collavin Antonio Rosato Silvio Bicciato Claudio Tripodo Fiamma Mantovani Giannino Del Sal
author_facet	Valeria Capaci Lorenzo Bascetta Marco Fantuz Galina V. Beznoussenko Roberta Sommaggio Valeria Cancila Andrea Bisso Elena Campaner Alexander A. Mironov Jacek R. Wiśniewski Luisa Ulloa Severino Denis Scaini Fleur Bossi Jodi Lees Noa Alon Ledia Brunga David Malkin Silvano Piazza Licio Collavin Antonio Rosato Silvio Bicciato Claudio Tripodo Fiamma Mantovani Giannino Del Sal
author_sort	Valeria Capaci
title	Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome
title_short	Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome
title_full	Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome
title_fullStr	Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome
title_full_unstemmed	Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome
title_sort	mutant p53 induces golgi tubulo-vesiculation driving a prometastatic secretome
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/97f4b2fef7914489a6cce6c57fdc9e48
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Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome

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