Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers

Current widely used viral and electroporation methods for creating therapeutic cell-based products are complex and expensive. Here, the authors develop targeted mRNA nanocarriers that can transiently program gene expression by simply mixing them with cells, to improve their therapeutic potential.

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Detalles Bibliográficos
Autores principales:	H. F. Moffett, M. E. Coon, S. Radtke, S. B. Stephan, L. McKnight, A. Lambert, B. L. Stoddard, H. P. Kiem, M. T. Stephan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/980299c002f4470893064c45e6cc2b18
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spelling	oai:doaj.org-article:980299c002f4470893064c45e6cc2b182021-12-02T14:42:03ZHit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers10.1038/s41467-017-00505-82041-1723https://doaj.org/article/980299c002f4470893064c45e6cc2b182017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00505-8https://doaj.org/toc/2041-1723Current widely used viral and electroporation methods for creating therapeutic cell-based products are complex and expensive. Here, the authors develop targeted mRNA nanocarriers that can transiently program gene expression by simply mixing them with cells, to improve their therapeutic potential.H. F. MoffettM. E. CoonS. RadtkeS. B. StephanL. McKnightA. LambertB. L. StoddardH. P. KiemM. T. StephanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q H. F. Moffett M. E. Coon S. Radtke S. B. Stephan L. McKnight A. Lambert B. L. Stoddard H. P. Kiem M. T. Stephan Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers
description	Current widely used viral and electroporation methods for creating therapeutic cell-based products are complex and expensive. Here, the authors develop targeted mRNA nanocarriers that can transiently program gene expression by simply mixing them with cells, to improve their therapeutic potential.
format	article
author	H. F. Moffett M. E. Coon S. Radtke S. B. Stephan L. McKnight A. Lambert B. L. Stoddard H. P. Kiem M. T. Stephan
author_facet	H. F. Moffett M. E. Coon S. Radtke S. B. Stephan L. McKnight A. Lambert B. L. Stoddard H. P. Kiem M. T. Stephan
author_sort	H. F. Moffett
title	Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers
title_short	Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers
title_full	Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers
title_fullStr	Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers
title_full_unstemmed	Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers
title_sort	hit-and-run programming of therapeutic cytoreagents using mrna nanocarriers
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/980299c002f4470893064c45e6cc2b18
work_keys_str_mv	AT hfmoffett hitandrunprogrammingoftherapeuticcytoreagentsusingmrnananocarriers AT mecoon hitandrunprogrammingoftherapeuticcytoreagentsusingmrnananocarriers AT sradtke hitandrunprogrammingoftherapeuticcytoreagentsusingmrnananocarriers AT sbstephan hitandrunprogrammingoftherapeuticcytoreagentsusingmrnananocarriers AT lmcknight hitandrunprogrammingoftherapeuticcytoreagentsusingmrnananocarriers AT alambert hitandrunprogrammingoftherapeuticcytoreagentsusingmrnananocarriers AT blstoddard hitandrunprogrammingoftherapeuticcytoreagentsusingmrnananocarriers AT hpkiem hitandrunprogrammingoftherapeuticcytoreagentsusingmrnananocarriers AT mtstephan hitandrunprogrammingoftherapeuticcytoreagentsusingmrnananocarriers
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Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers

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