D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Virus Titer via Enhanced Furin-Mediated Spike Cleavage

D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Virus Titer via Enhanced Furin-Mediated Spike Cleavage

ABSTRACT Since the D614G substitution in the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged, the variant strain has undergone a rapid expansion to become the most abundant strain worldwide. Therefore, this substitution may provide an advantage for viral spr...

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Autores principales: Ya-Wen Cheng, Tai-Ling Chao, Chiao-Ling Li, Sheng-Han Wang, Han-Chieh Kao, Ya-Min Tsai, Hurng-Yi Wang, Chi-Ling Hsieh, You-Yu Lin, Pei-Jer Chen, Sui-Yuan Chang, Shiou-Hwei Yeh
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2021
Materias:
furin
SARS-CoV-2
spike
syncytium
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/9809a8e9343e41a8ad2817edd2a2befd
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