Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice
Spinal pain is a major clinical problem. Here the authors show that osteoclasts create porous area of endplates of the vertebrae and sensory innervation of porous endplates by Netrin-1 release from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice.
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Nature Portfolio
2019
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oai:doaj.org-article:98071ec5c6bf43b7abff3310ff804c582021-12-02T14:38:42ZSensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice10.1038/s41467-019-13476-92041-1723https://doaj.org/article/98071ec5c6bf43b7abff3310ff804c582019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13476-9https://doaj.org/toc/2041-1723Spinal pain is a major clinical problem. Here the authors show that osteoclasts create porous area of endplates of the vertebrae and sensory innervation of porous endplates by Netrin-1 release from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice.Shuangfei NiZemin LingXiao WangYong CaoTianding WuRuoxian DengJanet L. CraneRichard SkolaskyShadpour DemehriGehua ZhenAmit JainPanfeng WuDayu PanBo HuXiao LyuYusheng LiHao ChenHuabin QiYun GuanXinzhong DongMei WanXuenong ZouHongbin LuJianzhong HuXu CaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Shuangfei Ni Zemin Ling Xiao Wang Yong Cao Tianding Wu Ruoxian Deng Janet L. Crane Richard Skolasky Shadpour Demehri Gehua Zhen Amit Jain Panfeng Wu Dayu Pan Bo Hu Xiao Lyu Yusheng Li Hao Chen Huabin Qi Yun Guan Xinzhong Dong Mei Wan Xuenong Zou Hongbin Lu Jianzhong Hu Xu Cao Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice |
| description |
Spinal pain is a major clinical problem. Here the authors show that osteoclasts create porous area of endplates of the vertebrae and sensory innervation of porous endplates by Netrin-1 release from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice. |
| format |
article |
| author |
Shuangfei Ni Zemin Ling Xiao Wang Yong Cao Tianding Wu Ruoxian Deng Janet L. Crane Richard Skolasky Shadpour Demehri Gehua Zhen Amit Jain Panfeng Wu Dayu Pan Bo Hu Xiao Lyu Yusheng Li Hao Chen Huabin Qi Yun Guan Xinzhong Dong Mei Wan Xuenong Zou Hongbin Lu Jianzhong Hu Xu Cao |
| author_facet |
Shuangfei Ni Zemin Ling Xiao Wang Yong Cao Tianding Wu Ruoxian Deng Janet L. Crane Richard Skolasky Shadpour Demehri Gehua Zhen Amit Jain Panfeng Wu Dayu Pan Bo Hu Xiao Lyu Yusheng Li Hao Chen Huabin Qi Yun Guan Xinzhong Dong Mei Wan Xuenong Zou Hongbin Lu Jianzhong Hu Xu Cao |
| author_sort |
Shuangfei Ni |
| title |
Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice |
| title_short |
Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice |
| title_full |
Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice |
| title_fullStr |
Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice |
| title_full_unstemmed |
Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice |
| title_sort |
sensory innervation in porous endplates by netrin-1 from osteoclasts mediates pge2-induced spinal hypersensitivity in mice |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/98071ec5c6bf43b7abff3310ff804c58 |
| work_keys_str_mv |
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