De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands

Aberrant gain of DNA methylation at CpG islands is frequently observed in colorectal tumours. Here the authors use ectopically integrated CpG islands in colorectal cancer cells and find that aberrantly methylated CpG islands are subject to low levels of de novo DNA methylation, and that instead de n...

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Autores principales:	Roza H. Ali Masalmeh, Francesca Taglini, Cristina Rubio-Ramon, Kamila I. Musialik, Jonathan Higham, Hazel Davidson-Smith, Ioannis Kafetzopoulos, Kamila P. Pawlicka, Hannah M. Finan, Richard Clark, Jimi Wills, Andrew J. Finch, Lee Murphy, Duncan Sproul
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9803ec9958634a5e94312be4787e0b29
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spelling	oai:doaj.org-article:9803ec9958634a5e94312be4787e0b292021-12-02T10:47:58ZDe novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands10.1038/s41467-020-20716-w2041-1723https://doaj.org/article/9803ec9958634a5e94312be4787e0b292021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20716-whttps://doaj.org/toc/2041-1723Aberrant gain of DNA methylation at CpG islands is frequently observed in colorectal tumours. Here the authors use ectopically integrated CpG islands in colorectal cancer cells and find that aberrantly methylated CpG islands are subject to low levels of de novo DNA methylation, and that instead de novo DNA methylation activity is targeted primarily to CpG islands marked by the histone modification H3K36me3.Roza H. Ali MasalmehFrancesca TagliniCristina Rubio-RamonKamila I. MusialikJonathan HighamHazel Davidson-SmithIoannis KafetzopoulosKamila P. PawlickaHannah M. FinanRichard ClarkJimi WillsAndrew J. FinchLee MurphyDuncan SproulNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Roza H. Ali Masalmeh Francesca Taglini Cristina Rubio-Ramon Kamila I. Musialik Jonathan Higham Hazel Davidson-Smith Ioannis Kafetzopoulos Kamila P. Pawlicka Hannah M. Finan Richard Clark Jimi Wills Andrew J. Finch Lee Murphy Duncan Sproul De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands
description	Aberrant gain of DNA methylation at CpG islands is frequently observed in colorectal tumours. Here the authors use ectopically integrated CpG islands in colorectal cancer cells and find that aberrantly methylated CpG islands are subject to low levels of de novo DNA methylation, and that instead de novo DNA methylation activity is targeted primarily to CpG islands marked by the histone modification H3K36me3.
format	article
author	Roza H. Ali Masalmeh Francesca Taglini Cristina Rubio-Ramon Kamila I. Musialik Jonathan Higham Hazel Davidson-Smith Ioannis Kafetzopoulos Kamila P. Pawlicka Hannah M. Finan Richard Clark Jimi Wills Andrew J. Finch Lee Murphy Duncan Sproul
author_facet	Roza H. Ali Masalmeh Francesca Taglini Cristina Rubio-Ramon Kamila I. Musialik Jonathan Higham Hazel Davidson-Smith Ioannis Kafetzopoulos Kamila P. Pawlicka Hannah M. Finan Richard Clark Jimi Wills Andrew J. Finch Lee Murphy Duncan Sproul
author_sort	Roza H. Ali Masalmeh
title	De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands
title_short	De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands
title_full	De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands
title_fullStr	De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands
title_full_unstemmed	De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands
title_sort	de novo dna methyltransferase activity in colorectal cancer is directed towards h3k36me3 marked cpg islands
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9803ec9958634a5e94312be4787e0b29
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De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands

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