A Low-Producing Haplotype of Interleukin-6 Disrupting CTCF Binding Is Protective against Severe COVID-19

A Low-Producing Haplotype of Interleukin-6 Disrupting CTCF Binding Is Protective against Severe COVID-19

Overproduction of cytokine interleukin-6 (IL-6) is a hallmark of severe COVID-19 and is believed to play a critical role in exacerbating the excessive inflammatory response. Polymorphisms in IL-6

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Autores principales: Tao Chen, Yu-Xin Lin, Yan Zha, Ying Sun, Jinxiu Tian, Zhiying Yang, Shan-Wen Lin, Fuxun Yu, Zi-Sheng Chen, Bo-Hua Kuang, Jin-Ju Lei, Ying-jie Nie, Yonghao Xu, Dong-Bo Tian, Ying-Zi Li, Bin Yang, Qiang Xu, Li Yang, Nanshan Zhong, Meizhen Zheng, Yimin Li, Jincun Zhao, Xiang-Yan Zhang, Lin Feng
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2021
Materias:
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/97fc514b23474874a78ba95c85b85b89
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spelling oai:doaj.org-article:97fc514b23474874a78ba95c85b85b892021-11-03T21:52:35ZA Low-Producing Haplotype of Interleukin-6 Disrupting CTCF Binding Is Protective against Severe COVID-192150-751110.1128/mBio.01372-21https://doaj.org/article/97fc514b23474874a78ba95c85b85b892021-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01372-21https://doaj.org/toc/2150-7511 Overproduction of cytokine interleukin-6 (IL-6) is a hallmark of severe COVID-19 and is believed to play a critical role in exacerbating the excessive inflammatory response. Polymorphisms in IL-6Tao ChenYu-Xin LinYan ZhaYing SunJinxiu TianZhiying YangShan-Wen LinFuxun YuZi-Sheng ChenBo-Hua KuangJin-Ju LeiYing-jie NieYonghao XuDong-Bo TianYing-Zi LiBin YangQiang XuLi YangNanshan ZhongMeizhen ZhengYimin LiJincun ZhaoXiang-Yan ZhangLin FengAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 5 (2021)
institution DOAJ
collection DOAJ
language EN
topic Microbiology
QR1-502
spellingShingle Microbiology
QR1-502
Tao Chen
Yu-Xin Lin
Yan Zha
Ying Sun
Jinxiu Tian
Zhiying Yang
Shan-Wen Lin
Fuxun Yu
Zi-Sheng Chen
Bo-Hua Kuang
Jin-Ju Lei
Ying-jie Nie
Yonghao Xu
Dong-Bo Tian
Ying-Zi Li
Bin Yang
Qiang Xu
Li Yang
Nanshan Zhong
Meizhen Zheng
Yimin Li
Jincun Zhao
Xiang-Yan Zhang
Lin Feng
A Low-Producing Haplotype of Interleukin-6 Disrupting CTCF Binding Is Protective against Severe COVID-19
description Overproduction of cytokine interleukin-6 (IL-6) is a hallmark of severe COVID-19 and is believed to play a critical role in exacerbating the excessive inflammatory response. Polymorphisms in IL-6
format article
author Tao Chen
Yu-Xin Lin
Yan Zha
Ying Sun
Jinxiu Tian
Zhiying Yang
Shan-Wen Lin
Fuxun Yu
Zi-Sheng Chen
Bo-Hua Kuang
Jin-Ju Lei
Ying-jie Nie
Yonghao Xu
Dong-Bo Tian
Ying-Zi Li
Bin Yang
Qiang Xu
Li Yang
Nanshan Zhong
Meizhen Zheng
Yimin Li
Jincun Zhao
Xiang-Yan Zhang
Lin Feng
author_facet Tao Chen
Yu-Xin Lin
Yan Zha
Ying Sun
Jinxiu Tian
Zhiying Yang
Shan-Wen Lin
Fuxun Yu
Zi-Sheng Chen
Bo-Hua Kuang
Jin-Ju Lei
Ying-jie Nie
Yonghao Xu
Dong-Bo Tian
Ying-Zi Li
Bin Yang
Qiang Xu
Li Yang
Nanshan Zhong
Meizhen Zheng
Yimin Li
Jincun Zhao
Xiang-Yan Zhang
Lin Feng
author_sort Tao Chen
title A Low-Producing Haplotype of Interleukin-6 Disrupting CTCF Binding Is Protective against Severe COVID-19
title_short A Low-Producing Haplotype of Interleukin-6 Disrupting CTCF Binding Is Protective against Severe COVID-19
title_full A Low-Producing Haplotype of Interleukin-6 Disrupting CTCF Binding Is Protective against Severe COVID-19
title_fullStr A Low-Producing Haplotype of Interleukin-6 Disrupting CTCF Binding Is Protective against Severe COVID-19
title_full_unstemmed A Low-Producing Haplotype of Interleukin-6 Disrupting CTCF Binding Is Protective against Severe COVID-19
title_sort low-producing haplotype of interleukin-6 disrupting ctcf binding is protective against severe covid-19
publisher American Society for Microbiology
publishDate 2021
url https://doaj.org/article/97fc514b23474874a78ba95c85b85b89
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