p53 downregulates the Fanconi anaemia DNA repair pathway

P53 is regarded as the guardian of the genome, however it is known that mice with increased p53 activity display characteristics of dyskeratosis congenita. Here the authors show that increased p53 activity leads to the repression of telomere maintenance and DNA repair genes.

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Autores principales:	Sara Jaber, Eléonore Toufektchan, Vincent Lejour, Boris Bardot, Franck Toledo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/980839b6474840f591fdd5fbe70b2a32
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spelling	oai:doaj.org-article:980839b6474840f591fdd5fbe70b2a322021-12-02T17:31:34Zp53 downregulates the Fanconi anaemia DNA repair pathway10.1038/ncomms110912041-1723https://doaj.org/article/980839b6474840f591fdd5fbe70b2a322016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11091https://doaj.org/toc/2041-1723P53 is regarded as the guardian of the genome, however it is known that mice with increased p53 activity display characteristics of dyskeratosis congenita. Here the authors show that increased p53 activity leads to the repression of telomere maintenance and DNA repair genes.Sara JaberEléonore ToufektchanVincent LejourBoris BardotFranck ToledoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sara Jaber Eléonore Toufektchan Vincent Lejour Boris Bardot Franck Toledo p53 downregulates the Fanconi anaemia DNA repair pathway
description	P53 is regarded as the guardian of the genome, however it is known that mice with increased p53 activity display characteristics of dyskeratosis congenita. Here the authors show that increased p53 activity leads to the repression of telomere maintenance and DNA repair genes.
format	article
author	Sara Jaber Eléonore Toufektchan Vincent Lejour Boris Bardot Franck Toledo
author_facet	Sara Jaber Eléonore Toufektchan Vincent Lejour Boris Bardot Franck Toledo
author_sort	Sara Jaber
title	p53 downregulates the Fanconi anaemia DNA repair pathway
title_short	p53 downregulates the Fanconi anaemia DNA repair pathway
title_full	p53 downregulates the Fanconi anaemia DNA repair pathway
title_fullStr	p53 downregulates the Fanconi anaemia DNA repair pathway
title_full_unstemmed	p53 downregulates the Fanconi anaemia DNA repair pathway
title_sort	p53 downregulates the fanconi anaemia dna repair pathway
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/980839b6474840f591fdd5fbe70b2a32
work_keys_str_mv	AT sarajaber p53downregulatesthefanconianaemiadnarepairpathway AT eleonoretoufektchan p53downregulatesthefanconianaemiadnarepairpathway AT vincentlejour p53downregulatesthefanconianaemiadnarepairpathway AT borisbardot p53downregulatesthefanconianaemiadnarepairpathway AT francktoledo p53downregulatesthefanconianaemiadnarepairpathway
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p53 downregulates the Fanconi anaemia DNA repair pathway

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