Tau exacerbates excitotoxic brain damage in an animal model of stroke

Excitotoxicity contributes to neuronal injury following stroke. Here the authors show that tau promotes excitotoxicity by a post-synaptic mechanism, involving site-specific control of ERK activation, in a mouse model of stroke.

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Autores principales:	Mian Bi, Amadeus Gladbach, Janet van Eersel, Arne Ittner, Magdalena Przybyla, Annika van Hummel, Sook Wern Chua, Julia van der Hoven, Wei S. Lee, Julius Müller, Jasneet Parmar, Georg von Jonquieres, Holly Stefen, Ernesto Guccione, Thomas Fath, Gary D. Housley, Matthias Klugmann, Yazi D. Ke, Lars M. Ittner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/97fd15d6e4f1429dae0533cf6a3311e1
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spelling	oai:doaj.org-article:97fd15d6e4f1429dae0533cf6a3311e12021-12-02T15:38:31ZTau exacerbates excitotoxic brain damage in an animal model of stroke10.1038/s41467-017-00618-02041-1723https://doaj.org/article/97fd15d6e4f1429dae0533cf6a3311e12017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00618-0https://doaj.org/toc/2041-1723Excitotoxicity contributes to neuronal injury following stroke. Here the authors show that tau promotes excitotoxicity by a post-synaptic mechanism, involving site-specific control of ERK activation, in a mouse model of stroke.Mian BiAmadeus GladbachJanet van EerselArne IttnerMagdalena PrzybylaAnnika van HummelSook Wern ChuaJulia van der HovenWei S. LeeJulius MüllerJasneet ParmarGeorg von JonquieresHolly StefenErnesto GuccioneThomas FathGary D. HousleyMatthias KlugmannYazi D. KeLars M. IttnerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mian Bi Amadeus Gladbach Janet van Eersel Arne Ittner Magdalena Przybyla Annika van Hummel Sook Wern Chua Julia van der Hoven Wei S. Lee Julius Müller Jasneet Parmar Georg von Jonquieres Holly Stefen Ernesto Guccione Thomas Fath Gary D. Housley Matthias Klugmann Yazi D. Ke Lars M. Ittner Tau exacerbates excitotoxic brain damage in an animal model of stroke
description	Excitotoxicity contributes to neuronal injury following stroke. Here the authors show that tau promotes excitotoxicity by a post-synaptic mechanism, involving site-specific control of ERK activation, in a mouse model of stroke.
format	article
author	Mian Bi Amadeus Gladbach Janet van Eersel Arne Ittner Magdalena Przybyla Annika van Hummel Sook Wern Chua Julia van der Hoven Wei S. Lee Julius Müller Jasneet Parmar Georg von Jonquieres Holly Stefen Ernesto Guccione Thomas Fath Gary D. Housley Matthias Klugmann Yazi D. Ke Lars M. Ittner
author_facet	Mian Bi Amadeus Gladbach Janet van Eersel Arne Ittner Magdalena Przybyla Annika van Hummel Sook Wern Chua Julia van der Hoven Wei S. Lee Julius Müller Jasneet Parmar Georg von Jonquieres Holly Stefen Ernesto Guccione Thomas Fath Gary D. Housley Matthias Klugmann Yazi D. Ke Lars M. Ittner
author_sort	Mian Bi
title	Tau exacerbates excitotoxic brain damage in an animal model of stroke
title_short	Tau exacerbates excitotoxic brain damage in an animal model of stroke
title_full	Tau exacerbates excitotoxic brain damage in an animal model of stroke
title_fullStr	Tau exacerbates excitotoxic brain damage in an animal model of stroke
title_full_unstemmed	Tau exacerbates excitotoxic brain damage in an animal model of stroke
title_sort	tau exacerbates excitotoxic brain damage in an animal model of stroke
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/97fd15d6e4f1429dae0533cf6a3311e1
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Tau exacerbates excitotoxic brain damage in an animal model of stroke

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