Possible burden of hyperuricaemia on mortality in a community-based population: a large-scale cohort study
Abstract Hyperuricaemia is a risk for premature death. This study evaluated the burden of hyperuricaemia (serum urate > 7 mg/dL) for all-cause and cardiovascular mortality in 515,979 health checkup participants using an index of population attributable fraction (PAF). Prevalence of hyperuricaemia...
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Nature Portfolio
2021
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oai:doaj.org-article:98064dac817c4217897d0f2ed844a57d2021-12-02T13:41:00ZPossible burden of hyperuricaemia on mortality in a community-based population: a large-scale cohort study10.1038/s41598-021-88631-82045-2322https://doaj.org/article/98064dac817c4217897d0f2ed844a57d2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88631-8https://doaj.org/toc/2045-2322Abstract Hyperuricaemia is a risk for premature death. This study evaluated the burden of hyperuricaemia (serum urate > 7 mg/dL) for all-cause and cardiovascular mortality in 515,979 health checkup participants using an index of population attributable fraction (PAF). Prevalence of hyperuricaemia at baseline was 10.8% in total subjects (21.8% for men and 2.5% for women). During 9-year follow-up, 5952 deaths were noted, including 1164 cardiovascular deaths. In the Cox proportional hazard analysis adjusted for confounding factors, hyperuricaemia was independently associated with all-cause and cardiovascular mortality (adjusted hazard ratios [95% confidence interval]; 1.36 [1.25–1.49] and 1.69 [1.41–2.01], respectively). Adjusted PAFs of hyperuricaemia for all-cause and cardiovascular deaths were 2.9% and 4.4% (approximately 1 in 34 all-cause deaths and 1 in 23 cardiovascular deaths), respectively. In the subgroup analysis, the association between hyperuricaemia and death was stronger in men, smokers, and subjects with renal insufficiency. Adjusted PAFs for all-cause and cardiovascular deaths were 5.3% and 8.1% in men; 5.8% and 7.5% in smokers; and 5.5% and 7.3% in subjects with renal insufficiency. These results disclosed that a substantial number of all-cause and cardiovascular deaths were statistically relevant to hyperuricaemia in the community-based population, especially men, smokers, and subjects with renal insufficiency.Yoichiro OtakiTsuneo KontaKazunobu IchikawaShouichi FujimotoKunitoshi IsekiToshiki MoriyamaKunihiro YamagataKazuhiko TsuruyaIchiei NaritaMasahide KondoYugo ShibagakiMasato KasaharaKoichi AsahiTsuyoshi WatanabeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021) |
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Medicine R Science Q Yoichiro Otaki Tsuneo Konta Kazunobu Ichikawa Shouichi Fujimoto Kunitoshi Iseki Toshiki Moriyama Kunihiro Yamagata Kazuhiko Tsuruya Ichiei Narita Masahide Kondo Yugo Shibagaki Masato Kasahara Koichi Asahi Tsuyoshi Watanabe Possible burden of hyperuricaemia on mortality in a community-based population: a large-scale cohort study |
| description |
Abstract Hyperuricaemia is a risk for premature death. This study evaluated the burden of hyperuricaemia (serum urate > 7 mg/dL) for all-cause and cardiovascular mortality in 515,979 health checkup participants using an index of population attributable fraction (PAF). Prevalence of hyperuricaemia at baseline was 10.8% in total subjects (21.8% for men and 2.5% for women). During 9-year follow-up, 5952 deaths were noted, including 1164 cardiovascular deaths. In the Cox proportional hazard analysis adjusted for confounding factors, hyperuricaemia was independently associated with all-cause and cardiovascular mortality (adjusted hazard ratios [95% confidence interval]; 1.36 [1.25–1.49] and 1.69 [1.41–2.01], respectively). Adjusted PAFs of hyperuricaemia for all-cause and cardiovascular deaths were 2.9% and 4.4% (approximately 1 in 34 all-cause deaths and 1 in 23 cardiovascular deaths), respectively. In the subgroup analysis, the association between hyperuricaemia and death was stronger in men, smokers, and subjects with renal insufficiency. Adjusted PAFs for all-cause and cardiovascular deaths were 5.3% and 8.1% in men; 5.8% and 7.5% in smokers; and 5.5% and 7.3% in subjects with renal insufficiency. These results disclosed that a substantial number of all-cause and cardiovascular deaths were statistically relevant to hyperuricaemia in the community-based population, especially men, smokers, and subjects with renal insufficiency. |
| format |
article |
| author |
Yoichiro Otaki Tsuneo Konta Kazunobu Ichikawa Shouichi Fujimoto Kunitoshi Iseki Toshiki Moriyama Kunihiro Yamagata Kazuhiko Tsuruya Ichiei Narita Masahide Kondo Yugo Shibagaki Masato Kasahara Koichi Asahi Tsuyoshi Watanabe |
| author_facet |
Yoichiro Otaki Tsuneo Konta Kazunobu Ichikawa Shouichi Fujimoto Kunitoshi Iseki Toshiki Moriyama Kunihiro Yamagata Kazuhiko Tsuruya Ichiei Narita Masahide Kondo Yugo Shibagaki Masato Kasahara Koichi Asahi Tsuyoshi Watanabe |
| author_sort |
Yoichiro Otaki |
| title |
Possible burden of hyperuricaemia on mortality in a community-based population: a large-scale cohort study |
| title_short |
Possible burden of hyperuricaemia on mortality in a community-based population: a large-scale cohort study |
| title_full |
Possible burden of hyperuricaemia on mortality in a community-based population: a large-scale cohort study |
| title_fullStr |
Possible burden of hyperuricaemia on mortality in a community-based population: a large-scale cohort study |
| title_full_unstemmed |
Possible burden of hyperuricaemia on mortality in a community-based population: a large-scale cohort study |
| title_sort |
possible burden of hyperuricaemia on mortality in a community-based population: a large-scale cohort study |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/98064dac817c4217897d0f2ed844a57d |
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