Actin cytoskeleton deregulation confers midostaurin resistance in FLT3-mutant acute myeloid leukemia

Garitano-Trojaola et al. used a combination of human acute myeloid leukemia (AML) cell lines and primary samples to show that RAC1-dependent actin cytoskeleton remodeling through BCL2 family plays a key role in resistance to the FLT3 inhibitor, Midostaurin in AML. They showed that by targeting RAC1...

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Autores principales:	Andoni Garitano-Trojaola, Ana Sancho, Ralph Götz, Patrick Eiring, Susanne Walz, Hardikkumar Jetani, Jesus Gil-Pulido, Matteo Claudio Da Via, Eva Teufel, Nadine Rhodes, Larissa Haertle, Estibaliz Arellano-Viera, Raoul Tibes, Andreas Rosenwald, Leo Rasche, Michael Hudecek, Markus Sauer, Jürgen Groll, Hermann Einsele, Sabrina Kraus, Martin K. Kortüm
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/97fe6acc0451456bbe96d2d7eec2c3f6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:97fe6acc0451456bbe96d2d7eec2c3f62021-12-02T17:44:54ZActin cytoskeleton deregulation confers midostaurin resistance in FLT3-mutant acute myeloid leukemia10.1038/s42003-021-02215-w2399-3642https://doaj.org/article/97fe6acc0451456bbe96d2d7eec2c3f62021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02215-whttps://doaj.org/toc/2399-3642Garitano-Trojaola et al. used a combination of human acute myeloid leukemia (AML) cell lines and primary samples to show that RAC1-dependent actin cytoskeleton remodeling through BCL2 family plays a key role in resistance to the FLT3 inhibitor, Midostaurin in AML. They showed that by targeting RAC1 and BCL2, Midostaurin resistance was diminished, which potentially paves the way for an innovate treatment approach for FLT3 mutant AML.Andoni Garitano-TrojaolaAna SanchoRalph GötzPatrick EiringSusanne WalzHardikkumar JetaniJesus Gil-PulidoMatteo Claudio Da ViaEva TeufelNadine RhodesLarissa HaertleEstibaliz Arellano-VieraRaoul TibesAndreas RosenwaldLeo RascheMichael HudecekMarkus SauerJürgen GrollHermann EinseleSabrina KrausMartin K. KortümNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Andoni Garitano-Trojaola Ana Sancho Ralph Götz Patrick Eiring Susanne Walz Hardikkumar Jetani Jesus Gil-Pulido Matteo Claudio Da Via Eva Teufel Nadine Rhodes Larissa Haertle Estibaliz Arellano-Viera Raoul Tibes Andreas Rosenwald Leo Rasche Michael Hudecek Markus Sauer Jürgen Groll Hermann Einsele Sabrina Kraus Martin K. Kortüm Actin cytoskeleton deregulation confers midostaurin resistance in FLT3-mutant acute myeloid leukemia
description	Garitano-Trojaola et al. used a combination of human acute myeloid leukemia (AML) cell lines and primary samples to show that RAC1-dependent actin cytoskeleton remodeling through BCL2 family plays a key role in resistance to the FLT3 inhibitor, Midostaurin in AML. They showed that by targeting RAC1 and BCL2, Midostaurin resistance was diminished, which potentially paves the way for an innovate treatment approach for FLT3 mutant AML.
format	article
author	Andoni Garitano-Trojaola Ana Sancho Ralph Götz Patrick Eiring Susanne Walz Hardikkumar Jetani Jesus Gil-Pulido Matteo Claudio Da Via Eva Teufel Nadine Rhodes Larissa Haertle Estibaliz Arellano-Viera Raoul Tibes Andreas Rosenwald Leo Rasche Michael Hudecek Markus Sauer Jürgen Groll Hermann Einsele Sabrina Kraus Martin K. Kortüm
author_facet	Andoni Garitano-Trojaola Ana Sancho Ralph Götz Patrick Eiring Susanne Walz Hardikkumar Jetani Jesus Gil-Pulido Matteo Claudio Da Via Eva Teufel Nadine Rhodes Larissa Haertle Estibaliz Arellano-Viera Raoul Tibes Andreas Rosenwald Leo Rasche Michael Hudecek Markus Sauer Jürgen Groll Hermann Einsele Sabrina Kraus Martin K. Kortüm
author_sort	Andoni Garitano-Trojaola
title	Actin cytoskeleton deregulation confers midostaurin resistance in FLT3-mutant acute myeloid leukemia
title_short	Actin cytoskeleton deregulation confers midostaurin resistance in FLT3-mutant acute myeloid leukemia
title_full	Actin cytoskeleton deregulation confers midostaurin resistance in FLT3-mutant acute myeloid leukemia
title_fullStr	Actin cytoskeleton deregulation confers midostaurin resistance in FLT3-mutant acute myeloid leukemia
title_full_unstemmed	Actin cytoskeleton deregulation confers midostaurin resistance in FLT3-mutant acute myeloid leukemia
title_sort	actin cytoskeleton deregulation confers midostaurin resistance in flt3-mutant acute myeloid leukemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/97fe6acc0451456bbe96d2d7eec2c3f6
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Actin cytoskeleton deregulation confers midostaurin resistance in FLT3-mutant acute myeloid leukemia

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